# Biossance Squalane + Lactic Acid Resurfacing Night Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Biossance](https://lovi.care/skincare/brands/biossance)
Category: [Exfoliants](https://lovi.care/skincare/best/exfoliators)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other products fit it better.

## Why this fit

- Offers moderate exfoliation for your combination skin, as lactic acid helps smooth texture and squalane provides emollient action to balance hydration.
- While beneficial for general skincare, the lactic acid offers mild exfoliation that is supportive but not specifically targeted for managing oily shine on combination skin.
- The formula is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Squalane, Lactic Acid, Glycerin, Lavender Oil, Acacia Senegal Gum

## What the research says

- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Polysaccharide-based O/W emulsions incorporated with lavender essential oil applied to cellulosic support are non-irritating, provide softness and moisturizing effects, and are safe for topical patch applications. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34547316/))
- Gellan gum hydrogel films co-encapsulating ofloxacin with tea tree or lavender oil achieved 98% wound contraction and completely healed epidermis in rats after ten days of treatment compared to baseline. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/33130262/))
- Topical application of lavender oil significantly promoted wound contraction, collagen synthesis, and fibroblast differentiation with up-regulation of TGF-beta in a rat model compared to control. ([BMC Complementary and Alternative Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/27229681/))
- Acacia gum and carbopol hydrogel wound dressings containing gentamicin showed faster wound healing, well-developed fibroblasts, and blood capillaries compared to open wounds in swiss albino mice. ([International Journal of Pharmaceutics, 2013](https://pubmed.ncbi.nlm.nih.gov/24075861/))
- Barley beta-glucan films formulated with sorbitol and acacia gum demonstrated suitable mechanical properties and stimulated in vitro keratinocytes growth. ([International Journal of Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/37028573/))
- Gum arabic and beta-cyclodextrin microencapsulated peony seed oil emulsion protected against ultraviolet radiation by inhibiting reactive oxygen species generation, increasing cell viability from 54.75% to 92.69% in UVB-damaged HaCaT cells, and repairing 95.56% of UVB-damaged skin within 7 days in animal experiments through regulation of the NF-kappaB signaling pathway. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41734836/))

## Why other products fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Based on a very large amount of data, this serum is highly effective at smoothing rough texture and brightening dull skin, often overnight, without causing dryness. Most users, including those with sensitive skin, find it gentle and hydrating. A moderate number of users dislike the herbal scent and find the product expensive, while a low number report experiencing irritation or breakouts.

- Liked: Smoothes skin texture (mostly mentioned)
- Liked: Brightens complexion (often mentioned)
- Liked: Gentle and hydrating (often mentioned)
- Liked: Fades dark spots (sometimes noted)
- Disliked: Herbal scent disliked (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Causes irritation (rarely noted)

## How to apply

- Use this exfoliant product in your PM routine starting once a week, then increase frequency carefully if your skin feels fine.
- Apply this exfoliant step after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the exfoliant into your skin and wait a minute before layering.
- Apply the exfoliant to clean, dry skin to help control your oily shine comfortably.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/028e5e793422a3b665c02ff502cf5a68.mp4

## Questions and answers

### How well does Biossance Squalane + Lactic Acid Resurfacing Night Serum work for combination skin?

This serum works moderately well for your combination skin, as lactic acid helps smooth texture while squalane balances hydration. However, it is not specifically targeted for managing oily shine on combination skin. A top-rated product for this skin type needs ingredients like niacinamide and zinc PCA to regulate oiliness and enhance radiance without causing irritation.

### Which ingredients make this serum a good fit for combination skin?

Lactic acid helps smooth texture and squalane provides moisture to balance dry and oily areas on your combination skin. To fit this skin even better, an exfoliant treatment needs ingredients like niacinamide and zinc PCA to regulate oiliness.

### What does Squalane do for combination skin?

Squalane helps keep combination skin soft and smooth by locking in moisture without feeling heavy or greasy. It supports the skin barrier and provides lightweight hydration that works well for both dry and oily areas.
Sources: [Skin Health and Disease, 2024](https://pubmed.ncbi.nlm.nih.gov/39355739/), [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/)

### What does Lactic Acid do for combination skin?

Lactic acid helps balance combination skin by gently removing dead surface cells and managing oil while keeping moisture locked in. It is unlikely to cause irritation when used properly, and instead supports a smooth, clear, and well-hydrated complexion across both oily and dry areas. This type of skin needs ingredients that gently clear pores without stripping natural moisture, such as balanced hydrators and mild exfoliants.
Sources: [Frontiers in Physiology, 2026](https://pubmed.ncbi.nlm.nih.gov/42326996/), [Clinical, Cosmetic and Investigational Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39050562/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing. Start using it once a week, and use it more often only if your skin handles it well. Combination skin needs products that exfoliate gently while controlling oily shine and balancing hydration.

### Can I use this serum with retinol, and in what order?

It is best not to use this lactic acid serum in the same routine as retinol, as combining two strong treatments may easily cause skin irritation. Instead, alternate them on different nights or use retinol on nights when you skip this serum.

### How often should I use this serum?

Start by using this serum once a week in your evening routine, and if your skin tolerates it well and sees good results, you may carefully use it more often. This type of product needs ingredients that balance hydration and gentle exfoliating acids to properly smooth combination skin without causing irritation.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts on your combination skin, though reviewers occasionally report mild breakouts. It helps smooth texture and balance hydration safely, but a product for this skin needs ingredients that specifically target oily shine.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — $16.75 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — $28.88 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — $200.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/combination-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $68.00 (https://www.amazon.com/dp/B085X9YB53?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Acacia Senegal Gum, Caprylic Capric Triglyceride, Cetearyl Alcohol, Cetearyl Olivate, Ethylhexylglycerin, Glycerin, Lactic Acid, Lavandula Angustifolia Oil Lavender Oil, Lespedeza Capitata Stem Extract Leaf, Linalool, Phenoxyethanol, Polyacrylate Crosspolymer-6, Propanediol, Sodium Gluconate, Sodium Hydroxide, Sorbitan Olivate, Squalane, Water, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-lactic-acid-resurfacing-night-serum/for/combination-skin