# Perricone MD Deep Crease Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Perricone MD](https://lovi.care/skincare/nl/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Offers high compatibility with normal skin due to S-Palmitoylglutathione and Tetrahexyldecyl Ascorbate, which provide antioxidant benefits and support collagen synthesis for wrinkle reduction.
- The inclusion of Palmitoyl Tripeptide-5 and Acetyl Hexapeptide-8 effectively addresses fine lines and wrinkles by promoting plumping and smoothing.
- The product is safe for your skin, with no risk of irritation from harsh ingredients and the presence of soothing agents like Rosemary Leaf Extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Acyl-Glutathione, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8

## What the research says

- A 3-in-1 anti-aging topical night serum-in-oil applied once daily decreased wrinkles by 11%, increased skin firmness by 8%, reduced redness by 70%, and improved overall skin quality and complexion in 103 female subjects over 28 to 84 days compared to baseline. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30924254/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))

## What reviewers say

Users in their 40s and 50s frequently praise this serum for its lightweight, non-greasy feel and its ability to hydrate and soften the appearance of expression lines. While results are gradual, consistent use leads to firmer, smoother-looking skin.

- Liked: Lightweight texture (mostly mentioned)
- Liked: Hydrating formula (often mentioned)
- Liked: Softens deep lines (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Improves firmness (sometimes noted)
- Disliked: Dropper issues (sometimes noted)
- Disliked: Gradual results (sometimes noted)
- Disliked: Fragrance sensitivity (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Perricone MD Deep Crease Serum a great fit for mature skin?

This serum is a great fit for mature skin because its blend of peptides and vitamin C helps smooth fine lines, boost collagen, and keep skin looking firm and soft. It is very safe and gentle to use daily, working to reduce deep wrinkles while keeping skin calm and comfortable.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because it contains S-Palmitoylglutathione and Tetrahexyldecyl Ascorbate, which provide antioxidant benefits and support collagen synthesis. Additionally, the inclusion of Palmitoyl Tripeptide-5 and Acetyl Hexapeptide-8 helps smooth and plump lines and wrinkles.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### What does Acyl-Glutathione do for mature skin?

Acyl-Glutathione helps mature skin by smoothing fine wrinkles and keeping the skin hydrated while providing strong antioxidant protection. Topical application of glutathione-based products is safe and may improve skin quality and brightness.
Sources: [The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/), [Giornale Italiano Di Dermatologia E Venereologia, 2019](https://pubmed.ncbi.nlm.nih.gov/28399620/)

### What does Palmitoyl Glutathione do for mature skin?

Palmitoyl glutathione helps protect mature skin against environmental stress and damage by increasing cellular glutathione levels. This helps keep skin looking healthy, but this type of product also needs ingredients like retinoids or peptides to properly smooth fine lines and firm sagging areas.
Sources: [Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/)

### Where does it go in a skincare routine for mature skin?

This treatment goes in your evening routine, applied after cleansing and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying your retinol in your evening routine and using this serum on alternating nights to keep your skin calm. This helps you avoid potential irritation while still addressing fine lines and wrinkles. It is unlikely to cause discomfort, as it is formulated with soothing agents like rosemary leaf extract.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### How often should I use this serum?

Use this serum in your evening routine, as treatments fit best there for simplicity and extra safety around sun exposure. Applying it daily may help smooth fine lines and wrinkles while keeping your skin looking plump.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Can it clog pores, cause breakouts or purging for mature skin?

Perricone MD Deep Crease Serum is unlikely to clog pores or cause breakouts for mature skin. It features a gentle formulation designed to smooth and firm without harsh ingredients that typically trigger irritation or congestion.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, citronellol, limonene, and linalool).

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €160.00 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €35.50 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/nl/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — €419.00 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/nl/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €48.84 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Squalane, Hydrogenated Polyisobutene, S-Palmitoylglutathione, Dimethicone, Glycerin, Macadamia Ternifolia Seed Oil, Xylitylglucoside, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Palmitoyl Tripeptide-5, Acetyl Hexapeptide-8, Anhydroxylitol, Lactic Acid, Xylitol, Xanthan Gum, Linum Usitatissimum Seed Oil, Salvia Hispanica Seed Oil, Tocopherol, Ethylhexylglycerin, Magnesium Aspartate, Zinc Gluconate, Alaria Esculenta Extract, Glucose, Sodium Hyaluronate, Copper Gluconate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Palmitoyl Dipeptide-5 Diaminobutyroyl Hydroxythreonine, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Magnesium Chloride, Caprylic Capric Triglyceride, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Caprylyl Capryl Glucoside, Caprylyl Glycol, Potassium Sorbate, Phenoxyethanol, Parfum, Citronellol, Hydroxycitronellal, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/deep-crease-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/deep-crease-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/deep-crease-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/deep-crease-serum/for/mature-skin
- France: https://lovi.care/skincare/fr/p/perricone-md/deep-crease-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/deep-crease-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/deep-crease-serum/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/perricone-md/deep-crease-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/deep-crease-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/deep-crease-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/deep-crease-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/deep-crease-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/deep-crease-serum/for/mature-skin