# Timeless Coenzyme Q10 Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/timeless/coenzyme-q10-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Timeless](https://lovi.care/skincare/nl/brands/timeless)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers excellent anti-aging benefits for your combination skin, as Matrixyl 3000 and Ubiquinone work to firm and minimize fine lines, while Glycerin and Sodium Hyaluronate provide essential hydration.
- While the formula offers antioxidant support with Vitamin E, it lacks targeted ingredients for active acne treatment, which is your main concern.
- The product is safe for your combination skin, with Aloe Barbadensis providing soothing benefits and no harsh ingredients present.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/timeless/coenzyme-q10-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/timeless/coenzyme-q10-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/timeless/coenzyme-q10-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/timeless/coenzyme-q10-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/timeless/coenzyme-q10-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/nl/p/timeless/coenzyme-q10-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/timeless/coenzyme-q10-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/timeless/coenzyme-q10-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/timeless/coenzyme-q10-serum/for/oily-acne-prone-skin): High

## Key ingredients

Ubiquinone, Matrixyl 3000, Sodium Hyaluronate, Aloe Barbadensis, Vitamin E

## What the research says

- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of CoQ10 improves mitochondrial function in aging skin in vivo, combating cellular signs of aging caused by an age-dependent shift to a functionally anaerobic energy metabolism. ([BioFactors, 2008](https://pubmed.ncbi.nlm.nih.gov/19096122/))
- Encapsulating coenzyme Q10 in lipid nanoparticles for topical use improves skin compatibility, protects against degradation, increases skin penetration, and provides controlled release to counteract aging effects. ([Colloids and Surfaces. B, Biointerfaces, 2023](https://pubmed.ncbi.nlm.nih.gov/37574615/))
- Review of topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles highlights their improved bioavailability, chemical stability, skin absorption, and photoprotective effects. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34206935/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Topical aloe vera gel significantly accelerated split-thickness skin graft donor-site healing compared to placebo in 12 patients, but showed no significant difference in pain relief. ([Plastic and Reconstructive Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29649056/))
- Topical application of Aloe vera cream reduced postoperative pain at rest and during defecation, accelerated wound healing at two weeks, and decreased analgesic requirements in patients after open hemorrhoidectomy compared to placebo. ([Journal of Alternative and Complementary Medicine, 2010](https://pubmed.ncbi.nlm.nih.gov/20569031/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))

## What reviewers say

Based on a very large amount of data, this serum is highly praised for its lightweight, fast-absorbing, and non-greasy formula that effectively hydrates and smooths skin texture, particularly favored by those with mature, combination, or sensitive skin. Users frequently report improvements in skin texture and hydration, leading to a firmer, more youthful appearance without irritation. Some users noted limited dramatic results or concerns about the product size and potential dryness.

- Liked: Lightweight, fast-absorbing (mostly mentioned)
- Liked: Effective hydration (often mentioned)
- Liked: Gentle, non-irritating (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: Limited visible results (sometimes noted)
- Disliked: Potential dryness (rarely noted)
- Disliked: Small bottle size (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Timeless Coenzyme Q10 Serum a great fit for acne-prone skin?

Timeless Coenzyme Q10 Serum is a great fit because it is safe for acne-prone skin and provides soothing benefits from aloe vera without any harsh ingredients. It also helps firm and smooth fine lines with Matrixyl 3000 and Coenzyme Q10, while glycerin and sodium hyaluronate keep your skin hydrated.
Sources: [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which ingredients make this serum a good fit for acne-prone skin?

Ubiquinone and Matrixyl 3000 help firm and smooth fine lines, while glycerin and sodium hyaluronate provide essential hydration to keep skin soft. Aloe barbadensis helps calm the skin, and vitamin E offers antioxidant support.
Sources: [Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Coenzyme Q10 do for acne-prone skin?

Coenzyme Q10 helps protect acne-prone skin by reducing free radicals and boosting antioxidant levels. It is unlikely to cause irritation and may support overall skin health when used as part of your routine.
Sources: [BioFactors, 2015](https://pubmed.ncbi.nlm.nih.gov/26648450/), [The Journal of Clinical and Aesthetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39148958/)

### What does Matrixyl 3000 do for acne-prone skin?

Matrixyl 3000 helps smooth fine lines and supports firmness by boosting collagen in the skin, but it does not directly treat acne or breakouts. Because acne-prone skin still needs anti-aging care, this ingredient works best in a lightweight, oil-free formula that will not clog pores or feel heavy.
Sources: [International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/), [International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment serum goes in your evening routine, applied after cleansing and before moisturizing. Putting treatments in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use it with retinol, and in what order?

Yes, you can use this treatment with retinol by applying the treatment first and following it with your retinol to keep your skin smooth and firm. This formula is safe and unlikely to irritate, but because it lacks acne-fighting ingredients, you should ensure your routine also includes targeted acne treatments.

### How often should I use this serum?

You can use this serum in your evening routine, applying it after your cleansing toner and before your moisturizer. Some serums can also be used in the morning or twice a day, depending on how your skin feels.

### Can it clog pores, cause breakouts or purging for acne-prone skin?

Timeless Coenzyme Q10 Serum is unlikely to clog pores or cause breakouts because it is free of harsh ingredients and uses soothing aloe vera, though it does not actively treat acne.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (benzyl alcohol).

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — €10.20 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €35.80 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/nl/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/acne-prone-skin) — Superior fit — €99.41 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/nl/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €19.20 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Matrixyl 3000, Ubiquinone, Aloe Barbadensis, Glycerin, Sodium Hyaluronate, Vitamin E, Benzyl Alcohol, Dehydroacetic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/timeless/coenzyme-q10-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/timeless/coenzyme-q10-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/timeless/coenzyme-q10-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/timeless/coenzyme-q10-serum/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/timeless/coenzyme-q10-serum/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/timeless/coenzyme-q10-serum/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/timeless/coenzyme-q10-serum/for/acne-prone-skin (this page)
- Spain: https://lovi.care/skincare/es/p/timeless/coenzyme-q10-serum/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/timeless/coenzyme-q10-serum/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/timeless/coenzyme-q10-serum/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/timeless/coenzyme-q10-serum/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/timeless/coenzyme-q10-serum/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/timeless/coenzyme-q10-serum/for/acne-prone-skin