# Advanced Clinicals HYALURONIC SERUM for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the United States.

Brand: [Advanced Clinicals](https://lovi.care/skincare/brands/advanced-clinicals)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate moisturizing for your combination skin, as hyaluronic acid and glycerin provide hydration, while Camellia Sinensis Leaf Extract offers antioxidant benefits.
- While beneficial for general hydration, the formula does not specifically target your acne, blemishes, and breakouts.
- The product is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/p/advanced-clinicals/hyaluronic-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/p/advanced-clinicals/hyaluronic-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/p/advanced-clinicals/hyaluronic-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/p/advanced-clinicals/hyaluronic-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/p/advanced-clinicals/hyaluronic-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/p/advanced-clinicals/hyaluronic-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/p/advanced-clinicals/hyaluronic-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/p/advanced-clinicals/hyaluronic-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Hyaluronic Acid, Glycerin, Aloe Barbadensis Leaf Juice

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo. ([Experimental Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/18631247/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))

## Why other moisturizers fit acne-prone skin better

- Gluconolactone 14% solution significantly improved mild to moderate acne by reducing inflamed and non-inflamed lesions similarly to 5% benzoyl peroxide, but with fewer side-effects in 150 patients. ([The Australasian Journal of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1303072/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))

## What reviewers say

This serum is highly effective for providing instant and deep hydration, improving skin texture, and reducing the appearance of fine lines, making it a popular choice for dry, dehydrated, and aging skin types. Users frequently experience a plumper complexion and diminished fine lines. Some users note a slightly sticky finish or a strong fragrance.

- Liked: Deeply hydrating (mostly mentioned)
- Liked: Great value (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Liked: Absorbs quickly (sometimes noted)
- Disliked: Noticeable fragrance (sometimes noted)
- Disliked: Slightly sticky finish (sometimes noted)
- Disliked: Potential ingredient concerns (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Advanced Clinicals Hyaluronic Serum work for acne-prone skin?

Advanced Clinicals Hyaluronic Serum works for your acne-prone skin by offering moderate hydration through ingredients like hyaluronic acid and glycerin, while green tea extract provides antioxidant benefits. However, the formula does not specifically target blemishes and breakouts. A product of this type needs acne-fighting ingredients like Niacinamide, peptides, or Centella Asiatica, alongside lightweight hydration that prevents excess oiliness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Experimental Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/18631247/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum works for acne-prone skin because hyaluronic acid and glycerin provide hydration, while green tea extract offers antioxidant benefits with no risk of irritation. However, a product of this type needs acne-fighting ingredients like niacinamide or Centella Asiatica to truly target breakouts and care for this skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Experimental Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/18631247/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### What does Glycerin do for acne-prone skin?

Glycerin helps keep acne-prone skin hydrated and calm without clogging pores or feeling heavy. It supports the skin barrier so it stays soft and smooth while handling everyday treatments.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [International Journal of Toxicology, 2019](https://pubmed.ncbi.nlm.nih.gov/31840548/)

### Where does this serum go in a skincare routine for acne-prone skin?

Apply this treatment serum in the evening after cleansing and toning, and follow it with a moisturizer. Putting treatments in the evening keeps the routine simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first to give your skin a boost of hydration, followed by your retinol treatment. This product helps keep your skin comfortable during treatment, though acne-prone skin often does better with a product that also targets breakouts and blemishes.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### How often should I use this serum?

You can use this serum in the evening as part of your routine. Daily application helps keep your skin hydrated and smooth, though acne-prone skin also needs targeted ingredients that actively clear breakouts.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to cause breakouts or purging for acne-prone skin, as it contains no harsh ingredients that typically trigger irritation. However, because the formula does not specifically target blemishes, acne-prone skin needs products with ingredients that clear pores and calm active breakouts.

### Can I use this serum around the eyes or on my body?

You can use this serum safely around the eyes and on your body because the formula is gentle and well-tolerated. However, because the skin around the eyes and on the body can be very thin, a moisturizing treatment of this type needs specific barrier-strengthening ingredients and deep hydration to properly care for these delicate areas.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (limonene, geraniol, hexyl cinnamal, and linalool).

## Alternatives for acne-prone skin

- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/acne-prone-skin) — High fit — $24.40 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/acne-prone-skin) — High fit — $19.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — $15.97 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — $15.60 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/p/d-alba/piedmont-waterfull-mild-sunscreen/for/acne-prone-skin) — Superior fit — $15.99 at Amazon

## Where to buy

No store in United States has a checked price for this product, so the page shows none.

## Ingredients

Water, Ethoxydiglycol, Glycerin, Pyrus Malus Fruit Extract, Peg-12 Dimethicone, Hyaluronic Acid, Chondrus Crispus Extract, Camellia Sinensis Leaf Extract, Aloe Barbadensis Leaf Juice, Sodium Carboxymethyl Beta-Glucan, Epilobium Angustifolium Stem Extract Flower Leaf, Tocopheryl Acetate, Xanthan Gum, Phenoxyethanol, Maltodextrin, Tetrasodium Glutamate Diacetate, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol, Citric Acid, Limonene, Geraniol, Hexyl Cinnamal, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin (this page)
- United Kingdom: https://lovi.care/skincare/uk/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/advanced-clinicals/hyaluronic-serum/for/acne-prone-skin