# Peter Thomas Roth Retinol Fusion PM Night Serum for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/nl/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Peter Thomas Roth](https://lovi.care/skincare/nl/brands/peter-thomas-roth)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, this serum utilizes retinol to regulate desquamation and bisabolol for anti-inflammatory action, addressing your concerns with acne and blemishes by promoting cell turnover.
- The inclusion of squalane and tocopheryl acetate further supports skin renewal and provides antioxidant benefits, contributing to a smoother complexion.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/nl/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/nl/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Microencapsulated Retinol, Vitamins C, Squalane, Bisabolol, Cyclopentasiloxane

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Co-encapsulation of alpha-tocopherol and alpha-tocopheryl acetate in nanostructured lipid carrier gel formulations significantly enhanced moisture retention up to 68% and improved skin elasticity in human volunteers compared to a solution gel. ([Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/))
- Topical application of a vitamin C-squalene bioconjugate significantly increased epidermal thickness, type III collagen production, and glycosaminoglycans production in human skin explants compared to free vitamin C and vitamin C-palmitate. ([Scientific Reports, 2020](https://pubmed.ncbi.nlm.nih.gov/33037252/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Cyclomethicone and specific chain length cyclic siloxanes (n = 4-7) are safe in present practices of use and concentration, showing minimal percutaneous absorption, no skin irritation or sensitization, and unlikely significant systemic exposure from cosmetics. ([International Journal of Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/22247236/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Application of an alpha-bisabolol-containing cream produced a significant skin-lightening effect in pigmented skin compared to a vehicle control in the majority of female subjects after 8 weeks. ([International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/20642768/))
- The combination of allantoin, bisabolol, D-panthenol and dipotassium glycyrrhizinate reduces UVB-induced PGE2, inflammatory cytokines, and mitochondrial superoxide in human epidermal keratinocytes. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38433250/))

## What reviewers say

Based on a very large amount of data, this retinol serum is highly regarded for its anti-aging effects, including smoothing fine lines and improving skin texture, with most users experiencing a radiant and refined complexion without irritation. Some users reported a lack of visible results or found the thin consistency and premium price point to be drawbacks.

- Liked: Non-irritating formula (mostly mentioned)
- Liked: Reduces fine lines (often mentioned)
- Liked: Smoother texture (often mentioned)
- Liked: Absorbs quickly (sometimes noted)
- Liked: Radiant complexion (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Lack of results (sometimes noted)
- Disliked: Oily feel (rarely noted)
- Disliked: Thin consistency (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Peter Thomas Roth Retinol Fusion PM Night Serum a great fit for acne-prone skin?

This serum is a great fit because retinol helps clear blemishes by speeding up cell turnover, while bisabolol calms redness. It also keeps your skin smooth and protected with squalane and vitamins without clogging your pores.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/), [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a great fit for acne-prone skin because it uses retinol to help clear pores by speeding up cell turnover, along with bisabolol to calm the skin. Squalane and tocopheryl acetate also help smooth the skin while keeping it comfortable.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/), [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/)

### What does Microencapsulated Retinol do for acne-prone skin?

Microencapsulated Retinol is a great fit for acne-prone skin because it helps clear blemishes and smooth uneven texture while being gentle on the skin. This type of product delivers steady results with a lower chance of irritation and redness.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2020](https://pubmed.ncbi.nlm.nih.gov/32869963/), [Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/)

### What does Vitamin C do for acne-prone skin?

Vitamin C helps protect acne-prone skin and calm redness while working to fade dark spots left behind by breakouts. It is unlikely to cause irritation and may improve overall skin tone when used consistently in your routine.
Sources: [Giornale Italiano Di Dermatologia E Venereologia, 2014](https://pubmed.ncbi.nlm.nih.gov/25068233/), [Journal of Drugs in Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/39231081/)

### Where does this serum go in a skincare routine for acne-prone skin?

This serum goes in the evening routine after cleansing and before moisturizing. Putting it at night helps avoid extra sun sensitivity while clearing blemishes and smoothing the skin.

### Can I use this serum with niacinamide, and in what order?

Yes, you can use this serum with niacinamide by applying niacinamide first and letting it absorb before putting on this treatment. Using them together helps clear blemishes and keep skin calm, as the soothing components in this serum keep irritation unlikely.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/)

### How often should I use this serum?

Peter Thomas Roth Retinol Fusion PM Night Serum is a great fit for your acne-prone skin and is used in the evening as part of your nightly routine. This timing keeps your skin safe around sun exposure, and the soothing ingredients help prevent irritation while clearing blemishes.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is a great fit and is unlikely to clog pores or cause breakouts because it leaves out harsh ingredients and includes soothing components. It uses retinol to help clear blemishes by speeding up cell turnover, though you may notice some initial purging as your skin adjusts.
Sources: [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/), [International Journal of Toxicology, 2011](https://pubmed.ncbi.nlm.nih.gov/22247236/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol).

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — €10.20 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €35.80 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/nl/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/acne-prone-skin) — Superior fit — €99.41 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/nl/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €19.20 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Cyclopentasiloxane, Squalane, Water, Retinol, Tocopheryl Acetate, Ascorbyl Palmitate, Bisabolol, Lecithin, Potassium Phosphate, Pentylene Glycol, Polysorbate-20, Alcohol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/acne-prone-skin
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- Italy: https://lovi.care/skincare/it/p/peter-thomas-roth/retinol-fusion-pm-night-serum/for/acne-prone-skin
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