AXIS-Y Vegan Collagen Eye Serum for mature skin

Questions and answers

What the research says

• Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects.

  International Journal of Cosmetic Science, 2005

• A functionalized dendrimer nanocarrier delivers active ingredients into the dermis and enhances collagen production in human dermal fibroblasts by co-delivering all-trans retinol and palmitoyl pentapeptide-4.

  Acta Biomaterialia, 2025

• Polyelectrolyte nanocomplexes of quaternized cyclodextrin grafted chitosan and low molecular weight hyaluronic acid improved skin texture and elasticity by increasing skin hydration in clinical evaluation.

  Colloids and Surfaces. B, Biointerfaces, 2022

• Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone.

  Dermatologic Therapy, 2022

• Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements.

  Indian Journal of Pharmaceutical Sciences, 2016

• Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.

  Journal of Cosmetic Dermatology, 2022

• Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.

  International Journal of Molecular Sciences, 2022

• Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.

  Marine Drugs, 2023

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

Ingredients

Water, Methylpropanediol, Glycerin, 1,2-Hexanediol, Niacinamide, Adenosine, Collagen, Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Tripeptide-1, Palmitoyl Pentapeptide-4, Hexapeptide-9, Acetyl Hexapeptide-8, Copper Tripeptide-1, Pyrus Malus Fruit Extract, Prunus Mume Fruit Extract, Vitis Vinifera Fruit Extract Grape Fruit Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Jojoba Seed Oil, Limnanthes Alba Seed Oil, Carica Papaya Fruit Extract, Centella Asiatica Extract, Ficus Carica Fruit Extract, Ulmus Davidiana Root Extract, Amaranthus Caudatus Seed Extract, Ceramide Np, Hydrogenated Lecithin, Leuconostoc Radish Root Ferment Filtrate, Butylene Glycol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, C13-14 Alkane, Sodium Acrylic Acid Ma Copolymer, C15-23 Alkane, Ethylhexylglycerin, Decyl Glucoside, Caprylyl Glycol, Polyglyceryl-10 Stearate, Tocopherol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.