ATOPALM MLE Cream for skin with dark spots

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Atopalm MLE Cream and Physiogel Intensive Cream both significantly increased stratum corneum hydration and improved lactic acid stinging test scores after 4 weeks in 60 patients with sensitive skin, while Atopalm MLE Cream also significantly lowered transepidermal water loss at 2 and 4 weeks.

  Dermatology and Therapy, 2016

• Multi-lamellar emulsion (MLE) as a vehicle for topical desonide increased epidermal retention and partially prevented steroid-induced skin barrier impairment without reducing the anti-inflammatory activity in murine models.

  Annals of Dermatology, 2013

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• Clay jojoba oil facial masks reduced total skin lesions by a mean of 54% after 6 weeks in 133 participants with acne-prone, lesioned skin and mild acne compared to baseline.

  Forschende Komplementarmedizin, 2012

• Topical application of jojoba wax reduced LPS-induced secretion of IL-6, IL-8, and TNFα by approximately 30% and increased the synthesis of pro-collagen III and hyaluronic acid compared to untreated skin in an ex-vivo human skin organ culture model.

  Frontiers in Pharmacology, 2024

• Topical jojoba oil application in male mice decreased exercise-induced pro-inflammatory gene expression (Il-1b and Il-6 in soleus, Il-1b in gastrocnemius) compared to untreated exercised mice.

  Biomolecules, 2025

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

Why other moisturizers fit skin with dark spots better

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2014

• Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers.

  International Journal of Medical Sciences, 2021

Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Cetearyl Alcohol, Pentaerythrityl Stearate Caprate Caprylate Adipate, Pentylene Glycol, Butyrospermum Parkii Butter Shea Butter, Propanediol, Sorbitan Stearate, Stearic Acid, Squalane, Polyglyceryl-5 Stearate, Jojoba Seed Oil, Glyceryl Stearate, Palmitoyl Palmitamide Mea, N-Decanoyl Serinol, Bis-Capryloyloxypalmitamido Isopropanol, Allantoin, Houttuynia Cordata Extract, Leucine, Lysine, Valine, Threonine, Phenylalanine, Hydrogenated Oil, Olea Europaea Oil Fruit Olive Oil Fruit, Tocopherol, Carbomer, Phytosterols, Phytosteryl Oleate, Carthamus Tinctorius Seed Oil, Vitis Vinifera Seed Oil Grape Seed Oil, Sodium Phytate, Arginine, Portulaca Oleracea Extract, Xanthan Gum, Helianthus Annuus Seed Oil Sunflower Seed Oil, Mistletoe Fruit Extract, Camellia Sinensis Seed Oil, Sodium Hyaluronate, Sunflower Decyl Esters Oil, Salvia Officinalis Oil, Beta-Glucan, Elettaria Cardamomum Seed Oil, Pogostemon Cablin Oil, Juniperus Mexicana Oil, Juniperus Communis Oil Fruit, Anthemis Nobilis Oil Flower, Butylene Glycol, 1,2-Hexanediol, Caprylic Capric Glycerides

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.