# Aestura A-Cica 365 Blemish Calming Serum for dry sensitive skin

**Lovi Fit: High fit for dry sensitive skin.**
Dry Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Aestura](https://lovi.care/skincare/brands/aestura)
Category: [Serums and treatments](https://lovi.care/skincare/best/serums)

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for dry sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your dry and sensitive skin as glycerin and squalane provide essential humectant and emollient actions, while madecassoside and beta-glucan offer excellent calming and soothing benefits.
- The formula also includes niacinamide, which can help improve skin barrier function and reduce redness, further supporting your skin's needs.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin): High (this page)
- [Oily acne-prone skin](https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica, Niacinamide, Madecassoside, Beta-Glucan, Squalene

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- A single use of an alpha-tocopherol-enriched rinse-off product strongly increases alpha-tocopherol levels in skin barrier lipids maintained for at least 24 hours and significantly inhibits squalene photooxidation in human volunteers compared to a control product. ([Skin Pharmacology and Physiology, 2005](https://pubmed.ncbi.nlm.nih.gov/15608499/))
- The investigated actives incorporated into alkyl polyglucoside emulsifier-stabilized creams showed no skin irritation and provided increased skin hydration and reduced transepidermal water loss in 76 healthy volunteers. ([Vojnosanitetski Pregled, 2016](https://pubmed.ncbi.nlm.nih.gov/29328637/))
- Topical treatment with a mixed RetinSphere - vitamin E formulation significantly decreased lipid peroxidation levels and oxidized squalene percentage, reduced interleukin-1α concentration in lesional areas, and led to clinical improvement in 18 patients with mild comedonal acne. ([Journal of the European Academy of Dermatology and Venereology, 2014](https://pubmed.ncbi.nlm.nih.gov/24628899/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised by users with sensitive and acne-prone skin for its ability to rapidly soothe redness and repair the skin barrier without causing irritation. The lightweight, non-sticky formula is effective for calming inflammation and improving texture. However, many users find the small bottle size and high price point to be significant drawbacks.

- Disliked: Expensive for size (mostly mentioned)
- Liked: Calms redness fast (often mentioned)
- Liked: Gentle, non-irritating (often mentioned)
- Liked: Lightweight, non-sticky (often mentioned)
- Liked: Hydrating for oily (sometimes noted)
- Liked: Improves texture (sometimes noted)
- Disliked: Not enough for dry (sometimes noted)
- Disliked: Heavy for summer (rarely noted)
- Disliked: Slightly tacky (rarely noted)

## How to apply

- Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
- Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
- Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
- Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
- Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Aestura A-Cica 365 Blemish Calming Serum a great fit for dry sensitive skin?

This serum is a great fit because glycerin and squalane help keep your skin soft and hydrated, while madecassoside and beta-glucan calm and soothe easily irritated areas. Niacinamide further supports your skin by strengthening its barrier and reducing redness, all with an excellent safety profile that is unlikely to cause irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for dry sensitive skin?

Glycerin and squalane help keep dry skin soft by holding in moisture, while centella asiatica, madecassoside, and beta-glucan calm sensitive skin and reduce redness. Niacinamide further supports your skin by helping to strengthen the skin barrier.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Centella Asiatica do for dry sensitive skin?

Centella asiatica helps calm dry sensitive skin by improving moisture, reducing water loss, and soothing irritation. Using this ingredient helps repair the skin barrier and keeps the skin feeling soft and comfortable.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40682399/)

### What does Niacinamide do for dry sensitive skin?

Niacinamide helps dry sensitive skin by calming irritation and keeping moisture locked in so your face feels soft and smooth. It works to build up your skin barrier and calm redness while being very gentle and unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [International Journal of Pharmaceutics, 2013](https://pubmed.ncbi.nlm.nih.gov/23220080/)

### Where does this serum go in a skincare routine for dry sensitive skin?

This serum goes in your evening routine after your toner and before your moisturizer. Putting treatments in the evening helps keep things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying it before your retinol step to help calm and hydrate your skin. The soothing ingredients in this formula are very unlikely to cause irritation when paired with active treatments.

### How often should I use this serum?

You can use this treatment in your evening routine, applying it after your toner and before your moisturizer. It is gentle enough for daily use and helps keep your skin calm and hydrated without irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to clog pores or cause breakouts for your dry sensitive skin. Its gentle ingredients and excellent safety profile mean it has no harsh additives that typically trigger irritation.

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for dry sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/p/skinceuticals/c-e-ferulic/for/dry-sensitive-skin) — Superior fit — $39.99 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-sensitive-skin) — Superior fit — $53.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-sensitive-skin) — Superior fit — $16.75 at Amazon

## Pairs well with

- Cleanser: [CeraVe Hydrating Cleanser](https://lovi.care/skincare/p/cerave/hydrating-facial-cleanser/for/dry-sensitive-skin) — Superior fit — $16.97 at Amazon
- Soothing Toner: [Clarins Toning Lotion with Camomile](https://lovi.care/skincare/p/clarins/soothing-toning-lotion/for/dry-sensitive-skin) — Superior fit — $28.05 at Amazon
- Moisturizer with Sun Protection: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/dry-sensitive-skin) — Superior fit — $18.99 at Amazon

## Where to buy

- Amazon.com: $38.00 (https://www.amazon.com/dp/B0GGTKRY3G?tag=lovi-care-web-product-20&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Dipropylene Glycol, Betaine, Niacinamide, 1,2-Hexanediol, Alcohol Denat, Squalene, Diethoxyethyl Succinate, Polyglyceryl-10 Stearate, Sucrose Stearate, Polymethyl Methacrylate, Polyglyceryl-10 Laurate, Phytosterols, Caprylyl Methicone, Carbomer, Hydrogenated Lecithin, Hydrogenated Phosphatidylcholine, Tromethamine, Ethylhexylglycerin, Xanthan Gum, Propanediol, Cellulose Gum, Disodium Edta, Madecassoside, Beta-Glucan, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin
- Germany: https://lovi.care/skincare/de/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin
- France: https://lovi.care/skincare/fr/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin
- Italy: https://lovi.care/skincare/it/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin
- Spain: https://lovi.care/skincare/es/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin
- Australia: https://lovi.care/skincare/au/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/aestura/a-cica-365-blemish-calming-serum/for/dry-sensitive-skin