# Sunday Riley A+ High-Dose Retinoid Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Sunday Riley](https://lovi.care/skincare/nl/brands/sunday-riley)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate treatment for wrinkles and fine lines on your normal skin, as hydroxypinacolone retinoate and retinol stimulate collagen and regulate desquamation, though honey extract and bisabolol provide more general hydration and soothing benefits rather than targeting your primary concern.
- The formula is highly suitable for normal skin due to the presence of these retinoids, which are effective for anti-aging.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/sunday-riley/a-high-dose-retinoid-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/sunday-riley/a-high-dose-retinoid-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/nl/p/sunday-riley/a-high-dose-retinoid-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/sunday-riley/a-high-dose-retinoid-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/sunday-riley/a-high-dose-retinoid-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/sunday-riley/a-high-dose-retinoid-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/sunday-riley/a-high-dose-retinoid-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/sunday-riley/a-high-dose-retinoid-serum/for/oily-acne-prone-skin): High

## Key ingredients

Retinoid Blend, Ubiquinone, Honey Extract, Hydroxypinacolone Retinoate, Sodium Hyaluronate Crosspolymer

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Hydroxypinacolone retinoate and retinyl propionate at a 5:9 weight ratio synergistically enhanced antiaging gene expressions in vitro and improved skin wrinkles, smoothness, transepidermal water loss, and elasticity in 42 Chinese urban women over an 8-week period without adverse reactions compared to retinol. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36762391/))
- A topical serum containing hydroxypinacolone retinoate and peptides used twice daily for 16 weeks achieved parity or statistically significantly better improvement in facial aging parameters compared to a single fractional CO2 laser treatment in women with moderate global photodamage. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39394831/))
- Topical retinoids improve global assessment scores and reduce lesion counts compared to vehicle in patients with acne vulgaris, with adapalene demonstrating a superior tolerability profile and benzoyl peroxide combination optimizing results. ([American Journal of Clinical Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30674002/))
- Topical application of all-trans-retinol induced epidermal thickening and increased retinoid binding protein expression similar to all-trans-retinoic acid in normal human skin, but without causing significant erythema or measurable retinoic acid levels. ([The Journal of Investigative Dermatology, 1995](https://pubmed.ncbi.nlm.nih.gov/7561157/))
- Trifarotene cream 0.005% resulted in a significantly greater reduction in total atrophic acne scar count compared with vehicle at Week 24 (55.2% vs 29.9%) in patients with atrophic acne scarring. ([Dermatology and Therapy, 2025](https://pubmed.ncbi.nlm.nih.gov/39984798/))
- Topical application of CoQ10 improves mitochondrial function in aging skin in vivo, combating cellular signs of aging caused by an age-dependent shift to a functionally anaerobic energy metabolism. ([BioFactors, 2008](https://pubmed.ncbi.nlm.nih.gov/19096122/))
- Encapsulating coenzyme Q10 in lipid nanoparticles for topical use improves skin compatibility, protects against degradation, increases skin penetration, and provides controlled release to counteract aging effects. ([Colloids and Surfaces. B, Biointerfaces, 2023](https://pubmed.ncbi.nlm.nih.gov/37574615/))
- Review of topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles highlights their improved bioavailability, chemical stability, skin absorption, and photoprotective effects. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34206935/))
- Honey-based dressings reduced mean healing duration, length of hospital stay, and VAS pain scores compared with povidone iodine-based dressings in 1236 participants. ([Journal of Wound Care, 2021](https://pubmed.ncbi.nlm.nih.gov/33856925/))
- Topical honey application improved the mean duration of attacks and pain, occurrence of crusting, and healing time compared to acyclovir cream in 16 adult patients with recurrent labial and genital herpes lesions. ([Medical Science Monitor, 2004](https://pubmed.ncbi.nlm.nih.gov/15278008/))
- Combined probiotic supplementation and topical azelaic acid with hydroxypinacolone retinoate reduced non-inflammatory lesions from 11.5 to 7.3 and decreased microscopic acne features measured by reflectance confocal microscopy and dynamic optical coherence tomography in 20 patients over 12 weeks. ([Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/37510902/))
- A new topical gel formulation reduced total acne lesions by 80% and GAGS scores by 78% after 8 weeks in 22 female patients with mild facial acne without impairing skin barrier function or causing side effects. ([Giornale Italiano Di Dermatologia E Venereologia, 2020](https://pubmed.ncbi.nlm.nih.gov/32869963/))
- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Users frequently praise this serum for its ability to deliver retinoid benefits like smoothed texture and reduced fine lines with minimal irritation, making it suitable for sensitive skin or retinoid beginners. The formula includes soothing botanicals that help mitigate dryness and redness, improving overall skin clarity and radiance.

