# Neutrogena Stubborn Marks PM Treatment for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Neutrogena](https://lovi.care/skincare/nl/brands/neutrogena)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for skin with dark spots.

## Why this fit

- Offers excellent treatment for minimizing fine lines and wrinkles, and pigmentation concerns for your normal skin due to the presence of retinol and ascorbic acid, which promote skin renewal and brightening while plumping and smoothing texture.
- Sodium hyaluronate further supports collagen synthesis and hydration, enhancing the overall efficacy for your skin.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/oily-acne-prone-skin): High

## Key ingredients

Retinol Sa, Ascorbic Acid, Sodium Hyaluronate, Glycerin, Hydrolyzed Myrtus Communis Leaf Extract

## What the research says

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- Topical treatments including podophyllotoxin, sodium nitrite, myrtle leaf extract, phenol, salicylic acid with lactic acid, SB206, and VP-102 were more efficacious than control in patients with molluscum contagiosum, whereas cantharidin, potassium hydroxide, and imiquimod showed varying degrees of efficacy. ([Clinics in Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34920817/))
- Topical Myrtle solution significantly reduced inflammatory lesions and acne severity index compared to 1% clindamycin solution in patients with mild to moderate acne vulgaris. ([Journal of Pharmacopuncture, 2020](https://pubmed.ncbi.nlm.nih.gov/33408898/))

## What reviewers say

Users with acne-prone skin report that this treatment effectively fades post-inflammatory hyperpigmentation and dark spots, often showing visible results within a few weeks. While many praise its ability to smooth skin texture and even out tone, a significant number of users experience initial dryness, flaking, or stinging as their skin adjusts to the retinol formula.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: Small quantity (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Prevents breakouts (sometimes noted)
- Disliked: Drying and irritation (sometimes noted)
- Disliked: Ineffective on wrinkles (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Neutrogena Stubborn Marks PM Treatment a great fit for skin with dark spots?

Neutrogena Stubborn Marks PM Treatment is a great fit because it contains retinol and ascorbic acid, which help brighten dark spots while smoothing and renewing your skin. Sodium hyaluronate further boosts hydration to improve overall skin texture, and the formula is designed to be safe and soothing for your skin.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Which ingredients make this treatment a good fit for skin with dark spots?

This treatment is a great fit for skin with dark spots because it contains retinol and ascorbic acid, which work to brighten your skin and smooth its texture. Sodium hyaluronate is also included to provide deep hydration and further enhance these results.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Retinol SA do for skin with dark spots?

Retinol helps fade dark spots and uneven skin tone by encouraging skin renewal. It may also smooth fine lines and improve overall texture over several weeks of regular use, though some dryness or stinging can happen.
Sources: [Journal of Drugs in Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27050703/), [Journal of Drugs in Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27391637/)

### What does Vitamin C do for skin with dark spots?

Vitamin C helps fade dark spots and brightens uneven skin. It works by slowing down pigment production and boosting overall skin clarity.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/), [Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029672/)

### Where does this treatment go in a skincare routine for skin with dark spots?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps things simple and safe around sun exposure. It helps fade dark spots and smooths texture by encouraging skin renewal while keeping skin calm.

### Can I use this treatment with benzoyl peroxide, and in what order?

You should use benzoyl peroxide and this retinol treatment on alternating nights rather than at the same time to help prevent excessive dryness and irritation. Applying them separately gives your skin time to adjust while still helping to fade dark spots and smooth your texture.

### How often should I use this treatment?

Use this treatment in your evening routine, starting once a week and slowly increasing the frequency as your skin feels comfortable. This helps renew your skin and brighten dark spots safely while keeping it smooth and calm.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Can this treatment clog pores, cause breakouts or purging for skin with dark spots?

This treatment is unlikely to clog pores or cause breakouts on skin with dark spots because it is free of heavy, pore-clogging ingredients. However, it contains retinol, which may cause temporary purging as it speeds up skin renewal to brighten dark spots.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Stearyl alcohol and cetearyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for skin with dark spots

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dark-spots) — High fit — €10.20 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/nl/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/dark-spots) — High fit — €99.41 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/nl/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — €203.88 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/nl/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €21.00 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/nl/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €14.31 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/dark-spots) — Superior fit — €19.20 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentaerythrityl Tetraethylhexanoate, Dimethicone, Glycerin, Ppg-15 Stearyl Ether, Stearyl Alcohol, Cetearyl Alcohol, Butylene Glycol, Ceteareth-20, Isohexadecane, Dimethicone Crosspolymer, Trisiloxane, Phenoxyethanol, Caprylyl Glycol, Ammonium Acryloyldimethyltaurate Vp Copolymer, Polyacrylamide, C13-14 Isoparaffin, Chlorphenesin, Hydrolyzed Myrtus Communis Leaf Extract, Polysorbate 20, Bht, Retinol, Disodium Edta, Sodium Hyaluronate, Ascorbic Acid, Laureth-7, Sodium Hydroxide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots
- France: https://lovi.care/skincare/fr/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots (this page)
- Spain: https://lovi.care/skincare/es/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/neutrogena/stubborn-marks-pm-treatment/for/dark-spots