# The Ordinary Multi-Peptide + HA Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [The Ordinary](https://lovi.care/skincare/nl/brands/the-ordinary)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your normal skin is provided by multiple peptides like Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1, which effectively target wrinkles and fine lines by stimulating collagen production and enhancing skin elasticity.
- The inclusion of Glycerin and Sodium Hyaluronate Crosspolymer further supports your skin's hydration and plumping, complementing the firming effects for a smoother appearance.
- The product is safe for your normal skin, featuring soothing ingredients like Allantoin and Sodium Hyaluronate, with no harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-ha-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-ha-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-ha-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-ha-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-ha-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-ha-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-ha-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Multi-Peptides, Sodium Hyaluronate, Lactococcus Lysate Ferment, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))

## What reviewers say

Based on a very large amount of data, users with dry, mature, or dehydrated skin frequently praise this serum for its ability to plump the skin and smooth texture, often noting a reduction in fine dehydration lines. While many appreciate it as an affordable "all-in-one" anti-aging solution, a minority of users report breakouts or a lack of visible results regarding deeper wrinkles.

- Liked: Deeply hydrates (mostly mentioned)
- Liked: Great value (often mentioned)
- Liked: Smooths texture (often mentioned)
- Liked: Plumps and firms (sometimes noted)
- Liked: Reduces fine lines (sometimes noted)
- Disliked: Conflicts with actives (sometimes noted)
- Disliked: Unclear results (sometimes noted)
- Disliked: Allergic reactions (rarely noted)
- Disliked: Causes breakouts (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes The Ordinary Multi-Peptide + HA a great fit for mature skin?

This serum is a great fit because its multiple peptides like Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1 help smooth out wrinkles and fine lines by boosting collagen and firmness. Glycerin and Sodium Hyaluronate also support deep hydration to leave your skin looking plumper and smoother.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because it contains multiple peptides like Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-1, which target wrinkles and fine lines by boosting collagen and elasticity. Glycerin and Sodium Hyaluronate further support hydration and plumping for a smoother, firmer appearance.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### What do Peptides do for mature skin?

Peptides help mature skin by triggering signals that encourage collagen production, which supports firmness and smooths the look of fine lines. They may improve skin elasticity and help repair signs of aging, though their effectiveness depends heavily on how well they penetrate the skin surface.
Sources: [International Journal of Cosmetic Science, 2009](https://pubmed.ncbi.nlm.nih.gov/19570099/), [Biomolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/39858482/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in your evening routine after cleansing and toning, and before your moisturizer. Putting treatments in the evening helps ensure safety around sun exposure.

### Can I use it with retinol, and in what order?

You can use this treatment alongside retinol by applying your retinol first, letting it absorb, and then following with this peptide serum. This combination helps smooth fine lines while keeping your skin hydrated, though using active ingredients together may occasionally cause mild tingling.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### How often should I use this serum?

You can use this treatment in the evening as part of your routine, or twice a day depending on your skin's preference. It helps smooth mature skin by targeting fine lines and boosting hydration.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/)

### Can it clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts on mature skin, as it features soothing ingredients with a very low chance of breakouts. Regular use helps keep your skin smooth and hydrated while targeting fine lines.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €160.00 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €35.50 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/nl/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — €419.00 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/nl/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €48.84 at Amazon

## Where to buy

- Amazon.nl: €18.29 (https://www.amazon.nl/dp/B0BLHW7JZM?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €18.29 (https://www.lookfantastic.nl/p/the-ordinary-multi-peptide-ha-serum-30ml/13955445/)
- Notino: €20.00 (https://www.notino.nl/the-ordinary/multi-peptide-ha-serum-verstevigende-gezichtsserum/p-16168470/)
Prices checked 14 Oct – 4 Nov 2026.

## Ingredients

Water, Glycerin, Lactococcus Lysate Ferment, Acetyl Hexapeptide-8, Pentapeptide-18, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-38, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Acetylarginyltryptophyl Diphenylglycine, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Allantoin, Glycine, Alanine, Serine, Valine, Isoleucine, Proline, Threonine, Histidine, Phenylalanine, Arginine, Aspartic Acid, Trehalose, Fructose, Glucose, Maltose, Urea, Sodium Pca, Pca, Sodium Lactate, Citric Acid, Hydroxypropyl Cyclodextrin, Sodium Chloride, Sodium Hydroxide, Butylene Glycol, Pentylene Glycol, Acacia Senegal Gum, Xanthan Gum, Carbomer, Polysorbate 20, Ppg-26-Buteth-26, Peg-40 Hydrogenated Castor Oil, Trisodium Ethylenediamine Disuccinate, Ethoxydiglycol, Sodium Benzoate, Caprylyl Glycol, Ethylhexylglycerin, Phenoxyethanol, Chlorphenesin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/the-ordinary/multi-peptide-ha-serum/for/mature-skin