OSEA Seabiotic Water Cream for skin with dark spots

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• Fucoxanthin exerted protective and therapeutic effects against UV-induced sunburn and filaggrin downregulation by promoting skin barrier formation through filaggrin induction.

  Journal of Pharmacological Sciences, 2016

• Topical application of 0.5% fucoxanthin dissolved in alkyl benzoate or ethanol did not decrease reconstructed human skin viability below 50%, while reducing pro-inflammatory interleukins 6 and 8 and increasing NAT1 gene expression compared to ethanol alone.

  Pharmaceutics, 2020

• The combination of 5 µM rosmarinic acid and 5 µM fucoxanthin exerted photo-protective and anti-inflammatory effects in UVB-irradiated HaCaT keratinocytes by reducing apoptosis and ROS production, down-regulating NLRP3 inflammasome components, and increasing Nrf2 and HO-1 expression compared to individual compounds.

  Marine Drugs, 2019

• Snow mushroom alcohol-based hand rub gel significantly improved skin moisture better than the placebo through 180 minutes while maintaining comparable antiseptic efficacy in 20 human volunteers.

  Journal of Cosmetic Dermatology, 2021

• Tremella fuciformis extract demonstrates potential cutaneous benefits including skin antiaging, photoprotection, wound healing, and barrier protection based on in vitro and animal models.

  Archives of Dermatological Research, 2023

• Tremella fuciformis inhibits melanogenesis by decreasing melanin content and tyrosinase expression in B16F10 cells while promoting wound healing in human HaCaT keratinocytes and Detroit 551 fibroblasts.

  In Vivo, 2022

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

• Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects.

  Journal of Drugs in Dermatology, 2012

Why other moisturizers fit skin with dark spots better

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2014

Ingredients

Water, Glycerin, Caprylic Capric Triglyceride, Squalane, Isoamyl Laurate, Undecane, Cetearyl Alcohol, Hectorite, Cetearyl Olivate, Sorbitan Olivate, Glyceryl Caprylate, Undaria Pinnatifida Extract, Tremella Fuciformis Polysaccharide, Sodium Hyaluronate, Betulin, Tocopherol, Pavlova Lutheri Extract, Terminalia Ferdinandiana Fruit Extract, Laminaria Ochroleuca Extract, Bisabolol, Calendula Officinalis Flower Extract, Brassica Oleracea Italica Extract, Zingiber Officinale Root Extract, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Corallina Officinalis Extract, Coccinia Indica Fruit Extract, Solanum Melongena Fruit Extract, Aloe Barbadensis Flower Extract, Ocimum Sanctum Leaf Extract, Ocimum Basilicum Leaf Extract Flower, Curcuma Longa Root Extract, Caesalpinia Spinosa Pod Extract Fruit, Helianthus Annuus Extract Sprout Sunflower Extract Sprout, Maltodextrin, Fucus Vesiculosus Extract, Lactobacillus Ferment, Tridecane, Sodium Stearoyl Glutamate, Caprylhydroxamic Acid, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Citric Acid, Sodium Benzoate, Potassium Sorbate, Phenoxyethanol, Caprylyl Glycol, Ethylhexylglycerin, Hexylene Glycol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.