# APLB Glutathione Niacinamide Ampoule Serum for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [APLB](https://lovi.care/skincare/brands/aplb)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your dry and sensitive skin, this serum effectively brightens and evens skin tone with niacinamide and ascorbic acid, while glycerin and sodium hyaluronate provide essential hydration to combat dryness and flakiness.
- The inclusion of squalane further supports your dry skin by offering emollient action, and panthenol aids in soothing and retaining moisture.
- The product is safe for your skin, as it contains no harsh or irritating ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-ampoule-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-ampoule-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-ampoule-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-ampoule-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-ampoule-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-ampoule-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/p/aplb/glutathione-niacinamide-ampoule-serum/for/oily-acne-prone-skin): High

## Key ingredients

Glutathione, Niacinamide, Centella Asiatica Extract, Sodium Hyaluronate, Squalane

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Based on a very large amount of data, users with sensitive, acne-prone, and combination skin frequently praise this serum for its lightweight, non-sticky hydration and ability to calm redness while gradually evening out skin tone. While it effectively delivers a "glass skin" glow and smooths texture, many users note that brightening hyperpigmentation is a slow process requiring consistent long-term use.

- Liked: Lightweight & absorbent (mostly mentioned)
- Liked: Brightens skin tone (often mentioned)
- Liked: Soothes sensitive skin (often mentioned)
- Liked: Hydrating & plumping (sometimes noted)
- Disliked: Slow visible results (sometimes noted)
- Disliked: Cheap packaging feel (rarely noted)
- Disliked: Insufficient for dryness (rarely noted)
- Disliked: Rare skin irritation (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes APLB Glutathione Niacinamide Ampoule Serum a great fit for dry sensitive skin?

APLB Glutathione Niacinamide Ampoule Serum is a great fit because it brightens your skin tone with niacinamide while glycerin and sodium hyaluronate hydrate dry and flaky areas. Squalane and panthenol help soften your skin and calm irritation while locking in moisture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which ingredients make this serum a good fit for dry sensitive skin?

This serum is a great fit for your dry sensitive skin because glycerin and sodium hyaluronate provide essential hydration to combat dryness and flakiness, while squalane softens the skin and panthenol helps soothe it. Niacinamide and ascorbic acid also work to brighten and even out your skin tone safely without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### What does Glutathione do for dry sensitive skin?

Glutathione helps improve moisture content and smoothness while reducing oxidative stress, making it a helpful option for dry sensitive skin. This ingredient may enhance hydration and elasticity while maintaining a gentle profile. To properly care for dry sensitive skin, a product of this type needs soothing and hydrating ingredients that support the skin barrier.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/)

### What does Niacinamide do for dry sensitive skin?

Niacinamide helps dry sensitive skin by calming irritation and keeping moisture locked in so your face feels soft and smooth. It works to build up your skin barrier and calm redness while being very gentle and unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [International Journal of Pharmaceutics, 2013](https://pubmed.ncbi.nlm.nih.gov/23220080/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This serum fits into the evening routine after your soothing toner and before your moisturizer. Putting treatments in the evening keeps things simple and helps avoid extra sensitivity around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to hydrate and calm dry sensitive skin, followed by your retinol. Because this product contains gentle soothing ingredients like centella asiatica and panthenol, it is unlikely to irritate your skin when paired with a retinoid.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### How often should I use this serum?

This serum is used in your evening routine, applying it then helps keep things simple and safe around sun exposure while caring for dry skin. It has a great safety profile for your skin with no harsh or irritating ingredients.

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to clog pores or cause breakouts for dry sensitive skin because it contains no harsh or irritating ingredients. Reviewers rarely report skin irritation, and the formula includes soothing ingredients that help keep skin calm and hydrated.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — $39.99 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin) — Superior fit — $53.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-sensitive-skin) — Superior fit — $16.75 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — $16.97 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — $28.05 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $15.00 (https://www.amazon.com/dp/B0C2P4LLXX?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Centella Asiatica Extract, Butylene Glycol, Propanediol, Glycerin, Diethoxyethyl Succinate, Panthenol, Sodium Hyaluronate, Allantoin, Sodium Polyacryloyldimethyl Taurate, Glyceryl Acrylate Acrylic Acid Copolymer, Nelumbo Nucifera Extract, Artemisia Annua Extract, Rice Extract, Saccharomyces Ferment, Solanum Melongena Fruit Extract, Melaleuca Alternifolia Tree Leaf Extract, Hydrolyzed Collagen, Squalane, Beta-Glucan, Ascorbic Acid, Dipropylene Glycol, Hippophae Rhamnoides Fruit Extract, Adenosine, Madecassic Acid, Asiaticoside, Asiatic Acid, Caprylic Capric Triglyceride, Hydrogenated Lecithin, Glyceryl Stearate, Cholesterol, Styrene Acrylates Copolymer, Cellulose Gum, Xanthan Gum, Inulin, Cellulose, Glucose, Fructose, Citric Acid, Disodium Edta, Hydroxyacetophenone, 1,2-Hexanediol, Ethylhexylglycerin, Dipotassium Glycyrrhizate, Sodium Citrate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/aplb/glutathione-niacinamide-ampoule-serum/for/dry-sensitive-skin