# ZO Skin Health Firming Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/nl/p/zo-skin-health/firming-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [ZO Skin Health](https://lovi.care/skincare/nl/brands/zo-skin-health)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Offers moderate firming and plumping benefits for your normal skin, with Caprooyl Tetrapeptide-3 and Leontopodium Alpinum Meristem Cell Culture supporting collagen synthesis and ECM production.
- While Glycerin and Propanediol provide essential hydration, the formula's primary focus is not on directly addressing your main concern of wrinkles and fine lines.
- The product is safe for your normal skin, as it contains soothing ingredients like Glycerin and Leontopodium Alpinum Meristem Cell Culture, and lacks harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/zo-skin-health/firming-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/zo-skin-health/firming-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/nl/p/zo-skin-health/firming-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/zo-skin-health/firming-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/zo-skin-health/firming-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/zo-skin-health/firming-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/zo-skin-health/firming-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/zo-skin-health/firming-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/zo-skin-health/firming-serum/for/oily-acne-prone-skin): High

## Key ingredients

Retinyl Palmitate, Sodium Dna, Caprooyl Tetrapeptide-3, Leontopodium Alpinum Meristem Cell Culture, Tocopheryl Acetate

## What the research says

- Leontopodium alpinum callus culture extract improved anti-periorbital wrinkles, skin elasticity, dermal density, skin thickness, antioxidant activity, and moisturizing activity while suppressing inflammation and wrinkling compared to placebo and in response to UVB treatment. ([Genes, 2020](https://pubmed.ncbi.nlm.nih.gov/32098197/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- A concentrated ethanol extract of Edelweiss callus culture (ECC55) protected primary human keratinocytes and endotheliocytes against various inflammatory and oxidative stimuli by inhibiting chemokine release, restoring sirtuin-inhibited cellular markers, and suppressing inflammation-related gene expression. ([Mediators of Inflammation, 2012](https://pubmed.ncbi.nlm.nih.gov/23093820/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- Leontopodium alpinum callus culture extract at 10-15 mg/mL promoted COL-I production and inhibited MMP-1, OPN3, ROS, and calcium influx in a blue-light-induced human foreskin fibroblast damage model, indicating an anti-blue-light-damage effect through the OPN3-calcium pathway. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/36903418/))
- Leontopodic acid A effectively boosted COI-1 expression, hindered MMP-1 expression, curbed ROS and Ca2+ endocytosis, and reduced OPN3 expression in human foreskin fibroblasts to protect against blue light damage. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37959738/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))

## What reviewers say

This product is highly praised for its ability to visibly lift, tighten, and improve the structural integrity of aging skin. Users across various skin types report that the lightweight, hydrating formula effectively reduces the appearance of sagging jowls and fine lines, resulting in a more defined and youthful facial contour.

- Liked: Visible firming (mostly mentioned)
- Liked: Lightweight texture (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Improves texture (sometimes noted)
- Disliked: Minimal results (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes ZO Skin Health Firming Serum a great fit for mature skin?

ZO Skin Health Firming Serum is a great fit for mature skin because it contains Caprooyl Tetrapeptide-3 and Leontopodium Alpinum Meristem Cell Culture, which help support collagen and keep skin looking firm and plump. It also brings essential hydration to keep your skin feeling soft and smooth while remaining gentle.
Sources: [Genes, 2020](https://pubmed.ncbi.nlm.nih.gov/32098197/), [International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a good fit for mature skin because it contains Caprooyl Tetrapeptide-3 and Leontopodium Alpinum Meristem Cell Culture, which help support collagen and keep skin firm and plump. It also includes Glycerin and Propanediol to provide essential hydration.
Sources: [Genes, 2020](https://pubmed.ncbi.nlm.nih.gov/32098197/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Retinyl Palmitate do for mature skin?

Retinyl palmitate helps smooth out fine lines and wrinkles on mature skin while improving overall firmness, texture, and dryness. It may also help protect against sun-induced aging by supporting skin structure and reducing collagen breakdown.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2011](https://pubmed.ncbi.nlm.nih.gov/21411295/), [Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23438139/)

### What does Sodium DNA do for mature skin?

Sodium DNA helps smooth out fine lines, improve elasticity, and restore a firm feel for mature skin. Clinical reviews show it is effective at reducing wrinkles and improving overall skin texture with mild side effects.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39645667/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in your evening routine after cleansing and before moisturizing, following Lovi's suggested schedule for treatments with active ingredients. Using treatments in the evening helps provide extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with a retinol, applying this treatment first in your evening routine and following with your retinol product. Because both ingredients help firm and smooth the skin, using them together may occasionally cause dryness, so introduce them slowly to see how your skin feels.
Sources: [Genes, 2020](https://pubmed.ncbi.nlm.nih.gov/32098197/)

### How often should I use this serum?

Apply this serum in your evening routine, using it after cleansing and before moisturizing. Retinoids and peptides like the ones in this formula help rejuvenate mature skin safely and effectively when used consistently at night.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Genes, 2020](https://pubmed.ncbi.nlm.nih.gov/32098197/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it contains soothing ingredients and lacks harsh substances.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum and limonene).

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €160.00 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €35.50 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/nl/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — €419.00 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/nl/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €48.84 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Propanediol, Dipropylene Glycol, Sodium Dna, Leontopodium Alpinum Meristem Cell Culture, Marrubium Vulgare Meristem Cell Culture, Melilotus Officinalis Extract, Tocopheryl Acetate, Retinyl Palmitate, Caprooyl Tetrapeptide-3, Lecithin, Dextran, Hydroxypropyl Methylcellulose, Carbomer, Aminomethyl Propanol, Cellulose, Polysorbate 20, Caprylyl Glycol, Lactose, Ethylhexylglycerin, Hexylene Glycol, Disodium Edta, Citric Acid, Phenoxyethanol, Parfum, Ultramarines, Ext, Violet 2, Limonene
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/zo-skin-health/firming-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/zo-skin-health/firming-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/zo-skin-health/firming-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/zo-skin-health/firming-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/zo-skin-health/firming-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/zo-skin-health/firming-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/zo-skin-health/firming-serum/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/zo-skin-health/firming-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/zo-skin-health/firming-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/zo-skin-health/firming-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/zo-skin-health/firming-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/zo-skin-health/firming-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/zo-skin-health/firming-serum/for/mature-skin