# APLB Glutathione Niacinamide Facial Cream for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [APLB](https://lovi.care/skincare/brands/aplb)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your normal skin, this cream effectively addresses redness and irritation with Centella Asiatica Extract and Madecassic Acid to calm inflammation and soothe your sensitive skin.
- Glycerin and Sodium Hyaluronate provide excellent humectant action, ensuring deep hydration and improving overall skin tone.
- The formulation is safe for your sensitive skin, containing no harsh ingredients and including soothing agents like Dipotassium Glycyrrhizate.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-facial-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-facial-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-facial-cream/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-facial-cream/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-facial-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-facial-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-facial-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-facial-cream/for/oily-acne-prone-skin): High

## Key ingredients

Glutathione, Niacinamide, Centella Asiatica Extract, Sodium Hyaluronate, Shea Butter

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Treatment with an asiaticoside-containing cream applied twice daily for 12 weeks significantly improved periorbital wrinkles in 65% of 27 female volunteers compared to a vehicle control cream. ([International Journal of Cosmetic Science, 2008](https://pubmed.ncbi.nlm.nih.gov/18452433/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))

## What reviewers say

Based on a very large amount of data, this lightweight, gel-like cream is highly favored by users with oily, combination, and sensitive skin for its fast absorption and soothing properties without leaving a sticky residue. Many appreciate its ability to calm redness and improve skin texture. However, users with dry skin often find it insufficiently moisturizing on its own, and brightening effects tend to be gradual or subtle.

- Liked: Affordable value (often mentioned)
- Liked: Fragrance-free (often mentioned)
- Liked: Lightweight & fast (often mentioned)
- Liked: Soothing & calming (often mentioned)
- Disliked: Not for dry skin (often mentioned)
- Disliked: No spatula (rarely noted)
- Disliked: Packaging concerns (rarely noted)
- Disliked: Slow brightening (rarely noted)

## How to apply

- Use this soothing AM and PM routine every day to keep your normal skin calm. Always remember to apply SPF in the morning after your moisturizer.
- Apply your moisturizer after your toner in the morning, and after your serum in the evening. This step locks in hydration and protects your skin.
- Gently press a small amount of the moisturizer evenly across your face. Avoid rubbing to keep your sensitive skin happy and calm.
- You can apply this gentle formula on dry or slightly damp skin for the best comfort. It works wonderfully on clean skin to soothe redness and irritation.
- Do a patch test before your very first use to check your skin's reaction. Avoid getting the product directly into your eyes .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes APLB Glutathione Niacinamide Facial Cream a great fit for sensitive skin?

APLB Glutathione Niacinamide Facial Cream is a great fit for sensitive skin because it helps calm redness and irritation using Centella Asiatica Extract and Madecassic Acid. Glycerin and Sodium Hyaluronate also provide deep hydration, while the gentle formula avoids harsh ingredients to keep your skin comfortable.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for sensitive skin?

Centella Asiatica Extract and Madecassic Acid make this cream a great fit for sensitive skin by helping calm inflammation and soothe redness. Glycerin and Sodium Hyaluronate further support this fit with deep hydration, while soothing agents like Dipotassium Glycyrrhizate help keep the formula gentle and safe.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/)

### What does Glutathione do for sensitive skin?

Glutathione helps calm sensitive skin by reducing oxidative stress and protecting against environmental irritation. It is unlikely to cause irritation and has a very safe profile when used on the skin.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/), [Indian Journal of Dermatology, Venereology and Leprology, 2016](https://pubmed.ncbi.nlm.nih.gov/27088927/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does it go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after your toner and before your moisturizer. It is a great fit for sensitive skin because it helps calm redness and irritation while deeply hydrating.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the retinol first, letting it absorb, and then following with this moisturizer to help calm potential irritation. Using a gentle moisturizing treatment alongside active ingredients like retinol helps support the skin barrier and keeps sensitive skin comfortable.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use it?

This cream is a great fit for your sensitive skin and is gentle enough for daily use in your evening routine. Using it regularly helps calm redness, soothe irritation, and keep your skin feeling deeply hydrated.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for sensitive skin?

This cream is unlikely to clog pores or cause breakouts on sensitive skin, as it has a very safe profile with soothing ingredients like Centella Asiatica Extract to calm irritation. Glycerin and Sodium Hyaluronate provide deep hydration without heavy oils that typically block pores.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use it around the eyes or on my body?

Yes, you can use this moisturizing treatment on the thin skin around your eyes and on your body because its soothing formula is safe for sensitive areas. The gentle ingredients help calm redness and provide deep hydration without causing irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [SKIN1004 Madagascar Centella Probio-Cica Enrich Cream](https://lovi.care/skincare/p/skin1004/madagascar-centella-probio-cica-enrich-cream/for/sensitive-skin) — Superior fit — $22.00 at Amazon
- [COSRX Advanced Snail 96 Mucin Power Essence](https://lovi.care/skincare/p/cosrx/advanced-snail-96-mucin-power-essence/for/sensitive-skin) — Superior fit — $15.88 at Amazon
- [COSRX Advanced Snail 92 All in One Cream](https://lovi.care/skincare/p/cosrx/advanced-snail-92-all-in-one-cream/for/sensitive-skin) — Superior fit — $16.50 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — $28.08 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/sensitive-skin) — Superior fit — $28.05 at Amazon
- Moisturizer with Sun Protection: [innisfree Daily Mild Sunscreen](https://lovi.care/skincare/p/innisfree/daily-mild-sunscreen/for/sensitive-skin) — Superior fit — $18.00 at Amazon

## Where to buy

- Amazon.com: $15.00 (https://www.amazon.com/dp/B0C2P3N623?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 3 Nov 2026.

## Ingredients

Water, Centella Asiatica Extract, Glycerin, Cetyl Ethylhexanoate, Butylene Glycol, Polyglyceryl-3 Methylglucose Distearate, Stearic Acid, Sodium Polyacryloyldimethyl Taurate, Silica, Sodium Hyaluronate, Glyceryl Stearate, Beeswax, Butyrospermum Parkii Butter Shea Butter, Macadamia Ternifolia Seed Oil, Hydrogenated Polydecene, Betaine, Trehalose, Adenosine, Citric Acid, Trideceth-10, Disodium Edta, Sodium Citrate, Caprylic Capric Triglyceride, Hydrogenated Lecithin, Cholesterol, Xanthan Gum, Nelumbo Nucifera Extract, Artemisia Annua Extract, Rice Extract, Saccharomyces Ferment, Solanum Melongena Fruit Extract, Melaleuca Alternifolia Tree Leaf Extract, Hydrolyzed Collagen, Squalane, Beta-Glucan, Ascorbic Acid, Dipropylene Glycol, Hippophae Rhamnoides Fruit Extract, Madecassic Acid, Asiaticoside, Asiatic Acid, Propanediol, Hydroxyacetophenone, 1,2-Hexanediol, Ethylhexylglycerin, Dipotassium Glycyrrhizate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/aplb/glutathione-niacinamide-facial-cream/for/sensitive-skin