# Soolantra Cream for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Average · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/nl/p/soolantra/cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Soolantra](https://lovi.care/skincare/nl/brands/soolantra)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate treatment for skin conditions due to the presence of ivermectin, which reduces inflammation and targets parasites, but lacks specialized ingredients to effectively target your wrinkles and fine lines.
- Suitable for normal skin due to the humectant action of glycerin, but it lacks sufficient emollient ingredients like isopropyl palmitate for optimal skin hydration.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/soolantra/cream/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/nl/p/soolantra/cream/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/nl/p/soolantra/cream/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/nl/p/soolantra/cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/soolantra/cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/soolantra/cream/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/nl/p/soolantra/cream/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/soolantra/cream/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/soolantra/cream/for/oily-acne-prone-skin): Average

## Key ingredients

Ivermectin, Glycerin, Dimethicone, Carbomer, Cetyl Alcohol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- A dimethicone skin protectant lotion significantly decreased visual scoring and transepidermal water loss compared to vehicle control and SLS-only treated sites in 12 healthy humans exposed to sodium lauryl sulfate. ([Skin Research and Technology, 2000](https://pubmed.ncbi.nlm.nih.gov/11428946/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))
- Topical chloramphenicol-betamethasone combined with sodium hyaluronate/trehalose/carbomer gel compared to chloramphenicol-betamethasone alone reduced most subjective symptoms at 1 week but increased blurred vision at 4 weeks following strabismus surgery in 31 patients, with no significant differences in conjunctival inflammation between treatments. ([Journal of Ocular Pharmacology and Therapeutics, 2019](https://pubmed.ncbi.nlm.nih.gov/31298607/))
- Incorporating nanoemulsions into hydrogels with increasing Carbopol 934 proportions from 1% to 3% progressively decreased the percutaneous flux rates of terbinafine and citral, increased drug accumulation in the stratum corneum while decreasing it in the epidermis/dermis compared to nanoemulsions alone, and shifted delivery routes from skin appendages to intercellular paths. ([International Journal of Nanomedicine, 2016](https://pubmed.ncbi.nlm.nih.gov/27877042/))
- Topical liquiritin carbomer gel treatment restored skin barrier function, increased barrier proteins and antioxidant enzymes, and decreased inflammatory cytokines and oxidative stress in a mouse model of glucocorticoid-induced skin inflammation. ([Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/39204346/))
- A soap-free cleansing lotion containing cetyl alcohol and sodium cocoyl apple amino acids reduced skin surface impurities and improved skin hydration, barrier function, and skin tone in 27 healthy adult subjects over 30 days. ([Cureus, 2025](https://pubmed.ncbi.nlm.nih.gov/40978887/))

## Why other serums fit mature skin better

- Topical application of retinol and retinoic acid both increased epidermal thickness and upregulated collagen genes and proteins in human skin, with retinol producing similar histological and molecular changes to retinoic acid alongside a significant reduction in facial wrinkles after 12 weeks. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26578346/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))

## What reviewers say

A notable portion of users experience an initial worsening of their skin, including breakouts and irritation, during the first few weeks of use before seeing improvements, indicating a need for patience.

- Liked: Clears pustules (mostly mentioned)
- Liked: Life-changing results (often mentioned)
- Liked: Reduces redness (often mentioned)
- Disliked: Initial flare-up (often mentioned)
- Liked: Improves texture (sometimes noted)
- Disliked: High cost (sometimes noted)
- Disliked: Slow onset (sometimes noted)
- Disliked: Burning or itching (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Soolantra Cream work for mature skin?

Soolantra Cream works moderately well for mature skin because its ivermectin helps calm irritation, but it lacks specialized ingredients to effectively target wrinkles and fine lines. To truly care for mature skin, a product of this type needs high-quality anti-aging ingredients, potent antioxidants, skin-repairing components, and rich nourishing oils or peptides for deep hydration.

### Which ingredients make this cream a good fit for mature skin?

Glycerin helps keep mature skin soft and hydrated by drawing in moisture. A cream for this skin also needs potent antioxidants, nourishing oils, peptides, and ingredients that effectively target wrinkles and fine lines.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Glycerin do for mature skin?

Glycerin helps keep mature skin feeling soft and smooth by drawing moisture into the outer layer and locking it in. This daily hydration boost supports the skin barrier, keeping dry areas comfortable and protected against irritation.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Where does this cream go in a skincare routine for mature skin?

This cream goes in the evening routine after cleansing and before moisturizing, though mature skin also needs specialized ingredients to smooth out wrinkles and fine lines.

### Can I use this cream with retinol, and in what order?

You can use this treatment with retinol by applying the retinol first and following with this cream, or by using them on alternate nights to keep your skin calm. This product works for your skin, though it lacks specialized ingredients for fine lines and wrinkles, so a mature skin routine also needs firming peptides and rich softening ingredients to keep skin smooth.

### How often should I use this cream?

You can use this treatment in the evening as part of your routine. Daily use helps reduce inflammation, though mature skin also needs specialized anti-aging ingredients and rich moisturizers to smooth fine lines and keep skin soft.

### Can this cream clog pores, cause breakouts or purging for mature skin?

This cream is unlikely to clog pores or cause breakouts for mature skin, though you may experience an initial flare-up or mild burning when you start using it. To best care for mature skin, a product of this type needs richer softening ingredients like isopropyl palmitate to keep skin hydrated and plump.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol, stearyl alcohol, and oleyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €160.00 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €35.50 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/nl/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — €419.00 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/nl/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €48.84 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Ivermectin, Glycerin, Isopropyl Palmitate, Carbomer, Dimethicone, Disodium Edta, Citric Acid, Cetyl Alcohol, Stearyl Alcohol, Sorbitan Stearate, Methyl Parahydroxybenzoate, Propyl Parahydroxybenzoate, Phenoxyethanol, Propylene Glycol, Oleyl Alcohol, Sodium Hydroxide, Water
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/soolantra/cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/soolantra/cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/soolantra/cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/soolantra/cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/soolantra/cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/soolantra/cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/soolantra/cream/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/soolantra/cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/soolantra/cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/soolantra/cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/soolantra/cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/soolantra/cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/soolantra/cream/for/mature-skin