# Biossance 100% Squalane Oil for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: Average · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/p/biossance/100-squalane-oil/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Biossance](https://lovi.care/skincare/brands/biossance)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other products fit it better.

## Why this fit

- Offers moderate moisturizing for your oily skin, as squalane provides emollient action to hydrate and enhance barrier resilience without significant oil control.
- While beneficial for general hydration, the formula lacks targeted ingredients to effectively address your acne, blemishes, and breakouts.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/biossance/100-squalane-oil/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/biossance/100-squalane-oil/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/biossance/100-squalane-oil/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/biossance/100-squalane-oil/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/biossance/100-squalane-oil/for/acne-prone-skin): Low
- [Skin with dark spots](https://lovi.care/skincare/p/biossance/100-squalane-oil/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/biossance/100-squalane-oil/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/biossance/100-squalane-oil/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/biossance/100-squalane-oil/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Squalane, Squalane Oil

## What the research says

- Topical application of a vitamin C-squalene bioconjugate significantly increased epidermal thickness, type III collagen production, and glycosaminoglycans production in human skin explants compared to free vitamin C and vitamin C-palmitate. ([Scientific Reports, 2020](https://pubmed.ncbi.nlm.nih.gov/33037252/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Application of squalene/phosphotungstate calcium nanowires (Sql/PWC) oleogel on UVB-irradiated skin decreased epidermal thickness, increased dermal thickness, and promoted the expression of elastin, collagen, and skin barrier markers through antioxidant and anti-inflammatory activities. ([Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## Why other products fit oily acne-prone skin better

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))
- A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35763437/))

## What reviewers say

This sugarcane-derived oil is widely praised as a "holy grail" for its lightweight, non-greasy texture that mimics the skin's natural moisture. Users with sensitive and acne-prone skin frequently report that it hydrates without clogging pores, while many appreciate its versatility as a multi-purpose treatment for face, body, and hair. This summary is based on a very large amount of data and should definitely be taken into account.

- Liked: Lightweight non-greasy (mostly mentioned)
- Liked: Multi-purpose versatility (often mentioned)
- Liked: Softens skin texture (often mentioned)
- Liked: Soothing gentle (sometimes noted)
- Disliked: Packaging pump issues (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Insufficient hydration (rarely noted)
- Disliked: Price point (rarely noted)

## Questions and answers

### How well does Biossance Squalane Oil work for oily acne-prone skin?

Biossance Squalane Oil works moderately well for oily acne-prone skin by providing basic moisture and strengthening the skin barrier, but it lacks ingredients to target breakouts. An ideal product for this skin type needs lightweight hydrating ingredients, soothing extracts, and blemish-fighting agents to manage oil and clear breakouts without clogging pores.

### Which ingredients make this oil a good fit for oily acne-prone skin?

Squalane makes this oil a moderate fit for oily skin by providing gentle hydration and strengthening your skin barrier without heavy oils. However, this product lacks targeted ingredients to address blemishes and breakouts. Oily acne-prone skin needs lightweight, non-clogging formulas with powerful acne-fighting ingredients, brightening agents, soothing extracts, peptides, and oil-controlling properties.
Sources: [Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/), [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/)

### What does Squalane do for oily acne-prone skin?

Squalane may help keep oily skin soft and smooth, but oxidized squalene can trigger inflammation in acne-prone skin. Because of this, oily acne-prone skin needs lightweight, non-greasy ingredients that balance moisture without clogging pores.
Sources: [The Journal of Investigative Dermatology, 2006](https://pubmed.ncbi.nlm.nih.gov/16778793/)

### What does Squalane Oil do for oily acne-prone skin?

Squalane oil helps keep oily acne-prone skin soft and smooth without feeling heavy or greasy. Because it closely mimics your skin's natural oils, it is unlikely to clog pores, and it helps calm redness while supporting a balanced skin barrier.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Journal of the American Academy of Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37315800/)

### Where does this oil go in a skincare routine for oily acne-prone skin?

Biossance 100% Squalane Oil goes near the end of your morning or evening routine, right before sunscreen in the day or as your moisturizer step at night. Because it provides moderate hydration without oil control or blemish-fighting ingredients, an oily acne-prone skin type needs targeted blemish-clearing ingredients and lightweight hydrators instead.

### Can I use this oil with retinol, and in what order?

You can use this oil with retinol by applying the oil after your retinol to help keep your skin soft and comfortable. This may reduce dryness and irritation while you use retinol, though a product of this type for oily acne-prone skin also needs targeted ingredients to clear breakouts.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24930436/)

### How often should I use this oil?

You can use this oil daily to hydrate your oily skin, though an oily acne-prone skin needs a product with targeted blemish-clearing ingredients to better fit its specific needs.

### Can this oil clog pores, cause breakouts or purging for oily acne-prone skin?

This oil is unlikely to clog pores since it has a light texture, but some users with oily acne-prone skin may experience breakouts because the formula lacks ingredients that target blemishes. A product for this skin needs oil-controlling and pore-clearing ingredients to keep breakouts away.

## Alternatives for oily acne-prone skin

- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/p/cosrx/advanced-snail-96-mucin-power-essence/for/oily-acne-prone-skin) — Superior fit — $15.88 at Amazon
- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/oily-acne-prone-skin) — Superior fit — $15.50 at Amazon
- [Drunk Elephant Protini Polypeptide Cream](https://lovi.care/skincare/p/drunk-elephant/protini-polypeptide-cream/for/oily-acne-prone-skin) — High fit — $49.95 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — $25.60 at Amazon
- Moisturizer: [COSRX Oil-Free Ultra-Moisturizing Lotion with Birch Sap](https://lovi.care/skincare/p/cosrx/oil-free-ultra-moisturizing-lotion-with-birch-sap/for/oily-acne-prone-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $34.00 (https://www.amazon.com/dp/B07658MRWW?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Squalane, Squalane Oil
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/biossance/100-squalane-oil/for/oily-acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/biossance/100-squalane-oil/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/biossance/100-squalane-oil/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/biossance/100-squalane-oil/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/biossance/100-squalane-oil/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/biossance/100-squalane-oil/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/biossance/100-squalane-oil/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/biossance/100-squalane-oil/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/biossance/100-squalane-oil/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/biossance/100-squalane-oil/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/biossance/100-squalane-oil/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/biossance/100-squalane-oil/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/biossance/100-squalane-oil/for/oily-acne-prone-skin