SkinMedica TNS Advanced+ Serum for acne-prone skin
Human Fibroblast Conditioned Media
Collagen Peptides
Trifluoroacetyl Tripeptide-2
Glycerin
Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract
High
- SuperiorCombination Skin Fit
- HighEffectiveness
- HighSafety
A great choice for acne-prone skin; a few serums fit it even better.
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Excellent suitability for your combination skin is provided by Human Fibroblast Conditioned Media and Whey Protein, which stimulate collagen and repair your skin barrier, addressing your acne and breakouts.
- Lactococcus Lysate Ferment further supports inflammation reduction, contributing to smoother texture and minimized fine lines.
- The safety profile is excellent, with no risks of irritation due to the absence of prohibited or harsh ingredients.
How to apply
- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
People Say
★4.5Overall rating based on 5.2k+ reviewsBased on a very large amount of data, this serum is highly praised for its potent anti-aging benefits, specifically targeting coarse wrinkles, fine lines, and sagging skin to produce a firmer, more radiant complexion. Users frequently report visible improvements in skin texture and elasticity. However, the product's high price tag and recurring issues with its dual-chamber pump packaging are common points of frustration.
Highlights
Improves fine lines Mostly Mentioned
- “can make the world of difference in your fine lines and wrinkles”
- “deeper lines around my mouth lessened significantly”
- “notice an improvement in fines lines”
- “creases in my forehead became more shallow”
Very expensive price Mostly Mentioned
- “The price tag is steep”
- “Expensive but fast results!”
- “The price is ridiculous”
- “A lot of money for a flawed product”
Firms sagging skin Often Mentioned
- “my skin had much more elasticity”
- “feels firmer, stays well hydrated”
- “preventing/restoring sagging skin”
- “plumps and firms with zero irritation”
Smoothes skin texture Often Mentioned
- “My skin looks smoother”
- “enhanced skin texture and tone”
- “overall glow to my skin”
- “visibly softer skin and improved texture”
Faulty pump dispenser Often Mentioned
- “One of the pumps failed on me”
- “The pumps did not work properly”
- “faulty pump & other issues”
- “dual pump failure issue”
Safe for sensitive skin Sometimes Noted
- “anti aging treatment that works for sensitive skin”
- “enhanced my skin without causing irritation”
- “plumps and firms with zero irritation”
- “Safe for sensitive skin”
Uneven product dispensing Sometimes Noted
- “serum ran out before the cream that you mix it with”
- “never know whether I'm getting enough from each side”
- “only have the clear serum but not the white one coming out”
- “They didn't dispense evenly”
Sources: lovi.care, dermapproved.com, lovelyskin.com, ellemesmedspa.com, walmart.com, theskinspot.com, and more
Questions and answers
What makes SkinMedica TNS Advanced+ Serum a great fit for acne-prone skin?
SkinMedica TNS Advanced+ Serum is a great fit because Human Fibroblast Conditioned Media and whey protein repair your skin barrier and stimulate collagen to help address breakouts. Lactococcus Lysate Ferment further calms inflammation, which helps give you smoother skin.
Dermatologic Surgery, 2024International Journal of Pharmaceutics, 2024
Which ingredients make this serum a good fit for acne-prone skin?
Human fibroblast conditioned media and whey protein make this serum a great fit because they help repair your skin barrier and address breakouts. Lactococcus lysate ferment also helps reduce inflammation to give you smoother skin.
Dermatologic Surgery, 2024International Journal of Pharmaceutics, 2024
What does Human Fibroblast Conditioned Media do for acne-prone skin?
Human Fibroblast Conditioned Media helps stimulate skin recovery and quality, but for acne-prone skin, it also needs ingredients that clear pores and calm breakouts to keep skin smooth and clear.
What do Collagen Peptides do for acne-prone skin?
Collagen peptides are unlikely to directly treat acne, but they help improve overall skin hydration and elasticity. To properly care for acne-prone skin, this product needs ingredients that gently clear pores and calm irritation.
Where does this serum go in a skincare routine for acne-prone skin?
This serum goes in the evening routine after cleansing and toning, and before moisturizing. Putting treatments in the evening provides simplicity and extra safety around sun exposure.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first and following it with your retinol. Because this product is gentle and free of harsh ingredients, it is unlikely to cause irritation when paired with active treatments.
How often should I use this serum?
This serum is used in the evening as part of your routine. It helps calm breakouts and smooth your skin safely without irritation.
Dermatologic Surgery, 2024International Journal of Pharmaceutics, 2024
Can this serum clog pores, cause breakouts or purging for acne-prone skin?
This serum is a great fit for acne-prone skin because ingredients like Human Fibroblast Conditioned Media, whey protein, and Lactococcus Lysate Ferment help repair your skin barrier and reduce inflammation without clogging pores. It has an excellent safety profile with no harsh ingredients, making it unlikely to cause irritation, breakouts, or purging.
Dermatologic Surgery, 2024International Journal of Pharmaceutics, 2024
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic.
Journal of Cosmetic Dermatology, 2021Exposure to collagen peptides increased the expression of COL1A1, ELN, and VCAN genes and collagen protein levels in cultured human dermal fibroblasts compared to untreated controls.
Frontiers in Medicine, 2024Salmo salar and Tilapia nilotica skin collagen peptides accelerate wound healing in a rat murine wound model by reducing proinflammatory cytokines, upregulating BD14, NOD2, IL-10, VEGF, and beta-FGF, and favorably altering wound microflora colonization compared to untreated controls.
Journal of Agricultural and Food Chemistry, 2020A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001
Ingredients
Water, Pentylene Glycol, Human Fibroblast Conditioned Media, Glycereth-7 Triacetate, Shea Ethyl Esters Butter, Glycerin, Ethoxydiglycol, Lactococcus Lysate Ferment, Whey Protein, Chlorella Vulgaris Extract, Saccharide Isomerate, Trifluoroacetyl Tripeptide-2, Dimer Tripeptide-43, Hydrolyzed Linseed Extract, Vitis Vinifera Flower Cell Extract Grape Flower Cell Extract, Pyrus Malus Fruit Extract, Hydroxyacetophenone, Tocopheryl Acetate, Propanediol, Xanthan Gum, Polyacrylate Crosspolymer-6, Polyacrylate-13, Polyisobutene, Sclerotium Gum, Peg-12 Dimethicone, Lecithin, Pullulan, Butylene Glycol, Sodium Citrate, Polysorbate 20, Aminomethyl Propanol, Dextran, Disodium Edta, Phenoxyethanol, Ethylhexylglycerin
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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