# Paula's Choice PRO Retinaldehyde Dual-Retinoid Treatment for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/nl/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Paula's Choice](https://lovi.care/skincare/nl/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers excellent anti-aging and acne benefits for your oily skin, as retinaldehyde and retinol promote skin renewal and regulate oil production, while niacinamide further aids in seboregulation.
- The inclusion of hyaluronic acid and panthenol provides essential hydration and soothing effects, enhancing overall skin comfort.
- This formula is safe for your skin, with no identified risks of irritation due to the absence of harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/nl/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Retinaldehyde, Retinol, Niacinamide, Hyaluronic Acid, Squalane

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Twice daily application of retinaldehyde 0.1% and 0.05% creams for 3 months improved skin texture and hydration and reduced transepidermal water loss in 40 female Korean volunteers, with only the 0.1% cream significantly improving the melanin index. ([Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29663701/))
- Topical retinaldehyde demonstrated significant antibacterial activity against gram-positive bacteria both in vitro and in vivo, leading to decreased bacterial counts without inducing resistance. ([Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12218231/))
- Topical 0.05% retinaldehyde applied over 1 year significantly increased epidermal thickness of the temple and cutaneous elasticity compared to an emollient control group in 40 aging skin patients. ([Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10473959/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Users with acne-prone and aging skin report significant improvements in skin clarity and texture, often describing the product as a "game changer" for stubborn breakouts and fine lines. While the dual-retinoid formula is praised for being surprisingly gentle and effective where other retinols failed, some users experienced an initial purging phase and noted the bright yellow formula can stain fabrics.

- Liked: Clears acne (mostly mentioned)
- Liked: Gentle formula (often mentioned)
- Liked: Smoothes texture (often mentioned)
- Liked: Pleasant texture (sometimes noted)
- Disliked: Initial purging phase (sometimes noted)
- Disliked: Stains fabric yellow (sometimes noted)
- Disliked: High price point (rarely noted)
- Disliked: Slow to show results (rarely noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Paula's Choice PRO Retinaldehyde Dual-Retinoid Treatment a great fit for oily acne-prone skin?

This treatment is a great fit because retinaldehyde and retinol help renew your skin and manage oil, while niacinamide helps balance oil further. Hyaluronic acid and panthenol also bring gentle moisture and comfort, keeping your oily acne-prone skin calm and soft.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Which ingredients make this treatment a good fit for oily acne-prone skin?

This treatment is a great fit for your oily acne-prone skin because retinaldehyde and retinol help renew the skin and control oil, while niacinamide further helps balance oil production. Additionally, hyaluronic acid and panthenol provide much-needed hydration and soothing comfort without causing irritation.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### What does Retinal do for oily acne-prone skin?

Retinal helps clear clogged pores, reduces bumps and pimples, and helps balance oil production for oily, acne-prone skin. It is generally well tolerated when used regularly as part of an acne skincare routine.
Sources: [Clinical and Experimental Dermatology, 1999](https://pubmed.ncbi.nlm.nih.gov/10564319/), [European Review for Medical and Pharmacological Sciences, 2014](https://pubmed.ncbi.nlm.nih.gov/25219827/)

### What does Retinol do for oily acne-prone skin?

Retinol helps oily acne-prone skin by clearing up breakouts and smoothing the skin, though it may occasionally cause some mild scaling or stinging. This ingredient works by addressing the root causes of acne, making it a reliable choice for keeping pores clear and skin smooth.
Sources: [American Journal of Clinical Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30674002/), [Journal of Drugs in Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/30586483/)

### Where does this treatment go in a skincare routine for oily acne-prone skin?

This treatment goes in the evening routine. It is a great fit for your oily acne-prone skin because the retinaldehyde and retinol renew your skin and manage oil, while niacinamide helps control oil further.
Sources: [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this treatment with vitamin C, and in what order?

You can use this treatment with vitamin C, but it is best to apply vitamin C in the morning and this treatment at night to avoid any potential irritation. Using them at different times of day helps your skin stay calm while still getting all the anti-aging and oil-balancing benefits.

### How often should I use this treatment?

This treatment is a great fit for your oily acne-prone skin, offering acne and anti-aging benefits while helping control oil and keeping skin calm. You can use it in your evening routine, starting just once a week and slowly using it more often if your skin handles it well.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38406974/), [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36798538/)

### Can this treatment clog pores, cause breakouts or purging for oily acne-prone skin?

This treatment may cause a temporary purging phase as the retinoids promote skin renewal and help clear your oily skin. However, it is otherwise a great fit that regulates oil and is unlikely to cause irritation.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for oily acne-prone skin

- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/nl/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/oily-acne-prone-skin) — Superior fit — €99.41 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — €10.20 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — €35.50 at Amazon

## Pairs well with

- Cleanser: [Paula's Choice CLEAR Pore Normalizing Cleanser](https://lovi.care/skincare/nl/p/paula-s-choice/clear-pore-normalizing-cleanser/for/oily-acne-prone-skin) — Superior fit — €29.00 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/nl/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/oily-acne-prone-skin) — Superior fit — €19.20 at Amazon

## Where to buy

- Amazon.nl: €75.00 (https://www.amazon.nl/dp/B0DCVTQ4XV?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Cetearyl Alcohol, Retinaldehyde, Retinol, Caprylic Capric Triglyceride, Squalane, Butyrospermum Parkii Butter Shea Butter, Niacinamide, Tocopherol Vitamin E, Panthenol, Hyaluronic Acid, Allantoin, Bisabolol, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Camellia Sinensis Leaf Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Aloe Barbadensis Leaf Juice, Xanthan Gum, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin (this page)
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/pro-retinaldehyde-dual-retinoid-treatment/for/oily-acne-prone-skin