- Liked: Gentle, non-irritating (mostly mentioned)
- Liked: Smoother texture (often mentioned)
- Disliked: Expensive product (often mentioned)
- Liked: Anti-aging results (sometimes noted)
- Liked: Moisturizing formula (sometimes noted)
- Disliked: Unpleasant scent (sometimes noted)
- Disliked: Initial breakouts (rarely noted)
- Disliked: Strength claims (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Sunday Riley A+ Retinoid Serum work for mature skin?

Sunday Riley A+ High-Dose Retinoid Serum works moderately well for mature skin, offering helpful anti-aging care through retinoids while providing general hydration rather than targeting wrinkles alone. Mature skin of this type needs a treatment that is exceptionally safe, highly effective at smoothing fine lines with potent ingredients, and packed with strong antioxidants and peptides for optimal elasticity and moisture.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36762391/)

### Which ingredients make this serum a good fit for mature skin?

Hydroxypinacolone retinoate and retinol make this serum a good fit for mature skin by helping smooth out wrinkles and fine lines. To fit this skin even better, a product like this needs potent antioxidants, hydrating ingredients like peptides and humectants, and skin-repairing components that improve elasticity.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36762391/)

### What does Retinoid do for mature skin?

Retinoids help smooth mature skin by boosting collagen production and encouraging skin renewal, which reduces wrinkles and improves firmness. While they are very effective, they may sometimes cause mild dryness, flaking, or irritation until your skin gets used to them.
Sources: [Clinical Interventions in Aging, 2006](https://pubmed.ncbi.nlm.nih.gov/18046911/), [International Journal of Pharmaceutics, 2015](https://pubmed.ncbi.nlm.nih.gov/26325317/)

### What does Coenzyme Q10 do for mature skin?

Coenzyme Q10 helps energize aging cells and provides strong antioxidant protection to reduce the depth of wrinkles. It supports skin metabolism and helps fight off daily stress to keep mature skin looking smooth and healthy.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39148958/), [BioFactors, 2008](https://pubmed.ncbi.nlm.nih.gov/19096122/)

### Where does this serum go in a skincare routine for mature skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safer regarding sun exposure. Mature skin needs products with powerful collagen-boosting ingredients and targeted anti-aging actives to best help with fine lines and wrinkles.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C, but it is best to apply vitamin C in the morning and save this treatment for your evening routine to keep your skin calm. Mature skin needs products packed with targeted anti-aging peptides and strong collagen-boosting ingredients for the best results.

### How often should I use this serum?

You can use this treatment in your evening routine, applying it once a day or a few times a week depending on how your mature skin feels. This serum helps smooth fine lines while keeping your skin calm, though mature skin often responds even better to formulas packed with concentrated peptides and antioxidants for deeper firming.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36762391/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause irritation on mature skin, though initial breakouts may happen in rare cases. Mature skin tackling wrinkles and fine lines often needs products rich in targeted anti-aging ingredients and deep hydrators to smooth and firm the surface.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36762391/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €160.00 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €35.50 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/nl/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — €419.00 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/nl/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €48.84 at Amazon

## Where to buy

- Amazon.nl: €311.09 (https://www.amazon.nl/dp/B07T53TFGM?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water Eau Agua, Propanediol, Dimethyl Isosorbide, Triheptanoin, Dimethicone, Glycerin, Pentylene Glycol, Hexyldecanol, Disiloxane, Cetyl Peg Ppg-10 1 Dimethicone, Diheptyl Succinate, Propylene Carbonate, Hydroxypinacolone Retinoate, Ppg-24-Glycereth-24, Phenyl Trimethicone, Retinol, Ubiquinone, Honey Extract, Sodium Hyaluronate Crosspolymer, Algae Extract, Zingiber Officinale Extract, Opuntia Ficus-Indica Fruit Extract, Bisabolol, Butyrospermum Parkii Butter Shea Butter, Yeast Extract, Lecithin, Sodium Acrylates Copolymer, Hydrogenated Polyisobutene, 1,2-Hexanediol, 4-T-Butylcyclohexanol, Polyglyceryl-10 Stearate, Caprylyl Glycol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Sorbitol, Cetylhydroxyproline Palmitamide, Polysilicone-11, Benzoic Acid, Dehydroacetic Acid, Sodium Phytate, Glyceryl Polyacrylate, Polysorbate, Hydroxyphenyl Propamidobenzoic Acid, Stearic Acid, Brassica Campestris Sterols, Pvp, Capryloyl Glycerin Sebacic Acid Copolymer, Sodium Benzoate, Alcohol, Potassium Phosphate, Decyl Glucoside, Phenoxyethanol, Hexylene Glycol, Potassium Sorbate, Tocopherol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/sunday-riley/a-high-dose-retinoid-serum/for/mature-skin