# Bioderma Hydrabio Serum for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/bioderma/hydrabio-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Bioderma](https://lovi.care/skincare/brands/bioderma)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few moisturizers fit it even better.

## Why this fit

- Offers moderate moisturizing for your normal skin with sensitivity, as glycerin and sodium hyaluronate hydrate and plump without irritation.
- Niacinamide and Laminaria Ochroleuca Extract effectively soothe redness and reduce inflammation, addressing your primary concerns.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/bioderma/hydrabio-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/bioderma/hydrabio-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/bioderma/hydrabio-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/bioderma/hydrabio-serum/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/p/bioderma/hydrabio-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/bioderma/hydrabio-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/bioderma/hydrabio-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/bioderma/hydrabio-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/bioderma/hydrabio-serum/for/oily-acne-prone-skin): High

## Key ingredients

Aquagenium Patent, Sodium Hyaluronate, Niacinamide, Glycerin, Laminaria Ochroleuca Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on a very large amount of data, users consistently praise this serum for its lightweight, gel-like texture that delivers deep hydration without leaving a sticky residue, making it ideal for dehydrated and sensitive skin. While most find it plumps and smooths the complexion effectively, those with extremely dry skin often note it works best when layered under a richer moisturizer rather than as a standalone solution.

- Liked: Lightweight & fast-absorbing (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Excellent makeup base (sometimes noted)
- Liked: Sensitive skin friendly (sometimes noted)
- Disliked: Fragrance presence (sometimes noted)
- Disliked: Price vs. size (sometimes noted)
- Disliked: Availability issues (rarely noted)
- Disliked: Not enough for dry skin (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Bioderma Hydrabio Serum a great fit for sensitive skin?

Bioderma Hydrabio Serum is a great fit because glycerin and sodium hyaluronate hydrate and plump your skin without causing irritation, while niacinamide and Laminaria Ochroleuca Extract help soothe redness. Its safety profile is excellent since it contains no harsh ingredients that might trigger sensitivity.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for sensitive skin?

Glycerin and sodium hyaluronate hydrate and plump your skin without causing irritation, while niacinamide and Laminaria Ochroleuca extract soothe redness and calm inflammation. This serum has an excellent safety profile and is unlikely to irritate sensitive skin because it lacks harsh ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Aquagenium Patent do for sensitive skin?

Aquagenium Patent helps reactive skin stay comfortable by supporting moisture channels so water is held better within the surface layers. This ingredient blend works to keep dry areas soft and calm while reducing water loss.
Sources: [Skin Pharmacology and Physiology, 2012](https://pubmed.ncbi.nlm.nih.gov/22584263/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in the evening routine, placed after your cleanser and soothing toner and before your moisturizer. Putting this treatment in the evening helps keep your routine simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol to help keep your skin calm and hydrated. Apply the serum after your retinol absorbs, or use it first as a buffer to lower the likelihood of irritation.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this serum?

Apply this serum in your evening routine, as treatments fit best there for simplicity and extra safety around sun exposure. Some people may also use it in the morning or twice a day.

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin because it is formulated without heavy, pore-clogging ingredients. Its lightweight texture hydrates and calms without irritation, making it safe for daily use on reactive skin.

### Can I use this serum around the eyes or on my body?

Bioderma Hydrabio Serum is a great fit for sensitive skin and can be used on delicate areas like around the eyes and on the body because its gentle ingredients hydrate and soothe without causing irritation. The skin around the eyes and on certain body areas is particularly thin, making it well-suited for soothing moisturizers that lack harsh ingredients.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum).

## Alternatives for sensitive skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/sensitive-skin) — Superior fit — $22.00 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/p/cosrx/advanced-snail-96-mucin-power-essence/for/sensitive-skin) — Superior fit — $15.88 at Amazon
- [COSRX Advanced Snail 92 All in One Cream](https://lovi.care/skincare/p/cosrx/advanced-snail-92-all-in-one-cream/for/sensitive-skin) — Superior fit — $16.50 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — $28.08 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — $28.05 at Amazon
- Moisturizer with Sun Protection: [innisfree Daily Mild Sunscreen](https://lovi.care/skincare/p/innisfree/daily-mild-sunscreen/for/sensitive-skin) — Superior fit — $18.00 at Amazon

## Where to buy

- Amazon.com: $37.99 (https://www.amazon.com/dp/B002WZGFWS?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Xylitol, Sodium Polyacrylate, Mannitol, Rhamnose, Fructooligosaccharides, Laminaria Ochroleuca Extract, Niacinamide, Pyrus Malus Fruit Extract, Dimethicone, Cyclopentasiloxane, Trideceth-6, Peg Ppg-18 18 Dimethicone, Sodium Hyaluronate, Hexyldecanol, Caprylic Capric Triglyceride, Disodium Edta, Chlorphenesin, Phenoxyethanol, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/bioderma/hydrabio-serum/for/sensitive-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/bioderma/hydrabio-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/bioderma/hydrabio-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/bioderma/hydrabio-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/bioderma/hydrabio-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/bioderma/hydrabio-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/bioderma/hydrabio-serum/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/bioderma/hydrabio-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/bioderma/hydrabio-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/bioderma/hydrabio-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/bioderma/hydrabio-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/bioderma/hydrabio-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/bioderma/hydrabio-serum/for/sensitive-skin