# Paula's Choice 25% Vitamin C + Glutathione Clinical Serum for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Paula's Choice](https://lovi.care/skincare/nl/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, the tetrahexyldecyl ascorbate and ascorbic acid offer antioxidant activity and support collagen synthesis, addressing your oily shine. Ascorbyl glucoside and glutathione provide excellent brightening and evening of skin tone, further complementing your skin concerns.
- The formula is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
- This serum offers relevant skincare benefits for oily shine and combination skin due to the presence of tetrahexyldecyl ascorbate and ascorbyl glucoside in concentrations that provide antioxidant and brightening effects.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Ascorbic Acid, Glutathione, Ergothioneine, Ascorbyl Glucoside, Tocopherol

## What the research says

- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation. ([American Journal of Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/15862509/))
- A targeted skincare regimen containing active ingredients such as rhodophyceae extract, ergothioneine, and L-carnosine significantly reduced transepidermal water loss by 24.09%, improved skin elasticity, and decreased redness, dryness, and desquamation in thirty-five female Chinese participants over 4 weeks following advanced optimal pulse technology treatment. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40497421/))
- A triple combination of ergothioneine, collagen peptides, and sodium hyaluronate attenuated UV-induced skin damage ex vivo and improved facial skin hydration, elasticity, barrier function, and wrinkles in Chinese women. ([Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/))
- Ergothioneine at nanomolar concentrations ameliorated UVA-induced skin damage, reactive oxygen species, and apoptosis in human keratinocyte-derived HaCaT cells by upregulating Nrf2/ARE-mediated antioxidant genes. ([Free Radical Biology & Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26021820/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))

## What reviewers say

Many reviewers report a noticeable glow, improved skin bounce, and the fading of stubborn sun spots and post-inflammatory hyperpigmentation after consistent use.

- Liked: Gentle & non-irritating (mostly mentioned)
- Liked: Effective brightening (often mentioned)
- Liked: Elegant texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Heavy for oily (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Paula's Choice 25% Vitamin C + Glutathione Clinical Serum a great fit for combination skin?

This serum is a great fit because its blend of vitamin C and glutathione brightens uneven skin tone and fights oily shine. It is safe for your skin with no harsh ingredients, and helps support firmness while keeping your face smooth.
Sources: [Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/), [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### Which ingredients make this serum a good fit for combination skin?

This serum is a great fit for your combination skin because ascorbic acid, tetrahexyldecyl ascorbate, and ascorbyl glucoside help brighten your skin tone and manage oily shine. Glutathione adds further brightening benefits and helps keep your skin smooth and even.
Sources: [Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/), [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### What does Vitamin C do for combination skin?

Vitamin C helps brighten dull areas and smooth out uneven texture on combination skin while protecting against daily environmental stress. It may also help keep pores clear and skin firm by supporting collagen production, though drier spots may need an added moisturizer to stay comfortable.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/)

### What does Glutathione do for combination skin?

Glutathione helps brighten sun-exposed areas and reduce dark spots for combination skin, while also improving moisture and smoothness. It is unlikely to cause irritation and maintains a safe profile for regular use.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [International Journal of Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39444151/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in the evening routine after cleansing and before moisturizing, which keeps things simple and provides extra safety around sun exposure. Some serums of this type can also be used in the morning or twice a day depending on personal preference and skin tolerance.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying them on alternate nights or using this vitamin C in the morning and retinol at night to keep your skin calm and smooth. This approach is unlikely to cause irritation while helping manage oily shine and uneven skin tone.
Sources: [Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/), [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### How often should I use this serum?

This serum fits your combination skin very well and is used in the evening routine, while some people also use it in the morning or twice a day. The formula is very safe for your skin, with no risk of irritation since it lacks harsh ingredients, and antioxidants like Ascorbic Acid help brighten your skin tone and manage oily shine.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/), [Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause breakouts or clog pores for your combination skin. The formula is safe and gentle, with a low risk of irritation and no heavy ingredients that typically bother this skin type.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — €10.20 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €35.80 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/nl/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €474.90 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/nl/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €16.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/nl/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/combination-skin) — Superior fit — €19.20 at Amazon

## Where to buy

- Amazon.nl: €73.00 (https://www.amazon.nl/dp/B0CZ4BKT3T?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
Prices checked 5 Nov 2026.

## Ingredients

Water, Tetrahexyldecyl Ascorbate, Dimethicone, Glycerin, C9-12 Alkane, Ascorbyl Glucoside, Silica, Pyrus Malus Fruit Extract, Hydrogenated Lecithin, Polyglyceryl-6 Polyricinoleate, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Rice Bran Extract, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Caprylyl Glycol, Lysine Carboxymethyl Cysteinate, Coco Caprylate Caprate, Tocopherol, Glutathione, Sodium Citrate, Sodium Phytate, Hexylene Glycol, Ethylhexylglycerin, Helianthus Annuus Seed Extract Sunflower Seed Extract, Urea, Mannitol, Caprylic Capric Triglyceride, Sodium Pca, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Polysorbate 60, Sorbitan Isostearate, Trehalose, Ascorbic Acid, Glucose, Vanilla Planifolia Fruit Extract, Polyquaternium-51, Ergothioneine, Triacetin, Sodium Hyaluronate, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin
- France: https://lovi.care/skincare/fr/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin (this page)
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin