# Skin Better Science Alto Advanced Defense and Repair Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Skin Better Science](https://lovi.care/skincare/nl/brands/skin-better-science)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- This serum offers moderate benefits for your normal skin, with niacinamide and tetrahexyldecyl ascorbate providing antioxidant activity and barrier repair to support overall skin health. Glycerin and tetrahexyldecyl ascorbate offer general hydration and antioxidant support, which can be beneficial for wrinkles and fine lines.
- The formula is excellent for protecting against environmental stressors due to ergothioneine and arabidopsis thaliana extract, which are well-suited for normal skin.
- The product is safe for your normal skin, as it contains no harsh ingredients that would cause irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Superoxide Dismutase, Tetrahexyldecyl Ascorbate, Carnosine, Ceramide Ap

## What the research says

- A triple combination of ergothioneine, collagen peptides, and sodium hyaluronate attenuated UV-induced skin damage ex vivo and improved facial skin hydration, elasticity, barrier function, and wrinkles in Chinese women. ([Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/))
- Topical application of photolyase-containing liposomes followed by photoreactivating light decreased UVB-induced dimers by 40-45% and prevented immunosuppression, erythema, and sunburn-cell formation in healthy human subjects. ([Proceedings of the National Academy of Sciences of the United States of America, 2000](https://pubmed.ncbi.nlm.nih.gov/10660687/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls. ([International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18492138/))
- Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable. ([European Journal of Pharmaceutics and Biopharmaceutics, 2007](https://pubmed.ncbi.nlm.nih.gov/17196809/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- A night cream containing melatonin, carnosine, and Helichrysum italicum extract reduced oxidative stress ex vivo and improved hydration, reduced transepidermal water loss, decreased wrinkles and spots, and lowered skin reactivity in 117 individuals over up to 12 weeks of nightly use. ([Dermatology and Therapy, 2020](https://pubmed.ncbi.nlm.nih.gov/32915393/))
- Supramolecular carnosine improves skin reactivity, upregulates Nrf2 expression, activates antioxidant defenses, and reduces AGE levels while demonstrating whitening efficacy in cells and clinical tests compared to conventional carnosine. ([Advanced Healthcare Materials, 2024](https://pubmed.ncbi.nlm.nih.gov/39279568/))
- A targeted skincare regimen containing active ingredients such as rhodophyceae extract, ergothioneine, and L-carnosine significantly reduced transepidermal water loss by 24.09%, improved skin elasticity, and decreased redness, dryness, and desquamation in thirty-five female Chinese participants over 4 weeks following advanced optimal pulse technology treatment. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40497421/))

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Alto Advanced Defense and Repair Serum work for mature skin?

This serum works moderately well for mature skin, providing antioxidant protection and barrier support with ingredients like niacinamide and tetrahexyldecyl ascorbate. To truly fit mature skin best, a product of this type needs high concentrations of potent antioxidants, peptides, and hydrating ingredients to effectively target wrinkles and fine lines while improving elasticity.
Sources: [Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/)

### Which ingredients make this serum a good fit for mature skin?

Niacinamide, tetrahexyldecyl ascorbate, ergothioneine, and arabidopsis thaliana extract help protect and support mature skin by providing antioxidant defense and hydration. A treatment for mature skin needs potent antioxidants, peptides, and hydrating ingredients to effectively smooth fine lines and improve elasticity.
Sources: [Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Superoxide Dismutase do for mature skin?

Superoxide Dismutase helps protect mature skin from daily oxidative stress and breakdown. Products for this skin need antioxidants and ingredients that support firmness.

### Where does it go in a skincare routine for mature skin?

This treatment serum goes in the evening routine after cleansing and toning, and before your moisturizer. Mature skin also needs targeted ingredients like retinoids or peptides to better smooth fine lines and improve firmness.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the treatment after cleansing and before moisturizing, though mature skin often needs richer anti-aging ingredients and deep hydration to best target fine lines.

### How often should I use it?

You can use this treatment in your evening routine for simplicity and extra safety around sun exposure. This mature skin needs products featuring nourishing hydrators and firming peptides to effectively target wrinkles and fine lines.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts on mature skin, as it contains no harsh ingredients that typically lead to irritation. To best care for mature skin, a product of this type needs rich hydrators like glycerin and hyaluronic acid along with firming peptides to smooth fine lines.

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €160.00 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €35.50 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/nl/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — €419.00 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/nl/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €48.84 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Acacia Decurrens Wax Flower, Acacia Senegal Gum, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Water, Arabidopsis Thaliana Extract, Arginine, Benzylidene Dimethoxydimethylindanone, Bisabolol, Buddleja Officinalis Flower Extract, Butylene Glycol, Camellia Sinensis Leaf Extract, Carbomer, Carnosine, Ceramide Ap, Ceramide Eop, Ceramide Np, Cetearyl Alcohol, Ceteth-20 Phosphate, Chlorogenic Acids, Cholesterol, Citric Acid, Coffea Arabica Extract Cell Leaf Coffee Extract Cell Leaf, Crocus Sativus Extract Cell Leaf Culture, Curcuma Longa Root Extract, Dextran, Dicetyl Phosphate, Diisostearyl Malate, Dimethyl Isosorbide, Ergothioneine, Ethylhexyl Olivate, Ethylhexylglycerin, Euterpe Oleracea Fruit Extract, Glycerin, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Helianthus Annuus Wax Seed Sunflower Wax Seed, Hydrolyzed Sodium Hyaluronate, Jojoba Esters, Lauryl Lactate, Lecithin, Linoleic Acid, Linolenic Acid, Methyl Gluceth-20, Micrococcus Lysate, Niacinamide, Olea Europaea Fruit Extract Olive Fruit Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Pentylene Glycol, Phenoxyethanol, Phytosphingosine, Plankton Extract, Polyglycerin-3, Propanediol, Propanediol Dicaprylate Caprate, Pyrroloquinoline Quinone Allyl Ester, Ricinoleth-40, Sea Whip Extract, Sodium Hydroxide, Sodium Lauroyl Lactylate, Sodium Pca, Sodium Phytate, Steareth-2, Superoxide Dismutase, Tetrahexyldecyl Ascorbate, Theobroma Cacao Seed Extract, Tocopherol, Tocopheryl Acetate, Trifluoroacetyl Tripeptide-2, Ubiquinone, Vitis Vinifera Seed Extract Grape Seed Extract, Xanthan Gum, Zingiber Officinale Root Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin