Topicals Faded Brightening & Clearing Gel for skin with dark spots

How to apply

Questions and answers

What the research says

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations.

  Heliyon, 2023

• Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2014

• Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.

  Molecules, 2023

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability.

  Journal of Cosmetic Science, 2020

• Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants.

  Journal of Cosmetic Dermatology, 2025

• Polyvinyl pyrrolidone-K90/Eudragit RL100 dissolving microneedle patches loaded with alpha-arbutin and resveratrol enhanced intradermal delivery by approximately 2.6 times compared to cream and slightly decreased the melanin index in human participants without causing skin irritation.

  Biomaterials Science, 2023

• Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne.

  Pharmaceutics, 2021

• Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo.

  Dermatology and Therapy, 2024

• Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks.

  Journal of the European Academy of Dermatology and Venereology, 2023

• A topical formulation containing kojic acid, emblica extract, and glycolic acid demonstrated efficacy parity compared with hydroquinone 4% in multiethnic participants with mild to moderate facial dyschromia.

  Cutis, 2010

• A nanoemulsion containing 1 mg/mL kojic dipalmitate and 5% rosehip oil demonstrated high incorporation efficiency, suitable physicochemical stability, antioxidant and depigmenting efficacy close to 1 mM ascorbic acid, and no cytotoxicity at concentrations from 0.06% to 1% in vitro.

  Pharmaceutics, 2023

• Topical application of iron chelators kojic acid and deferiprone significantly accelerated wound healing in rats compared to control groups, with deferiprone showing superior efficacy due to higher antioxidant and iron chelation abilities.

  International Wound Journal, 2013

Ingredients

Water, Caprylic Capric Triglyceride, Glycerin, Niacinamide, Glyceryl Stearate, Tranexamic Acid, Butyrospermum Parkii Butter Shea Butter, Jojoba Seed Oil, Alpha-Arbutin, Behenyl Alcohol, Kojic Acid Dipalmitate, Glutathione, Curcuma Longa Root Extract, Ethylene Brassylate, Dimethylmethoxy Chromanyl Palmitate, Azelaic Acid, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Melatonin, Phytic Acid, Squalane, Allantoin, Centella Asiatica Leaf Extract, Tocopherol, Arginine, Lecithin, Glycine Soja Soybean Sterols, Cetyl Palmitate, Ethylhexylglycerin, Sclerotium Gum, Zinc Ricinoleate, Cetearyl Alcohol, Sodium Lauroyl Sarcosinate, Tetrahydroxypropyl Ethylenediamine, Trisodium Ethylenediamine Disuccinate, Ceteareth-12, Ceteareth-20, Phenoxyethanol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.