# Anua Heartleaf 80 Moisture Soothing Ampoule for oily skin

**Lovi Fit: High fit for oily skin.**
Oily Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Anua](https://lovi.care/skincare/brands/anua)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with oily skin: shine, enlarged pores, blackheads, and blemishes. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for oily skin.

## Why this fit

- Excellent suitability for your oily skin is provided by Houttuynia Cordata Extract and Glycerin, which offer anti-inflammatory and humectant actions respectively, perfectly addressing your skin's needs for oily shine.
- The formulation also includes Allantoin and Panthenol, which further soothe and hydrate your skin, enhancing overall comfort and skin health.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin): High (this page)
- [Dry skin](https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-acne-prone-skin): Superior

## Key ingredients

Heartleaf Extract, Hyaluronic Acid, Glycerin, Allantoin, Panthenol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream. ([Clinical, Cosmetic and Investigational Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27013898/))
- Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution. ([Molecules, 2019](https://pubmed.ncbi.nlm.nih.gov/31238562/))
- Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration. ([Gels, 2023](https://pubmed.ncbi.nlm.nih.gov/37754433/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))

## What reviewers say

Based on a very large amount of data, this ampoule is widely praised by users with sensitive and acne-prone skin for its ability to rapidly soothe redness and provide deep hydration without clogging pores. While most users achieve a "glass skin" glow and reduced inflammation, a minority experience a tacky finish or find it ineffective for severe breakouts.

- Liked: Soothing redness (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Acne care (sometimes noted)
- Liked: Lightweight texture (sometimes noted)
- Disliked: Small quantity (sometimes noted)
- Disliked: Sticky finish (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Lack of results (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine every day to keep your face fresh.
- Apply this moisturizer after cleansing and toning, but right before your SPF in the morning.
- Gently press a small amount into your skin and let it absorb fully.
- Apply on clean, slightly dry skin to help control that oily shine.
- Avoid the eye area and do a quick patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Anua Heartleaf 80 Ampoule a great fit for oily skin?

Anua Heartleaf 80 Moisture Soothing Ampoule is a great fit for oily skin because heartleaf extract calms redness and glycerin draws in lightweight moisture without adding heavy oil. Allantoin and panthenol also help soothe your skin and keep it comfortable, while the formula has a very safe profile that is unlikely to cause irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Which ingredients make this serum a good fit for oily skin?

Heartleaf extract and glycerin make this serum a great fit by calming your skin and managing oily shine without feeling heavy. Allantoin and panthenol also help soothe and keep your skin comfortable.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does Heartleaf Extract do for oily skin?

Heartleaf Extract helps calm oily skin by lowering inflammation and fighting bacteria that can clog pores. It may also protect skin from daily stress and irritation while keeping it clear and balanced.
Sources: [Bioscience, Biotechnology, and Biochemistry, 2016](https://pubmed.ncbi.nlm.nih.gov/27023331/), [Applied Biochemistry and Biotechnology, 2023](https://pubmed.ncbi.nlm.nih.gov/36495375/)

### What does Hyaluronic Acid do for oily skin?

Hyaluronic acid helps oily skin by reducing extra oil and sebum production without causing irritation. Clinical studies show it successfully balances oil levels while keeping the skin comfortable.
Sources: [The Journal of Investigative Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28163068/)

### Where does this serum go in a skincare routine for oily skin?

This treatment goes in your evening routine after cleansing and toning, and before your moisturizer. Putting it in the evening keeps things simple and adds extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying the serum first to keep your skin calm and hydrated, followed by your retinol product. Using a soothing and hydrating layer helps reduce the redness and irritation that can sometimes happen when using retinol on your skin.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### How often should I use this serum?

You can use this treatment in your evening routine for simplicity and extra safety around sun exposure. Its gentle formula is unlikely to cause irritation and supports everyday use.

### Can this serum clog pores, cause breakouts or purging for oily skin?

This serum is unlikely to clog pores or cause breakouts for oily skin, as it has a very safe formula with soothing ingredients and a low chance of causing spots. Panthenol and glycerin help keep the skin calm and hydrated without heavy oils.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use this serum around the eyes or on my body?

You can use this serum around the eyes and on the body because it has a very safe formula with soothing ingredients like allantoin and panthenol that are gentle enough for thinner areas of skin. It is unlikely to cause irritation and helps keep skin calm and hydrated anywhere you apply it.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily skin

- [Elizavecca Witch Piggy Hell Pore Control Hyaluronic Acid 97%](https://lovi.care/skincare/p/elizavecca/witch-piggy-hell-pore-control-hyaluronic-acid-97/for/oily-skin) — High fit — $8.40 at Amazon
- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/oily-skin) — High fit — $125.00 at Amazon
- [Torriden DIVE-IN Low Molecular Hyaluronic Acid Serum](https://lovi.care/skincare/p/torriden/dive-in-low-molecular-hyaluronic-acid-serum/for/oily-skin) — High fit — $22.25 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/oily-skin) — Superior fit — $15.60 at Amazon
- SPF: [CeraVe AM Facial Moisturizing Lotion](https://lovi.care/skincare/p/cerave/am-facial-moisturizing-lotion-spf-30/for/oily-skin) — Superior fit — $14.97 at Amazon

## Where to buy

- Amazon.com: $22.00 (https://www.amazon.com/dp/B08CMVXQ9W?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Houttuynia Cordata Extract, Glycerin, Butylene Glycol, 1,2-Hexanediol, Hyaluronic Acid, Betaine, Allantoin, Panthenol, Ethylhexylglycerin, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin
- Ireland: https://lovi.care/skincare/ie/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin
- Germany: https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin
- France: https://lovi.care/skincare/fr/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin
- Italy: https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin
- Netherlands: https://lovi.care/skincare/nl/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin
- Spain: https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin
- Canada: https://lovi.care/skincare/ca/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin
- Australia: https://lovi.care/skincare/au/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin
- Singapore: https://lovi.care/skincare/sg/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin