# Shiseido Vital Perfection Intensive WrinkleSpot Treatment for oily acne-prone skin

**Lovi Fit: Average fit for oily acne-prone skin.**
Oily Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Shiseido](https://lovi.care/skincare/nl/brands/shiseido)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for oily acne-prone skin; other serums fit it better.

## Why this fit

- Offers excellent wrinkle reduction for you due to the presence of retinol and retinyl acetate in moderate concentrations for minimizing fine lines and wrinkles, though it lacks specialized ingredients like salicylic acid or niacinamide to effectively address your acne, blemishes, and breakouts, and oiliness.
- Caffeine offers vasoconstrictive effects suitable for oily skin, but the formula lacks sufficient ingredients for strong seboregulation.
- The product is safe for your oily skin due to the absence of harsh ingredients and the presence of soothing ingredients like Rosa Damascena Flower Water and Glycyrrhiza Glabra Root Extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/nl/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/oily-acne-prone-skin): Average (this page)

## Key ingredients

Retinol, 4msk, Kurenai-Trulift Complex, Reneura Technology, Glycyrrhiza Glabra Root Extract Licorice Root Extract

## What the research says

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical caffeine acts as an active cosmetic compound by preventing excessive fat accumulation through phosphodiesterase inhibition, protecting cells against UV radiation with antioxidant properties, increasing skin microcirculation, and stimulating hair growth via 5-alpha-reductase inhibition. ([Skin Pharmacology and Physiology, 2013](https://pubmed.ncbi.nlm.nih.gov/23075568/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of all-trans-retinol induced epidermal thickening and increased retinoid binding protein expression similar to all-trans-retinoic acid in normal human skin, but without causing significant erythema or measurable retinoic acid levels. ([The Journal of Investigative Dermatology, 1995](https://pubmed.ncbi.nlm.nih.gov/7561157/))
- Potassium 4-methoxysalicylate (4MSK) suppresses melanin content, promotes keratinocyte differentiation, increases skin lightness in pigmented and non-pigmented cheek areas, and reduces the desquamation area ratio. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40071590/))
- An in situ hydrated ionic liquid-like state strategy using potassium 4-methoxysalicylate and arginine hydrochloride increased human skin permeation to 237% of control and reduced melanin content by 33% in a reconstructed human epidermis model. ([International Journal of Pharmaceutics, 2026](https://pubmed.ncbi.nlm.nih.gov/42822711/))
- Plant extracts from Gomphrena globasa L., Clitoria ternatea L., Carthamus tinctorius L., Punica granatum L., and Papaver rhoeas L. demonstrated no cytotoxicity, high antioxidant potential, strong collagenase inhibition, moderate elastase inhibition, effective skin hydration, and varying suitability as stable cosmetic dyes when tested on keratinocyte and fibroblast cell lines and incorporated into face cream formulations. ([Molecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34068613/))
- Water extracts of Papaver rhoeas L., Punica granatum L., Clitoria ternatea L., Carthamus tinctorius L., and Gomphrena globosa L. showed no cytotoxicity on skin cells while exhibiting antioxidant, anti-inflammatory, and enzyme-inhibiting properties, with P. rhoeas, C. ternatea, and C. tinctorius demonstrating strong permanent coloring ability in cosmetic products. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35164187/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of Glycyrrhiza glabra and Sophora japonica flavonoid-rich fractions individually and in combination significantly increased the wound healing rate and reduced oxidative stress compared to wound and Nolaver-treated groups. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37049756/))

## Why other serums fit oily acne-prone skin better

- Adapalene 0.1%-benzoyl peroxide 2.5% fixed-dose combination gel provided significantly greater, synergistic efficacy and a faster onset of action compared with the vehicle, adapalene monotherapy, and benzoyl peroxide monotherapy in patients with acne vulgaris. ([The British Journal of Dermatology, 2009](https://pubmed.ncbi.nlm.nih.gov/19466959/))
- Topical benzoyl peroxide 5% gel treatment improved acne severity, sebum, stratum corneum hydration, and transepidermal water loss, while significantly reducing microbial diversity and the prevalence of Cutibacterium in 33 patients with acne vulgaris. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34962033/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))

## What reviewers say

Based on a very large amount of data, users with mature or aging skin frequently report that this treatment visibly softens deep wrinkles and fades dark spots. Many users also note improvements in skin firmness and appreciate the effective targeted application. Some users with sensitive skin experience dryness or irritation, and a low number find the texture heavy or the product ineffective for their needs.

- Liked: Reduces wrinkles (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Improves firmness (sometimes noted)
- Liked: Targeted application (sometimes noted)
- Disliked: Causes dryness (sometimes noted)
- Disliked: High price (sometimes noted)
- Disliked: Irritates skin (sometimes noted)
- Disliked: Heavy texture (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Shiseido Intensive WrinkleSpot Treatment work for oily acne-prone skin?

This treatment works for your oily acne-prone skin, though other products fit it better because it lacks ingredients to manage breakouts and oiliness. A treatment of this type needs acne-fighting ingredients like niacinamide, propolis, benzoyl peroxide, or Vitamin C to address breakouts while keeping skin comfortable and balanced.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Which ingredients make this treatment a good fit for oily acne-prone skin?

This treatment fits oily acne-prone skin through the inclusion of soothing licorice root extract and rose water, which help calm the skin without heavy or harsh ingredients. However, because it lacks targeted ingredients for breakouts and excess oil, an oily skin type needs a treatment featuring ingredients like niacinamide, salicylic acid, or benzoyl peroxide to properly clear blemishes and control oil.
Sources: [Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/)

### What does Retinol do for oily acne-prone skin?

Retinol helps oily acne-prone skin by clearing up breakouts and smoothing the skin, though it may occasionally cause some mild scaling or stinging. This ingredient works by addressing the root causes of acne, making it a reliable choice for keeping pores clear and skin smooth.
Sources: [American Journal of Clinical Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30674002/), [Journal of Drugs in Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/30586483/)

### What does 4-Methoxy potassium salicylate do for oily acne-prone skin?

Potassium 4-methoxysalicylate helps clear dark spots and brightens your complexion by slowing down melanin production and smoothing the skin surface. However, since this type of product is not formulated for breakouts, oily acne-prone skin needs a product that includes clarifying ingredients like salicylic acid or niacinamide to help control excess oil and keep pores clear.
Sources: [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40071590/)

### Where does this treatment go in a skincare routine for oily acne-prone skin?

This treatment goes in your evening routine, applied after your cleansing toner and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure for this skin type.

### Can I use this treatment with vitamin C, and in what order?

You can use this treatment alongside vitamin C, but it is best to apply vitamin C in the morning and save this treatment for your evening routine to keep your skin calm. Using them at different times of day helps your skin handle both ingredients comfortably without feeling overloaded.

### How often should I use this treatment?

This treatment should be used in the evening, applying it as part of your nighttime routine. Oily and acne-prone skin of this type needs a product that also includes oil-controlling and breakout-clearing ingredients like salicylic acid or niacinamide.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this treatment clog pores, cause breakouts or purging for oily acne-prone skin?

This treatment may cause breakouts for oily acne-prone skin because it lacks targeted ingredients like salicylic acid or niacinamide to manage oil and blemishes, and reviewer complaints indicate moderate irritation and dryness that can disrupt sensitive skin. A product of this type needs salicylic acid, niacinamide, or oil-balancing agents to properly clear breakouts and control oil.

### Is this treatment fragrance-free and alcohol-free?

It contains fragrance (parfum, limonene, hexyl cinnamal, linalool, and citronellol) and drying alcohol (alcohol).

## Alternatives for oily acne-prone skin

- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/nl/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/oily-acne-prone-skin) — Superior fit — €99.41 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — €10.20 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — €35.50 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/nl/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — €29.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/nl/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/oily-acne-prone-skin) — Superior fit — €19.20 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentaerythrityl Tetraethylhexanoate, Dipropylene Glycol, Hydrogenated Polydecene, Glycerin, Betaine, Behenyl Alcohol, Dimethicone, Potassium Methoxysalicylate, Petrolatum, Hydrogenated Palm Oil, Stearyl Alcohol, Maltitol, Beheneth-20, Palm Kernel Oil, Phenoxyethanol, Butylene Glycol, Palm Oil, Carnauba Wax Cera Copernicia Cerifera Cire De Carnauba Wax Cera, Hydrogenated Polyisobutene, Polyvinyl Alcohol, Microcrystalline Wax Cera Microcristallina Cire Microcristalline Wax Cera, Parfum, Carbomer, Tocopheryl Acetate, Rosa Damascena Flower Water, Xanthan Gum, Bht, Retinol, Polysorbate 20, Alcohol, Caffeine, Potassium Hydroxide, Lavandula Angustifolia Oil Lavender Oil, Trisodium Edta, Ppg-3 Dipivalate, Limonene, Tocopherol, Hexyl Cinnamal, Linalool, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Citronellol, Angelica Acutiloba Root Extract, Angelica Keiskei Stem Extract Leaf, Olea Europaea Leaf Extract Olive Leaf Extract, Sanguisorba Officinalis Root Extract, Lamium Album Stem Extract Flower Leaf, Camellia Sinensis Leaf Extract, Inositol, Carthamus Tinctorius Flower Extract, Pinus Sylvestris Cone Extract, Ziziphus Jujuba Fruit Extract, Retinyl Acetate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Cellulose, Beta-Carotene, Cinnamomum Cassia Bark Extract, Citric Acid, Bupleurum Falcatum Root Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/oily-acne-prone-skin
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- Italy: https://lovi.care/skincare/it/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/oily-acne-prone-skin (this page)
- Spain: https://lovi.care/skincare/es/p/shiseido/vital-perfection-intensive-wrinklespot-treatment/for/oily-acne-prone-skin
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