# Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Perricone MD](https://lovi.care/skincare/nl/brands/perricone-md)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/nl/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few moisturizers fit it even better.

## Why this fit

- Excellent suitability for your normal skin is provided by niacinamide and S-Palmitoylglutathione, which work to repair your skin barrier and offer antioxidant protection, respectively.
- The formula also addresses your concerns about wrinkles and fine lines with Palmitoyl Glycine, supporting anti-aging benefits.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like Niacinamide and Shea Butter.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, Niacinamide, Shea Butter, Lactic Acid, Vitamin F Blend

## What the research says

- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Palmitoyl glycine and cocoyl alanine demonstrated complementary anti-aging properties and superior anti-wrinkle efficacy compared to a market reference ingredient in Caucasian women. ([International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/19732187/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39528438/))
- Application of a cream containing lactic acid 12% and pramoxine HCl 1% significantly improved skin dryness, hydration, and itch compared with a nontreated control in 24 women with a history of dry itchy skin. ([Cutis, 2004](https://pubmed.ncbi.nlm.nih.gov/15027519/))
- Topical 12% ammonium lactate produced a significant sparing of epidermal and dermal atrophy induced by clobetasol propionate in human volunteers, without influencing the corticosteroid's bioavailability or antiinflammatory properties. ([Journal of the American Academy of Dermatology, 1992](https://pubmed.ncbi.nlm.nih.gov/1597538/))
- A lactic acid/ceramide lotion significantly improved skin moisturization and desquamation compared to no treatment in women with dry, rough skin on the anterior shins. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/33178384/))
- Topical application of linoleic acid achieved an almost 25% reduction in the overall size of follicular casts and microcomedones over a 1-month treatment period in patients with mild acne compared to no change at placebo-treated sites. ([Clinical and Experimental Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9692305/))
- Topical conjugated linolenic acid significantly reduced edema on post-procedure Day 3 and itching on Days 1 and 3, and improved wrinkling at Day 14 compared to 1% dimethicone ointment in 34 subjects undergoing fractionated CO2 laser resurfacing of the face. ([The Journal of Clinical and Aesthetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/29344315/))
- Liposomal formulation of linoleic acid significantly enhances its skin whitening effect compared to non-liposomal forms in UV-stimulated guinea pig and human skin. ([Biological & Pharmaceutical Bulletin, 2004](https://pubmed.ncbi.nlm.nih.gov/15056874/))

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Perricone MD Intensive Overnight Moisturizer a great fit for mature skin?

Perricone MD Essential Fx Acyl-Glutathione Intensive Overnight Moisturizer is a great fit for mature skin because it contains niacinamide and S-Palmitoylglutathione to repair your skin barrier and protect against damage, while Palmitoyl Glycine smooths out wrinkles and fine lines. It also has a very safe profile with soothing ingredients like shea butter that make irritation unlikely.
Sources: [International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/19732187/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### Which ingredients make this cream a good fit for mature skin?

This cream is a great fit for mature skin because it includes Palmitoyl Glycine to smooth out wrinkles and fine lines, along with niacinamide and S-Palmitoylglutathione to protect against everyday damage and repair the skin barrier. It also features soothing shea butter to keep your skin feeling soft and calm with virtually no risk of irritation.
Sources: [International Journal of Cosmetic Science, 2010](https://pubmed.ncbi.nlm.nih.gov/19732187/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### What does Acyl-Glutathione do for mature skin?

Acyl-Glutathione helps mature skin by smoothing fine wrinkles and keeping the skin hydrated while providing strong antioxidant protection. Topical application of glutathione-based products is safe and may improve skin quality and brightness.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/), [Giornale Italiano Di Dermatologia E Venereologia, 2019](https://pubmed.ncbi.nlm.nih.gov/28399620/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this cream go in a skincare routine for mature skin?

This moisturizing treatment goes in the evening routine after cleansing and a cleansing toner, followed by a moisturizer. It helps smooth mature skin by combining barrier-repairing niacinamide with anti-aging ingredients.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying the retinol first at night, followed by this moisturizer to help keep your skin calm and hydrated. Because it contains soothing ingredients like niacinamide and shea butter, it is unlikely to cause irritation while supporting your routine.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### How often should I use this cream?

You can use this moisturizing treatment in the evening as part of your routine for mature skin. Daily application helps improve fine lines, wrinkles, and skin moisture while supporting your skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This moisturizing treatment is unlikely to clog pores or cause breakouts for mature skin, as it has a very safe profile without harsh ingredients. It also features soothing components like niacinamide and shea butter that help keep skin calm.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Can I use this cream around the eyes or on my body?

This cream is well suited for the face, but its rich moisturizing treatment style is generally intended for facial use rather than the thin skin around the eyes or broader body areas. When applying potent anti-aging ingredients near sensitive zones, it is best to check for specific eye-safe testing or use dedicated body lotions to prevent heavy buildup.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool).

## Alternatives for mature skin

- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/nl/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — €69.99 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/nl/p/the-ordinary/natural-moisturizing-factors-ha/for/mature-skin) — High fit — €13.02 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Cream](https://lovi.care/skincare/nl/p/missha/super-aqua-ultra-hyalron-cream/for/mature-skin) — High fit — €39.42 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- SPF: [SKIN1004 MADAGASCAR CENTELLA AIR-FIT SUNCREAM PLUS](https://lovi.care/skincare/nl/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/mature-skin) — Superior fit — €14.70 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Butyrospermum Parkii Butter Shea Butter, Myristyl Myristate, Niacinamide, C12-15 Alkyl Benzoate, Stearic Acid, Dimethicone, Sodium Acrylates Copolymer, Palmitoyl Glycine, S-Palmitoylglutathione, Ethylhexylglycerin, Myristyl Laurate, Ribose, Lecithin, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Salvia Hispanica Seed Oil, Magnesium Aspartate, Zinc Gluconate, Copper Gluconate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Glyceryl Stearate, Peg-100 Stearate, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/mature-skin
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- Italy: https://lovi.care/skincare/it/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/perricone-md/essential-fx-acyl-glutathione-intensive-overnight-moisturizer/for/mature-skin
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