# Biossance Squalane + Ectoin Overnight Rescue for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Biossance](https://lovi.care/skincare/brands/biossance)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for normal skin as squalane and glycerin provide emollient and humectant actions, supporting skin hydration and barrier function.
- Excellent benefits for wrinkles and fine lines are offered due to Acetyl Hexapeptide-8, which supports anti-aging.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of harsh ingredients and the presence of soothing ingredients like Ectoin and Squalane.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/oily-acne-prone-skin): Average

## Key ingredients

Squalane, Ectoin, Glycerin, Shorea Stenoptera Seed Butter, Acetyl Hexapeptide-8

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Combining ectoine and mannitol with UV filters significantly improved protection of squalene oxidation, catalase activity, and trans-UCA compared to UV filters alone in 10 subjects on irradiated areas. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37539499/))
- Topical 7% ectoine during serial 1064-nm Nd:YAG laser therapy produced a greater reduction in skin erythema, improved stratum corneum hydration, reduced transepidermal water loss, and decreased low-echogenic pixels in thirty participants compared to a vehicle control. ([Biomedicines, 2026](https://pubmed.ncbi.nlm.nih.gov/42792808/))
- Regular application of a novel anti-ageing cream containing hyaluronic acid, ectoin, and botanical actives significantly reduced wrinkle depth and length in the periorbital area while demonstrating very good skin tolerance. ([Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))

## What reviewers say

Most users report waking up to soft, plump, and soothed skin without irritation. Those with oily or acne-prone skin occasionally find the formula too rich. This summary is based on a very large amount of data and should definitely be taken into account.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Absorbs well (often mentioned)
- Liked: Plumps and softens (often mentioned)
- Liked: Soothes sensitive skin (often mentioned)
- Disliked: High price point (sometimes noted)
- Disliked: Heavy or greasy (rarely noted)
- Disliked: Jar packaging (rarely noted)
- Disliked: May cause breakouts (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Biossance Squalane + Ectoin Overnight Rescue a great fit for mature skin?

Biossance Squalane + Ectoin Overnight Rescue is a great fit for mature skin because it contains Acetyl Hexapeptide-8 to help smooth out fine lines and wrinkles. It also includes squalane and glycerin to deeply hydrate and keep the skin soft, while soothing ingredients like ectoin help prevent irritation.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### Which ingredients make this cream a good fit for mature skin?

Acetyl Hexapeptide-8 makes this cream a great fit for mature skin by helping smooth out wrinkles and fine lines. Squalane, glycerin, and ectoin also support your skin by boosting hydration and keeping it calm and smooth.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Squalane do for mature skin?

Squalane helps keep mature skin feeling soft and smooth by boosting moisture and protecting the skin barrier. It also provides antioxidant support that helps improve the look of fine lines and wrinkles over time.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Journal of Nanoscience and Nanotechnology, 2010](https://pubmed.ncbi.nlm.nih.gov/21137794/)

### What does Ectoin do for mature skin?

For mature skin, ectoin helps keep skin hydrated and smooth while supporting firmness and protecting against everyday damage. It helps improve moisture levels and preserves collagen, which is especially beneficial since mature skin tends to become dry and lose its bounce.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/41116229/)

### Where does this cream go in a skincare routine for mature skin?

This moisturizing treatment goes in your evening routine after cleansing and before your final moisturizer. It helps smooth mature skin and reduce fine lines using ingredients that are very well tolerated.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying your retinol first, letting it absorb, and then following with this treatment to keep your mature skin soft and calm. Using a barrier-supporting moisturizer helps reduce the dryness and irritation that often come with retinol use.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/)

### How often should I use this cream?

This moisturizing treatment is a great fit for your mature skin and is designed to be used in the evening. Daily application helps improve hydration and reduces the appearance of fine lines and wrinkles while keeping your skin calm.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to cause breakouts for mature skin because it has a very low risk of clogging pores and features soothing ingredients like squalane and ectoin. It does not contain ingredients that typically cause skin purging.

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because the skin around the eyes is thin and the product has an excellent safety profile without harsh ingredients. It helps smooth lines and keeps dry skin soft and plump.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Medi-Peel Peptide 9 Volume Tox Cream](https://lovi.care/skincare/p/medi-peel/peptide-9-volume-tox-cream/for/mature-skin) — Superior fit — $21.55 at Amazon
- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/mature-skin) — Superior fit — $125.00 at Amazon
- [StriVectin SD Advanced Plus Intensive Moisturizing Concentrate](https://lovi.care/skincare/p/strivectin/sd-advanced-plus-intensive-moisturizing-concentrate/for/mature-skin) — High fit — $149.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- SPF: [ISDIN Eryfotona Actinica SPF 50+](https://lovi.care/skincare/p/isdin/eryfotona-actinica-spf-50/for/mature-skin) — Superior fit — $46.00 at Amazon

## Where to buy

- Amazon.com: $70.00 (https://www.amazon.com/dp/B0CVR4G674?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Glycerin, Squalane, Shorea Stenoptera Seed Butter, Caprylic Capric Triglyceride, C12-16 Alcohols, Sodium Acrylates Copolymer, Ectoin, Jojoba Esters, Acetyl Hexapeptide-8, Magnesium Chloride, Palmitic Acid, Hydrogenated Lecithin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Lecithin, Sorbitan Isostearate, Tocopherol, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Sodium Gluconate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin
- France: https://lovi.care/skincare/fr/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/squalane-ectoin-overnight-rescue/for/mature-skin