# Biossance Squalane + Lactic Acid Resurfacing Night Serum for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Biossance](https://lovi.care/skincare/brands/biossance)
Category: [Exfoliants](https://lovi.care/skincare/best/exfoliators)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other products fit it better.

## Why this fit

- Offers moderate exfoliation for your oily skin due to lactic acid, which helps smooth texture and balance sebum production, complemented by squalane for hydration without exacerbating oiliness.
- While the formulation provides general skincare benefits, its primary focus is not directly addressing your acne, blemishes, and breakouts.
- The product is safe for your oily skin, as it lacks harsh ingredients and includes soothing lavender oil to minimize irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Squalane, Lactic Acid, Glycerin, Lavender Oil, Acacia Senegal Gum

## What the research says

- Topical application of a vitamin C-squalene bioconjugate significantly increased epidermal thickness, type III collagen production, and glycosaminoglycans production in human skin explants compared to free vitamin C and vitamin C-palmitate. ([Scientific Reports, 2020](https://pubmed.ncbi.nlm.nih.gov/33037252/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Application of squalene/phosphotungstate calcium nanowires (Sql/PWC) oleogel on UVB-irradiated skin decreased epidermal thickness, increased dermal thickness, and promoted the expression of elastin, collagen, and skin barrier markers through antioxidant and anti-inflammatory activities. ([Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Polysaccharide-based O/W emulsions incorporated with lavender essential oil applied to cellulosic support are non-irritating, provide softness and moisturizing effects, and are safe for topical patch applications. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34547316/))
- Gellan gum hydrogel films co-encapsulating ofloxacin with tea tree or lavender oil achieved 98% wound contraction and completely healed epidermis in rats after ten days of treatment compared to baseline. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33130262/))
- Topical application of lavender oil significantly promoted wound contraction, collagen synthesis, and fibroblast differentiation with up-regulation of TGF-beta in a rat model compared to control. ([BMC Complementary and Alternative Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/27229681/))
- Acacia gum and carbopol hydrogel wound dressings containing gentamicin showed faster wound healing, well-developed fibroblasts, and blood capillaries compared to open wounds in swiss albino mice. ([International Journal of Pharmaceutics, 2013](https://pubmed.ncbi.nlm.nih.gov/24075861/))
- Barley beta-glucan films formulated with sorbitol and acacia gum demonstrated suitable mechanical properties and stimulated in vitro keratinocytes growth. ([International Journal of Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/37028573/))
- Gum arabic and beta-cyclodextrin microencapsulated peony seed oil emulsion protected against ultraviolet radiation by inhibiting reactive oxygen species generation, increasing cell viability from 54.75% to 92.69% in UVB-damaged HaCaT cells, and repairing 95.56% of UVB-damaged skin within 7 days in animal experiments through regulation of the NF-kappaB signaling pathway. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41734836/))

## Why other products fit oily acne-prone skin better

- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on a very large amount of data, this serum is highly effective at smoothing rough texture and brightening dull skin, often overnight, without causing dryness. Most users, including those with sensitive skin, find it gentle and hydrating. A moderate number of users dislike the herbal scent and find the product expensive, while a low number report experiencing irritation or breakouts.

- Liked: Smoothes skin texture (mostly mentioned)
- Liked: Brightens complexion (often mentioned)
- Liked: Gentle and hydrating (often mentioned)
- Liked: Fades dark spots (sometimes noted)
- Disliked: Herbal scent disliked (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Causes irritation (rarely noted)

## How to apply

- Use this exfoliant as part of your PM routine once a week to start, increasing frequency only if your skin tolerates it well.
- Apply the exfoliant after cleansing and toning, but before your final moisturizer step.
- Gently press 2-3 drops of the exfoliant into your skin and let it absorb for a minute.
- Apply the product directly onto clean, dry skin for the best results against breakouts.
- Avoid the sensitive eye area and always use a daily SPF since exfoliating makes skin more sensitive to the sun.
- Video: https://storage.pora.ai/028e5e793422a3b665c02ff502cf5a68.mp4

## Questions and answers

### How well does Biossance Squalane + Lactic Acid Resurfacing Night Serum work for oily acne-prone skin?

Biossance Squalane + Lactic Acid Resurfacing Night Serum works moderately well for your oily acne-prone skin, smoothing texture and balancing oil while keeping irritation low with lavender oil, though it does not focus directly on breakouts. An exfoliant treatment for this skin needs ingredients like niacinamide, propolis, or Vitamin C to target acne and blemishes while controlling excess oil and keeping skin hydrated.
Sources: [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

This serum works for your oily skin because lactic acid helps smooth texture and balance oil, while squalane provides hydration without making you greasy, and lavender oil soothes irritation. To be a better fit for oily acne-prone skin, this type of product needs ingredients like niacinamide, propolis, or Vitamin C to target breakouts and blemishes directly while keeping the skin calm and comfortable.
Sources: [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/)

### What does Squalane do for oily acne-prone skin?

Squalane may help keep oily skin soft and smooth, but oxidized squalene can trigger inflammation in acne-prone skin. Because of this, oily acne-prone skin needs lightweight, non-greasy ingredients that balance moisture without clogging pores.
Sources: [The Journal of Investigative Dermatology, 2006](https://pubmed.ncbi.nlm.nih.gov/16778793/)

### What does Lactic Acid do for oily acne-prone skin?

Lactic acid helps oily acne-prone skin by gently clearing pores and reducing breakouts, which supports a smoother and clearer face. Using appropriate cosmetic acids helps calm red bumps and works well alongside acne treatments.
Sources: [Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, und Verwandte Gebiete, 2010](https://pubmed.ncbi.nlm.nih.gov/20107752/), [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37228782/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in your evening routine as a treatment step, used once a week to start. It helps smooth texture and balance oil for your skin, though an average fit for acne-prone skin means it also needs ingredients that directly target breakouts and blemishes.

### Can I use this serum with retinol, and in what order?

You can use this serum alongside retinol by applying the retinol first, letting it absorb, and then following with this treatment, though this skin often benefits more from gentle, dedicated blemish-fighting ingredients and soothing hydrators that directly target breakouts.

### How often should I use this serum?

Start using this serum once a week in the evening, and if your skin feels comfortable and looks good, you may carefully use it more often. This gentle approach helps prevent irritation while smoothing your skin texture and balancing oil.

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is unlikely to cause breakouts or clog pores on oily skin because it has a safe formulation with soothing ingredients like lavender oil to keep irritation low. However, because its primary focus is not directly addressing acne and breakouts, this skin type needs a product that includes targeted blemish-fighting ingredients and oil-balancing agents.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — $25.08 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — $25.08 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $68.00 (https://www.amazon.com/dp/B085X9YB53?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Acacia Senegal Gum, Caprylic Capric Triglyceride, Cetearyl Alcohol, Cetearyl Olivate, Ethylhexylglycerin, Glycerin, Lactic Acid, Lavandula Angustifolia Oil Lavender Oil, Lespedeza Capitata Stem Extract Leaf, Linalool, Phenoxyethanol, Polyacrylate Crosspolymer-6, Propanediol, Sodium Gluconate, Sodium Hydroxide, Sorbitan Olivate, Squalane, Water, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin