🇳🇱Netherlands

SkinMedica TNS Advanced+ Serum for dry sensitive skin

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

SkinMedica TNS Advanced+ Serum
  • Human Fibroblast Conditioned Media
  • Collagen Peptides
  • Trifluoroacetyl Tripeptide-2
  • Glycerin
  • Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract

Average

  • HighDry Skin Fit
  • AverageEffectiveness
  • HighSafety

Works for dry sensitive skin; other serums fit it better.

This fit is calculated for the concerns frequently associated with dry sensitive skin: flakiness, tightness, redness, fine lines, and wrinkles. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • This serum offers excellent skin rejuvenation for you, with Human Fibroblast Conditioned Media and Trifluoroacetyl Tripeptide-2 improving skin texture and reducing fine lines, while Glycerin and Saccharide Isomerate provide essential hydration for your dry skin.
  • Shea Ethyl Esters Butter further supports your dry skin by offering emollient action, and the formula is safe for your sensitive skin due to the absence of harsh ingredients.
  • The product is safe for your dry and sensitive skin as it contains no prohibited or harsh ingredients, and it provides general skincare benefits like hydration and soothing.

How to apply

  • Use this PM routine for your evening skincare. Start using the serum 3 times a week and increase to daily use if your skin feels comfortable.
  • Apply the serum after cleansing and toner, but right before your moisturizer. This step locks in deep hydration for dry skin.
  • Gently press 2-3 drops of the serum into your skin using your palms. Let it absorb completely for a minute ⏱ before applying your next product.
  • Since your skin is sensitive, apply the serum on completely dry skin for better tolerance and less irritation.
  • Avoid the sensitive eye area during application. Always do a patch test before your first use to ensure your skin reacts well.

People Say

★4.5Overall rating based on 5.2k+ reviews

Based on a very large amount of data, this serum is highly praised for its potent anti-aging benefits, specifically targeting coarse wrinkles, fine lines, and sagging skin to produce a firmer, more radiant complexion. Users frequently report visible improvements in skin texture and elasticity. However, the product's high price tag and recurring issues with its dual-chamber pump packaging are common points of frustration.

Highlights

  • Improves fine lines Mostly Mentioned
    • “can make the world of difference in your fine lines and wrinkles”
    • “deeper lines around my mouth lessened significantly”
    • “notice an improvement in fines lines”
    • “creases in my forehead became more shallow”
  • Very expensive price Mostly Mentioned
    • “The price tag is steep”
    • “Expensive but fast results!”
    • “The price is ridiculous”
    • “A lot of money for a flawed product”
  • Firms sagging skin Often Mentioned
    • “my skin had much more elasticity”
    • “feels firmer, stays well hydrated”
    • “preventing/restoring sagging skin”
    • “plumps and firms with zero irritation”
  • Smoothes skin texture Often Mentioned
    • “My skin looks smoother”
    • “enhanced skin texture and tone”
    • “overall glow to my skin”
    • “visibly softer skin and improved texture”
  • Faulty pump dispenser Often Mentioned
    • “One of the pumps failed on me”
    • “The pumps did not work properly”
    • “faulty pump & other issues”
    • “dual pump failure issue”
  • Safe for sensitive skin Sometimes Noted
    • “anti aging treatment that works for sensitive skin”
    • “enhanced my skin without causing irritation”
    • “plumps and firms with zero irritation”
    • “Safe for sensitive skin”
  • Uneven product dispensing Sometimes Noted
    • “serum ran out before the cream that you mix it with”
    • “never know whether I'm getting enough from each side”
    • “only have the clear serum but not the white one coming out”
    • “They didn't dispense evenly”

Sources: lovi.care, dermapproved.com, lovelyskin.com, ellemesmedspa.com, walmart.com, theskinspot.com, and more

Questions and answers

How well does SkinMedica TNS Advanced+ Serum work for dry sensitive skin?

SkinMedica TNS Advanced+ Serum works for dry sensitive skin, though other products fit it better because your skin needs a product that provides maximum hydrating and nourishing ingredients, optimal moisture retention, skin barrier support, ceramides, and multiple forms of vitamin C without any risk of unsuitability.

Clinical, Cosmetic and Investigational Dermatology, 2017The Journal of Dermatological Treatment, 2025

Which ingredients make this serum a good fit for dry sensitive skin?

Glycerin, saccharide isomerate, and shea ethyl esters make this serum a good fit by bringing much-needed hydration and comfort to dry skin. To best fit dry sensitive skin, a treatment of this type needs rich moisturizing components and barrier-supporting ingredients that deliver hydration without any risk of irritation.

Clinical, Cosmetic and Investigational Dermatology, 2017The Journal of Dermatological Treatment, 2025

What does Human Fibroblast Conditioned Media do for dry sensitive skin?

Human Fibroblast Conditioned Media helps keep dry sensitive skin calm and soft by supporting the skin barrier and reducing irritation. For the best results on this skin type, it needs to be paired with soothing ingredients like ceramides and hyaluronic acid to lock in moisture and prevent flaking.

Frontiers in Microbiology, 2026

What do Collagen Peptides do for dry sensitive skin?

Collagen peptides help keep dry sensitive skin hydrated, smooth, and calm by supporting the skin barrier and moisture levels. Daily use is unlikely to cause irritation and may significantly reduce dryness and roughness over time.

International Journal of Cosmetic Science, 2009Nutrients, 2021

Where does this serum go in a skincare routine for dry sensitive skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing. A product for dry sensitive skin needs rich hydrators like glycerin and soothing ingredients to calm the skin while avoiding any harsh additives.

Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying your retinol first and following with this treatment, or by using retinol at night and this serum in the morning to keep your dry sensitive skin calm. This serum works for your skin, but dry sensitive skin needs products packed with soothing ingredients and extra moisture to feel fully comfortable.

How often should I use this serum?

You can use this serum in your evening routine, as treatments fit simply and safely there. Dry sensitive skin works with this serum, though it needs extra hydrating ingredients like hyaluronic acid and richer softening oils to feel fully comfortable.

Can this serum clog pores, cause breakouts or purging for dry sensitive skin?

This serum is unlikely to clog pores or cause breakouts for dry sensitive skin because it is free of harsh ingredients, though a product of this type needs rich hydrators and soothing agents to fully comfort this skin type. It does not cause purging since it lacks active ingredients that speed up cell turnover.

Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

What the research says

  • A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

    Clinical, Cosmetic and Investigational Dermatology, 2017

  • A novel moisturizer containing saccharide isomerate accelerates skin barrier recovery, improves hydration, reduces erythema, and alleviates discomfort compared to a control moisturizer following intense pulsed light treatment in subjects with skin aging.

    The Journal of Dermatological Treatment, 2025

  • A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic.

    Journal of Cosmetic Dermatology, 2021

  • Exposure to collagen peptides increased the expression of COL1A1, ELN, and VCAN genes and collagen protein levels in cultured human dermal fibroblasts compared to untreated controls.

    Frontiers in Medicine, 2024

  • Salmo salar and Tilapia nilotica skin collagen peptides accelerate wound healing in a rat murine wound model by reducing proinflammatory cytokines, upregulating BD14, NOD2, IL-10, VEGF, and beta-FGF, and favorably altering wound microflora colonization compared to untreated controls.

    Journal of Agricultural and Food Chemistry, 2020

  • The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

    Journal of Cosmetic Dermatology, 2020

  • Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

    International Journal of Cosmetic Science, 2001

  • Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

    Journal of Drugs in Dermatology, 2012

Ingredients

Water, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Ethyl Esters Butter, Glycerin, Ethoxydiglycol, Lactococcus Lysate Ferment, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Trifluoroacetyl Tripeptide-2, Dimer Tripeptide-43, Hydrolyzed Linseed Extract, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, Peg-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Dextran, Disodium Edta, Phenoxyethanol, Ethylhexylglycerin

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

How does it fit your skin?

Scan your face, then any product.

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How does it fit your skin?

Scan your face, then any product: Lovi shows how well it fits you and what fits even better.

QR code: get the Lovi app
Download on theApp Store Get it onGoogle Play