# Avène Cleanance Comedomed for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/p/avene/cleanance-comedomed/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Avène](https://lovi.care/skincare/brands/avene)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate exfoliation for your normal skin due to salicylic acid and glycolic acid, which help reduce acne lesions and blemishes, but lacks specialized ingredients like retinoids or peptides to effectively target your wrinkles and fine lines.
- The formula includes soothing ingredients such as Dipotassium Glycyrrhizate and Tocopherol, providing general skincare benefits that are supportive but not primary for your concerns.
- The product is safe for your normal skin, with no risks of irritation due to the absence of harsh ingredients and the presence of beneficial components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/avene/cleanance-comedomed/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/avene/cleanance-comedomed/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/p/avene/cleanance-comedomed/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/avene/cleanance-comedomed/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/avene/cleanance-comedomed/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/p/avene/cleanance-comedomed/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/avene/cleanance-comedomed/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/p/avene/cleanance-comedomed/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/p/avene/cleanance-comedomed/for/oily-acne-prone-skin): High

## Key ingredients

Salicylic Acid, Glycolic Acid, Zinc Gluconate, Silybum Marianum Fruit Extract, Pumpkin Seed Oil

## What the research says

- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Twice daily application of a multitargeted dermocosmetic cream provided comparable efficacy to benzoyl peroxide 5% gel in reducing inflammatory, non-inflammatory, and total lesions in 150 Caucasian subjects with mild-to-moderate acne over 56 days, while demonstrating superior skin tolerability. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/))
- The use of a salicylic acid-based dermocosmetic significantly reduces the needed quantity of benzoyl peroxide without impacting efficacy in mild to moderate acne, and as maintenance post-benzoyl peroxide allows a significant reduction of acne relapse compared to vehicle. ([Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/38051857/))
- A topical formulation containing panthenol, niacinamide, and dipotassium glycyrrhizate increased skin hydration by 74.1% and reduced transepidermal water loss by 13.5% at 28 days compared to baseline and untreated control in 35 individuals with xerosis. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical 5% benzoyl peroxide plus salicylic acid achieved the greatest lesion reduction at early 2 to 4 week time points compared to benzoyl peroxide, clindamycin, and combination benzoyl peroxide/clindamycin, while 5% benzoyl peroxide plus salicylic acid and combination benzoyl peroxide/clindamycin showed similar efficacy at 10 to 12 weeks in acne patients. ([Journal of the American Academy of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20488582/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))
- A dermocosmetic cream containing Punica granatum Pericarp extract, Salicylic acid, Niacinamide, Zinc gluconate, and Aqua Posae Filiformis significantly decreased inflammatory, non-inflammatory, and total lesion counts in subjects with mild to moderate acne compared to untreated hemi-faces after 15 days. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41487026/))
- Daily use of a deep cleansing gel containing salicylic acid 2%, zinc gluconate 0.2% and lipohydroxy acid 0.05% significantly reduced total lesion count by 56.3% after 84 days in 35 subjects with mild to moderate truncal acne. ([Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36698447/))
- Different strains of Propionibacterium acnes modulate cutaneous innate immunity with varying pro-inflammatory potentials, with P. acnes type III showing the highest and P. avidum the weakest, and zinc gluconate down-regulates the expression of most induced immune markers. ([Experimental Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23947673/))
- Silybum marianum flower extract increased human hair follicle dermal papilla cell proliferation and VEGF production while suppressing cellular senescence, and in a clinical study using hair shampoo, it significantly increased hair density and total hair count at 16 and 24 weeks compared with a placebo group. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37675655/))
- Topical 0.5% silymarin-loaded antioxidant serum applied twice daily significantly reduced clinical acne severity, lesion counts, and melanin pigmentation in 22 Korean acne patients over 4 weeks without associated adverse events. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36204969/))
- Topical silymarin cream 1.4% showed comparable results to salicylic acid 30% peels in reducing acne severity in 30 patients with mild to moderate acne vulgaris. ([Journal of Cutaneous Medicine and Surgery, 2024](https://pubmed.ncbi.nlm.nih.gov/37942562/))
- Topical treatment with pumpkin seed oil healed uniform wounds in rats, achieving full re-epithelialization, reappearance of skin appendages, and well-organized collagen fibers compared to untreated controls. ([Lipids in Health and Disease, 2016](https://pubmed.ncbi.nlm.nih.gov/27068642/))
- A combinational sunscreen formulation of UV filters, melatonin, and pumpkin seed oil ameliorated UV radiation-induced photoaging in adult Wistar albino rats by increasing SOD, GSH-Px, CAT, and collagen levels, while decreasing skin edema, skin thickness, and inflammatory cytokines compared to UV-exposed controls. ([European Journal of Pharmaceutical Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/30414837/))
- Topical pumpkin seed oil increased hair follicle proliferation in mice without causing liver toxicity, oxidative stress, or genotoxicity. ([Acta Histochemica, 2022](https://pubmed.ncbi.nlm.nih.gov/35447441/))

## Why other serums fit mature skin better

- Topical application of retinol and retinoic acid both increased epidermal thickness and upregulated collagen genes and proteins in human skin, with retinol producing similar histological and molecular changes to retinoic acid alongside a significant reduction in facial wrinkles after 12 weeks. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26578346/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))

## What reviewers say

This treatment is frequently praised for its effectiveness on oily, blemish-prone, and sensitive skin, particularly in managing blackheads and closed comedones, with many users reporting clearer skin and fewer breakouts. A significant number of users also appreciate its lightweight texture and matte finish. Some users note a strong chemical scent and a drying effect, with a few experiencing irritation or a sticky consistency.

- Liked: Reduces blemishes (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: Strong chemical scent (often mentioned)
- Liked: Matte finish (sometimes noted)
- Liked: Prevents recurrence (sometimes noted)
- Disliked: Drying effect (sometimes noted)
- Disliked: Can cause irritation (rarely noted)
- Disliked: Sticky consistency (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Cleanance Comedomed work for mature skin?

Avene Cleanance Comedomed works for mature skin by offering moderate exfoliation to help keep it smooth, though it lacks specialized ingredients like retinoids or peptides to effectively target wrinkles and fine lines. A product for this skin needs high-quality anti-aging ingredients, potent antioxidants, hydrating components, and skin-repairing ingredients like peptides to deliver optimal results.

### Which ingredients make this treatment a good fit for mature skin?

Salicylic acid and glycolic acid make this treatment a fit for mature skin by offering moderate exfoliation to help reduce blemishes, while soothing components provide general support. However, because it lacks specialized ingredients for lines and wrinkles, a product of this type needs retinoids, peptides, antioxidants, hydrating components, and nourishing oils to truly benefit mature skin.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/)

### What does Salicylic Acid do for mature skin?

Salicylic acid helps smooth and firm mature skin by boosting collagen and elasticity while reducing roughness and wrinkles. It is unlikely to cause irritation when used correctly, but this skin type also needs extra hydrating ingredients to stay soft and plump.
Sources: [Aesthetic Plastic Surgery, 2025](https://pubmed.ncbi.nlm.nih.gov/38926250/)

### What does Glycolic Acid do for mature skin?

Glycolic acid helps smooth mature skin by encouraging fresh skin renewal and supporting firmness. It may also help improve signs of photoaging and increase moisture levels over time.
Sources: [Dermatologic Surgery, 1998](https://pubmed.ncbi.nlm.nih.gov/9793513/), [Acta Medica, 2016](https://pubmed.ncbi.nlm.nih.gov/27131351/)

### Where does this treatment go in a skincare routine for mature skin?

This treatment goes in your evening routine, applied after cleansing and before your moisturizer. Mature skin also needs specialized ingredients like retinoids or peptides to effectively target wrinkles and fine lines.

### Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol, but apply your retinol first and follow with this treatment to keep your routine gentle. This product is unlikely to cause irritation on your skin, though mature skin generally needs a product with retinoids or peptides to properly target wrinkles and fine lines.

### How often should I use this treatment?

Start by using this treatment once a week in your evening routine, and if your skin feels fine and you see good results, you can carefully use it more often. This type of product needs to include retinoids or peptides to effectively target wrinkles and fine lines on mature skin.

### Can this treatment clog pores, cause breakouts or purging for mature skin?

This treatment is unlikely to clog pores or cause breakouts on mature skin, as it contains salicylic acid and glycolic acid to help clear blemishes. However, because it lacks targeted anti-aging ingredients like retinoids or peptides to smooth out wrinkles and fine lines, mature skin needs a product formulated with retinoids or peptides.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/)

### Is this treatment fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum). Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — $53.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — $39.99 at Amazon
- [Drunk Elephant A-Passioni Retinol Cream](https://lovi.care/skincare/p/drunk-elephant/a-passioni-retinol-cream/for/mature-skin) — High fit — $76.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — $28.08 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — $17.00 at Amazon
- Moisturizer: [Obagi Hydrate Luxe Moisture-Rich Cream](https://lovi.care/skincare/p/obagi/hydrate-luxe/for/mature-skin) — Superior fit — $85.00 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Proylene Glycol, Glycerin, Cetearyl Alcohol, Cetearyl Glucoside, Glyceryl Stearate, Peg-100 Stearate, Silica, Dimethicone, Bht, Caprylic Capric Triglyceride, Pumpkin Seed Oil, Sodium Hydroxide, Sodium Polyacrylate, Sodium Stearoyl Glutamate, Zinc Gluconate, Capryloyl Glycine, Citric Acid, Parfum, Disodium Edta, Sodium Benzoate, Potassium Sorbate, Glyceryl Laurate, Monolaurin, Silybum Marianum Fruit Extract, Butylene Glycol, Silymarin, Dipotassium Glycyrrhizate, Tocopherol, Glycolic Acid, Salicylic Acid, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/avene/cleanance-comedomed/for/mature-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/avene/cleanance-comedomed/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/avene/cleanance-comedomed/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/avene/cleanance-comedomed/for/mature-skin
- France: https://lovi.care/skincare/fr/p/avene/cleanance-comedomed/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/avene/cleanance-comedomed/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/avene/cleanance-comedomed/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/avene/cleanance-comedomed/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/avene/cleanance-comedomed/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/avene/cleanance-comedomed/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/avene/cleanance-comedomed/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/avene/cleanance-comedomed/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/avene/cleanance-comedomed/for/mature-skin