# Neutrogena Stubborn Marks PM Treatment for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Neutrogena](https://lovi.care/skincare/nl/brands/neutrogena)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for wrinkles and fine lines due to the presence of retinol and ascorbic acid, which promote skin renewal and collagen production, making it suitable for your normal skin.
- Sodium hyaluronate and BHT further support skin hydration and provide antioxidant protection, enhancing the overall efficacy for your primary goal.
- The product is safe for your normal skin, as it contains soothing ingredients and lacks harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/oily-acne-prone-skin): High

## Key ingredients

Retinol Sa, Ascorbic Acid, Sodium Hyaluronate, Glycerin, Hydrolyzed Myrtus Communis Leaf Extract

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Optimized transfersomes loaded with epigallocatechin-3-gallate and hyaluronic acid increased cell viability while reducing lipid peroxidation, intracellular ROS, and MMP expression in HaCaT cells, and exhibited higher skin permeation and deposition compared to plain EGCG. ([Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- Topical treatments including podophyllotoxin, sodium nitrite, myrtle leaf extract, phenol, salicylic acid with lactic acid, SB206, and VP-102 were more efficacious than control in patients with molluscum contagiosum, whereas cantharidin, potassium hydroxide, and imiquimod showed varying degrees of efficacy. ([Clinics in Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34920817/))
- Topical Myrtle solution significantly reduced inflammatory lesions and acne severity index compared to 1% clindamycin solution in patients with mild to moderate acne vulgaris. ([Journal of Pharmacopuncture, 2020](https://pubmed.ncbi.nlm.nih.gov/33408898/))

## What reviewers say

Users with acne-prone skin report that this treatment effectively fades post-inflammatory hyperpigmentation and dark spots, often showing visible results within a few weeks. While many praise its ability to smooth skin texture and even out tone, a significant number of users experience initial dryness, flaking, or stinging as their skin adjusts to the retinol formula.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: Small quantity (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Prevents breakouts (sometimes noted)
- Disliked: Drying and irritation (sometimes noted)
- Disliked: Ineffective on wrinkles (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Neutrogena Stubborn Marks work for mature skin?

Neutrogena Stubborn Marks PM Treatment works moderately well for mature skin, offering helpful benefits for fine lines and wrinkles through retinol and vitamin C. However, this skin type generally needs a treatment that combines exceptionally safe, high concentrations of potent antioxidants and hydrating ingredients to deliver optimal anti-aging results without any irritation.

### Which ingredients make this treatment a good fit for mature skin?

Retinol SA and ascorbic acid make this treatment a good fit for mature skin by helping smooth out fine lines and supporting firmness. For this skin type, a product needs a higher concentration of potent anti-aging ingredients, rich antioxidants, and extra hydrating components to deliver optimal results.

### What does Retinol SA do for mature skin?

Retinol SA helps smooth out fine lines and wrinkles on mature skin while improving overall firmness and texture. It promotes skin renewal to refresh tired-looking areas, though it may occasionally cause mild dryness or irritation when you first start using it.
Sources: [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39128883/), [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20633013/)

### What does Vitamin C do for mature skin?

Vitamin C helps mature skin by smoothing out wrinkles, brightening dark spots, and boosting firmness. It works by encouraging collagen production to keep skin looking youthful and radiant.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### Where does this treatment go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before moisturizing. To best care for mature skin, a product of this type needs powerful antioxidants, collagen-boosting ingredients like retinol or vitamin C, and deep hydrators like hyaluronic acid and glycerin to smooth fine lines and keep the skin soft.

### Can I use this treatment with benzoyl peroxide, and in what order?

It is best to use benzoyl peroxide and this treatment at different times of the day, or alternate nights, to help prevent dryness and irritation on mature skin. Applying a retinol treatment at night and benzoyl peroxide at another time helps protect your skin barrier while keeping your routine effective.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this treatment?

You can use this treatment in the evening as part of your routine. Because this product is an average fit for mature skin, a routine for this skin needs nourishing antioxidants, hydrating ingredients like sodium hyaluronate and glycerin, and effective retinols to properly support aging skin.
Sources: [Facial Plastic Surgery, 2014](https://pubmed.ncbi.nlm.nih.gov/24488631/)

### Can this treatment clog pores, cause breakouts or purging for mature skin?

This treatment is unlikely to clog pores or cause breakouts for mature skin, but it may cause mild drying and irritation at first. To better support mature skin, products of this type need extra nourishing oils and richer hydrators to keep the face soft and smooth while smoothing lines.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Stearyl alcohol and cetearyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €160.00 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €35.50 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/nl/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — €419.00 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/nl/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €48.84 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentaerythrityl Tetraethylhexanoate, Dimethicone, Glycerin, Ppg-15 Stearyl Ether, Stearyl Alcohol, Cetearyl Alcohol, Butylene Glycol, Ceteareth-20, Isohexadecane, Dimethicone Crosspolymer, Trisiloxane, Phenoxyethanol, Caprylyl Glycol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Polyacrylamide, C13-14 Isoparaffin, Chlorphenesin, Hydrolyzed Myrtus Communis Leaf Extract, Polysorbate 20, Bht, Retinol, Disodium Edta, Sodium Hyaluronate, Ascorbic Acid, Laureth-7, Sodium Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin
- France: https://lovi.care/skincare/fr/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin