Peter Thomas Roth PEPTIDE SKINJECTION for acne-prone skin
Glycerin
Tetrapeptide-1
Hyaluronic Acid
Average
- HighCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for acne-prone skin; other moisturizers fit it better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate hydration for your combination skin, with glycerin and hyaluronic acid providing excellent moisturizing effects and niacinamide helping to regulate oil production.
- While the formula is generally safe and beneficial for combination skin, its primary focus on hydration and soothing from ingredients like allantoin does not directly address your concerns with acne, blemishes, and breakouts.
- The product is safe for your combination skin, containing no harsh or prohibited ingredients that would cause irritation.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
People Say
★4.6Overall rating based on 200+ reviewsThis product line is highly praised for its effectiveness in softening fine lines and improving skin texture, with many users reporting smoother and more hydrated skin. Some users have noted a gritty texture in the serum and varying results for deep wrinkle reduction.
Highlights
Reduces fine lines Mostly Mentioned
- “Big change in forehead lines”
- “lines around eyes decreased”
- “definite reduction in lines”
Smooths skin texture Often Mentioned
- “Skin has never felt so smooth”
- “makeup goes on smooth”
- “melts into my skin”
Hydrating formula Sometimes Noted
- “Thick hydrating feel”
- “skin feels more hydrated”
- “helps hydrate”
Reduces eye puffiness Sometimes Noted
- “Less puffiness under eyes”
- “quick relief of puffiness”
- “noticed less puffiness”
Gritty serum texture Sometimes Noted
- “Lotion has a little grit”
- “texture is a little gritty”
- “creamy and a bit gritty”
High price point Sometimes Noted
- “hefty price”
- “less hefty price”
Drying sensation Rarely Noted
- “A bit drying”
- “skin did not feel oily”
Slow/No results Rarely Noted
- “Not noticed any reduction”
- “only been 12 days”
- “didn't last a week”
Sources: lovi.care, peterthomasroth.com, lovelyskin.com, dermstore.com, reddit.com, and more
Questions and answers
How well does Peter Thomas Roth Peptide Skinjection work for acne-prone skin?
This treatment works reasonably well for acne-prone skin, offering moderate moisture and soothing benefits with glycerin and hyaluronic acid, though it lacks targeted blemish-fighting ingredients. A moisturizing treatment for acne-prone skin needs ingredients like niacinamide and targeted blemish-fighting components that help clear breakouts while providing balanced hydration.
Which ingredients make this cream a good fit for acne-prone skin?
Glycerin, hyaluronic acid, and niacinamide help make this cream a good fit by providing balanced moisture and helping to regulate oil production. To work best for acne-prone skin, a product of this type needs ingredients that directly target breakouts and blemishes while keeping skin calm.
What does Glycerin do for acne-prone skin?
Glycerin helps keep acne-prone skin hydrated and calm without clogging pores or feeling heavy. It supports the skin barrier so it stays soft and smooth while handling everyday treatments.
The British Journal of Dermatology, 2008International Journal of Toxicology, 2019
What does Tetrapeptide-1 do for acne-prone skin?
Tetrapeptide-1 helps calm acne-prone skin by reducing redness and soothing irritated areas. Peptides of this type support the skin barrier and may help manage breakouts when combined with a gentle daily routine.
Where does this cream go in a skincare routine for acne-prone skin?
This moisturizing treatment goes in the evening routine after cleansing and a cleansing toner, followed by a moisturizer. Acne-prone skin needs a product of this type to include targeted blemish-fighting ingredients and oil-regulating actives like niacinamide.
Can I use this cream with retinol, and in what order?
You can use this moisturizing treatment with retinol by applying the cream first to keep your skin soft and smooth, then following with retinol. Using a moisturizer alongside retinol helps reduce dryness and irritation while supporting your skin barrier.
How often should I use this cream?
You can use this moisturizing treatment twice daily as part of your routine. Daily application helps improve skin moisture and supports the skin barrier.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can this cream clog pores, cause breakouts or purging for acne-prone skin?
This moisturizing treatment is unlikely to clog pores or cause breakouts on acne-prone skin, as it contains no harsh or irritating ingredients. However, because its primary focus is on hydration and soothing rather than treating blemishes, acne-prone skin needs products with ingredients like salicylic acid or benzoyl peroxide to directly clear pores and control breakouts.
Can I use this cream around the eyes or on my body?
You can use this moisturizing treatment safely on your body and around your eyes since the formula is generally safe and contains no harsh or prohibited ingredients that would cause irritation. The thin skin around the eyes and the skin on the body benefit from gentle hydration, but remember that the eyelids and inguinal areas are among the thinnest body regions and require careful application.
Is this cream fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel.
Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.
Journal of Cosmetic Dermatology, 2020Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.
International Journal of Cosmetic Science, 2001Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.
Journal of Drugs in Dermatology, 2012Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019
Why other moisturizers fit acne-prone skin better
Gluconolactone 14% solution significantly improved mild to moderate acne by reducing inflamed and non-inflamed lesions similarly to 5% benzoyl peroxide, but with fewer side-effects in 150 patients.
The Australasian Journal of Dermatology, 1992A Tris/Arg-formulated cleanser significantly decreased noninflammatory and inflammatory acne and pore size with keratotic plugs compared to an AEC/AC cleanser in male Thai subjects with mild to moderate acne over 4 weeks.
Journal of Cosmetic Dermatology, 2020Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.
Molecules, 2023
Ingredients
Water, Glycerin, Chondrus Crispus Powder, Butylene Glycol, Tetrapeptide-1, Hyaluronic Acid, Allantoin, Trehalose, Caffeine, Squalane, Niacinamide, Adenosine, Tocopheryl Acetate, Calcium Lactate, Opuntia Ficus-Indica Flower Extract, Chondrus Crispus Extract, Chlorphenesin, Ricinus Communis Seed Oil Castor Seed Oil, Potassium Chloride, Dextrin, Sodium Phytate, Caprylyl Glycol, Citric Acid, Ceratonia Siliqua Gum, Xanthan Gum, Peg-60 Hydrogenated Castor Oil, Ultramarines, Chromium Hydroxide Green Ci 77289, Phenoxyethanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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