# Neora Advanced SIG-1273 Concentrated Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Neora](https://lovi.care/skincare/nl/brands/neora)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate hydration for your normal skin, as glycerin and sodium hyaluronate provide humectant benefits that are generally suitable for your skin type. These ingredients offer general skincare benefits, but are mostly supportive for your specific concerns of redness and irritation.
- The formula is highly suitable for normal skin due to the presence of sodium hyaluronate and glycerin with humectant action.
- The safety profile is excellent, with no risks of irritation for your normal skin with sensitivity due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Glycerin, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentylene Glycol, Citric Acid

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Exposure of epidermal full-thickness skin equivalents to a blend of betaine, pentylene glycol, Saccharomyces cerevisiae, and Rhodiola rosea root extract significantly increased antioxidant, skin barrier, and oxidative stress biomarkers while reducing the negative impact of hydrogen peroxide on MMP3, MMP12, FBN2, ANXA1, and HGF, whereas a blend of Narcissus tazetta bulb extract and Schisandra chinensis fruit extract significantly increased 8 growth factors, 7 signaling, 7 structural/barrier function, 7 oxidative stress biomarkers, and specific microRNAs over control levels. ([International Journal of Molecular Sciences, 2018](https://pubmed.ncbi.nlm.nih.gov/30373163/))
- A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris. ([Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/))
- Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/))
- Topical 20% citric acid lotion increases viable epidermal thickness and dermal glycosaminoglycan content in sun-damaged skin compared to vehicle alone. ([Dermatologic Surgery, 1997](https://pubmed.ncbi.nlm.nih.gov/9256916/))

## Why other serums fit sensitive skin better

- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))

## What reviewers say

Based on limited data, users describe the serum as a lightweight, hydrating formula that leaves skin feeling smooth and looking radiant. While many report improvements in skin texture and a healthy glow, some users feel the anti-aging results are subtle rather than dramatic, especially when weighed against the product's premium price point.

- Disliked: High price (mostly mentioned)
- Liked: Hydrating effect (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Radiant glow (sometimes noted)
- Liked: Smoother skin (sometimes noted)
- Disliked: MLM model (sometimes noted)
- Disliked: Subtle results (sometimes noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Advanced SIG-1273 Concentrated Serum work for sensitive skin?

This serum works moderately well for sensitive skin, offering basic hydration that is generally safe but mostly supportive rather than targeting redness and irritation directly. A treatment for this skin needs potent antioxidants, skin-repairing ingredients like niacinamide or snail secretion filtrate, and calming components that actively soothe redness and irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for sensitive skin?

Sodium hyaluronate and glycerin make this serum a good fit for sensitive skin by offering gentle, moderate hydration. This product of this type needs effective ingredients that target redness and irritation, potent antioxidants, and skin-repairing components to provide a superior fit for sensitive skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### What does Glycerin do for sensitive skin?

Glycerin helps keep sensitive skin soft and deeply hydrated while supporting the skin barrier. It is unlikely to cause irritation and may protect against dryness and roughness.
Sources: [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/), [Acta Dermato-venereologica, 1999](https://pubmed.ncbi.nlm.nih.gov/10598752/)

### Where does this serum go in a skincare routine for sensitive skin?

This serum goes in the evening routine after cleansing and toning, and before moisturizing. While it provides moderate hydration, sensitive skin prone to redness and irritation needs additional soothing and calming ingredients to truly thrive.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first in your evening routine and following with a soothing moisturizer. This approach helps support comfort while keeping your skin calm and hydrated.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

You can use this treatment in your evening routine, as this helps keep things simple and safe around sun exposure. A product of this type needs soothing ingredients like Centella asiatica stem cells extract and extra hydration to properly calm redness and irritation on sensitive skin.

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin because it lacks heavy, pore-blocking ingredients and has a very safe formula. It helps keep skin comfortable without triggering irritation, though a product for this skin needs extra soothing and calming ingredients to truly target redness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

## Alternatives for sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €160.00 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €35.50 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/nl/p/cosrx/the-vitamin-c-23-serum/for/sensitive-skin) — High fit — €19.00 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/nl/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €21.95 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/nl/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €17.96 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/nl/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — €19.79 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Glycerin, Sodium Hyaluronate, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentasodum Pentetate, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin (this page)
- Spain: https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin