# VT Cosmetics PDRN Essence 100 for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [VT Cosmetics](https://lovi.care/skincare/nl/brands/vt-cosmetics)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- Offers moderate skin regeneration for your combination skin, as PDRN Polydeoxyribonucleotide and Sodium Hyaluronate promote skin repair and hydration, while Niacinamide helps regulate oil production.
- General skincare benefits like hydration from Sodium Hyaluronate and soothing from Allantoin support your acne and blemishes, though targeted ingredients for direct concern resolution are absent.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like Sodium Hyaluronate and Panthenol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/oily-acne-prone-skin): High

## Key ingredients

Pdrn Polydeoxyribonucleotide, Sodium Hyaluronate, Niacinamide, Adenosine

## What the research says

- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## Why other serums fit acne-prone skin better

- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Based on a very large amount of data, users with dry, sensitive, and combination skin highly praise this essence for its ability to deliver a glass skin finish and deep hydration without irritation. It is widely celebrated for restoring compromised barriers and plumping fine lines. A minority of users with oily skin find the texture too heavy or tacky.

- Liked: Hydration and glow (mostly mentioned)
- Liked: Soothing and repair (often mentioned)
- Liked: Fragrance-free (sometimes noted)
- Liked: Good texture (sometimes noted)
- Disliked: Sticky finish (sometimes noted)
- Liked: Nice packaging (rarely noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Expensive price (rarely noted)
- Disliked: Pump design (rarely noted)
- Disliked: Texture issues (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does VT PDRN Essence 100 work for acne-prone skin?

VT PDRN Essence 100 works moderately well for acne-prone skin, providing gentle hydration and soothing care through ingredients like Sodium Hyaluronate and Allantoin. While it helps calm and support your skin safely without causing irritation, it lacks targeted ingredients for direct breakout resolution. Acne-prone skin typically needs products with effective ingredients like niacinamide and propolis that provide excellent skincare benefits for acne and breakouts while controlling oiliness.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/)

### Which ingredients make this treatment a good fit for acne-prone skin?

Pdrn Polydeoxyribonucleotide and Sodium Hyaluronate help repair your skin and keep it hydrated, while Niacinamide helps control oil. This treatment for acne-prone skin needs ingredients like propolis or zinc pca to target breakouts directly while maintaining moisture and balance without causing excess oiliness.
Sources: [Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### What does PDRN do for acne-prone skin?

PDRN helps calm acne-prone skin by supporting barrier recovery and improving overall skin condition. It is unlikely to clog pores and may assist with soothing irritated areas.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/), [Pharmaceutics, 2025](https://pubmed.ncbi.nlm.nih.gov/40871045/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this treatment go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps it simple and safe for your skin. It is very unlikely to cause irritation because it lacks harsh ingredients and includes soothing components. Acne-prone skin works best with a treatment that includes targeted blemish-fighting ingredients and oil-balancing components.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this treatment with retinol, and in what order?

You can use this treatment with retinol by applying the treatment first and then following with your retinol. This product is unlikely to cause irritation because it contains soothing components like Sodium Hyaluronate and Panthenol.

### How often should I use this treatment?

You can use this treatment in your evening routine, as this type of product is typically applied at night for simplicity and extra safety around sun exposure. For acne-prone skin, a product of this type needs targeted ingredients for direct concern resolution, along with soothing components and oil-regulating ingredients.

### Can this treatment clog pores, cause breakouts or purging for acne-prone skin?

This treatment is unlikely to cause breakouts because it has a very safe formula with soothing ingredients like panthenol and sodium hyaluronate, though a few reviewers have reported breakouts. Acne-prone skin needs products with targeted active ingredients to directly clear blemishes and regulate oil production.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — €10.20 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €35.80 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €160.00 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/nl/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €19.20 at Amazon

## Where to buy

- Amazon.nl: €29.99 (https://www.amazon.nl/dp/B0CRKPZ9PQ?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Notino: €39.50 (https://www.notino.nl/vt-cosmetics/pdrn-100-essence-herstellende-huidessence-met-hydraterende-werking/p-16345771/)
- Lookfantastic: €40.00 (https://www.lookfantastic.nl/p/vt-cosmetics-pdrn-essence-100/17620559/)
Prices checked 14 Oct – 5 Nov 2026.

## Ingredients

Water, Pdrn Polydeoxyribonucleotide, Sodium Hyaluronate, Glycerin, Butylene Glycol, Niacinamide, Panthenol, Allantoin, Adenosine, Betaine, Phenoxyethanol, Ethylhexylglycerin, Carbomer, Triethanolamine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin (this page)
- Spain: https://lovi.care/skincare/es/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/vt-cosmetics/pdrn-essence-100/for/acne-prone-skin