# AXIS-Y Artichoke Intensive Skin Barrier Ampoule for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [AXIS-Y](https://lovi.care/skincare/brands/axis-y)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for dry skin due to the presence of humectants like sodium hyaluronate and glycerin, which provide some hydration but may not be sufficient for optimal results.
- The formula includes centella asiatica extract for barrier support, which is beneficial for dry skin, but the overall hydration may not fully address flakiness.
- The safety profile is excellent, with no risks of irritation for your dry skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Cynara Scolymus Extract, Sodium Hyaluronate, Centella Asiatica Extract, Glycerin, Glycyrrhiza Glabra Root Extract Licorice Root Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- An artichoke extract cosmetic formulation enhanced skin roughness by 19.74% and elasticity by 11.45% in human subjects compared to a placebo cream, alongside exhibiting antioxidant, anti-inflammatory, and anti-aging cellular effects. ([Molecules, 2018](https://pubmed.ncbi.nlm.nih.gov/30360471/))
- Luteolin inhibited the mRNA expression of antimicrobial peptides and increased cornified envelope proteins in TNF-alpha/IL-17A/IFN-gamma-stimulated HaCaT cells by regulating the TRAF6/IkappaB/NF-kappaB signaling pathway. ([Food Science and Biotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40655288/))
- Antioxidants and luteolin topically applied decrease UV-B induced apoptosis and downregulate pro-inflammatory cytokines in kindler syndrome keratinocyte cultures. ([Human Molecular Genetics, 2016](https://pubmed.ncbi.nlm.nih.gov/27798104/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))

## Why other moisturizers fit dry skin better

- Aged Punica granatum extract significantly reduced UV-induced erythema and melanin levels while improving skin hydration and lightness compared to placebo in 60 women. ([Food Science & Nutrition, 2025](https://pubmed.ncbi.nlm.nih.gov/40755496/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))

## What reviewers say

This ampoule is widely praised as a lightweight, fast-absorbing treatment that excels at soothing irritated skin and repairing a damaged moisture barrier, particularly for oily, acne-prone, and sensitive skin types. Users frequently note that while it provides excellent hydration and redness relief without stickiness, those with very dry skin often need to layer it with a heavier moisturizer.

- Liked: Soothing & calming (mostly mentioned)
- Liked: Hydrating (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Barrier repair (sometimes noted)
- Disliked: Not moisturizing enough (sometimes noted)
- Disliked: Small size/price (sometimes noted)
- Disliked: Alcohol content (rarely noted)
- Disliked: Breakouts/reaction (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using it 3 times a week and work your way up to daily use.
- Apply your moisturizer after your toner and before your sunscreen in the morning. At night, use it as the final step after your serum.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing to keep your dry skin happy.
- Apply the moisturizer on slightly damp skin to help lock in extra hydration. This is great for soothing dry and flaky areas .
- Avoid the sensitive eye area and do a patch test before your first use .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does AXIS-Y Artichoke Ampoule work for dry skin?

This ampoule works moderately well for dry skin, offering some hydration and barrier support through ingredients like sodium hyaluronate, glycerin, and centella asiatica extract, but it may not fully address flakiness. It is unlikely to cause irritation. To properly care for dry skin, a moisturizing treatment of this type needs richer moisturizing agents and nourishing extracts that lock in deep moisture and enhance moisture retention.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for dry skin?

Sodium hyaluronate and glycerin help pull in moisture, while centella asiatica extract helps support your skin barrier. To truly satisfy dry skin, a product of this type needs richer hydrating agents and nourishing extracts that lock in deep moisture and fully smooth away flakiness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Artichoke Extract do for dry skin?

Artichoke extract helps smooth dry skin and improves its overall elasticity. It also provides antioxidant and anti-aging benefits that keep the skin looking healthy.
Sources: [Molecules, 2018](https://pubmed.ncbi.nlm.nih.gov/30360471/), [Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/39203039/)

### What does Hyaluronic Acid do for dry skin?

Hyaluronic acid draws moisture into dry skin, giving an immediate and lasting boost in hydration that helps smooth out fine lines and soften rough patches. It is very gentle and unlikely to cause irritation while improving overall skin smoothness and plumpness.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this serum go in a skincare routine for dry skin?

This serum goes in your evening routine after cleansing and before moisturizing. Dry skin needs richer hydrators and heavy oils or butters to lock in moisture and fully stop flakiness.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol. Dry skin needs richer hydrators and barrier-protecting ingredients like ceramides or rich oils to keep flakiness away.

### How often should I use this serum?

You can use this serum in the evening as part of your routine. It is unlikely to irritate dry skin, but dry skin needs richer ingredients and heavier moisturizers to fully stop flakiness.

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to cause breakouts or clogged pores for dry skin, as it has an excellent safety profile without harsh ingredients.

### Can I use this serum around the eyes or on my body?

You can use this serum around your eyes and on your body, as it has a very safe formula with no harsh ingredients. However, because dry skin needs deeper moisture and rich heavy creams or oils to fully stop flakiness, this lightweight treatment may not be enough on its own.

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for dry skin

- [su:m37º Secret Essence Double Concentrate](https://lovi.care/skincare/p/su-m37o/secret-essence-double-concentrate/for/dry-skin) — Superior fit — $29.99 at Amazon
- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/p/revision-skincare/hydrating-serum/for/dry-skin) — High fit — $109.00 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/dry-skin) — High fit — $19.99 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — $19.99 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/p/pyunkang-yul/calming-deep-moisture-toner/for/dry-skin) — Superior fit — $16.99 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/p/d-alba/piedmont-waterfull-mild-sunscreen/for/dry-skin) — Superior fit — $15.99 at Amazon

## Where to buy

- Amazon.com: $17.99 (https://www.amazon.com/dp/B08Z7Z1FH6?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 4 Nov 2026.

## Ingredients

Water, Aloe Barbadensis Leaf Water, Butylene Glycol, Sodium Hyaluronate, Centella Asiatica Extract, Glycerin, Betaine, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Alcohol, Cynara Scolymus Extract, Sorbitol, Sorbitan Sesquioleate, Hieracium Pilosella Extract, Rheum Palmatum Root Extract, Althaea Rosea Flower Extract, Aloe Barbadensis Leaf Extract, Dimethyl Sulfone, Chlorphenesin, Xanthan Gum, Peg-60 Hydrogenated Castor Oil, Ethylhexylglycerin, Polyglutamic Acid, Beta-Glucan, Arginine, Linum Usitatissimum Seed Extract, Hibiscus Esculentus Fruit Extract, Aloe Barbadensis Leaf Juice, Arctium Lappa Root Extract, Hibiscus Mutabilis Flower Extract, Corchorus Olitorius Leaf Extract, Allantoin, Carbomer, Adenosine, Melaleuca Alternifolia Tree Oil Leaf
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin
- France: https://lovi.care/skincare/fr/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/axis-y/artichoke-intensive-skin-barrier-ampoule/for/dry-skin