# Neora Advanced SIG-1273 Concentrated Serum for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Neora](https://lovi.care/skincare/nl/brands/neora)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Offers moderate hydration for your dry skin due to the presence of glycerin and sodium hyaluronate, which provide humectant effects to support moisturizing.
- Pentylene glycol offers additional hydration, though the formula lacks sufficient emollient ingredients for optimal results on dry skin.
- The product is safe for your dry skin as it contains no prohibited or harsh ingredients, minimizing the risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Glycerin, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentylene Glycol, Citric Acid

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Exposure of epidermal full-thickness skin equivalents to a blend of betaine, pentylene glycol, Saccharomyces cerevisiae, and Rhodiola rosea root extract significantly increased antioxidant, skin barrier, and oxidative stress biomarkers while reducing the negative impact of hydrogen peroxide on MMP3, MMP12, FBN2, ANXA1, and HGF, whereas a blend of Narcissus tazetta bulb extract and Schisandra chinensis fruit extract significantly increased 8 growth factors, 7 signaling, 7 structural/barrier function, 7 oxidative stress biomarkers, and specific microRNAs over control levels. ([International Journal of Molecular Sciences, 2018](https://pubmed.ncbi.nlm.nih.gov/30373163/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- A novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid showed similar tolerance and efficacy compared with clindamycin 1% and benzoyl peroxide 5% gel in subjects with acne vulgaris. ([Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23545907/))
- Daily treatment with a facial serum containing multiple acids reduced post-inflammatory hyperchromia lesion grade and number by 29.4% at 56 days, and decreased skin oiliness by 30.7% at 7 days in Brazilian patients with acne vulgaris. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33617668/))
- Topical 20% citric acid lotion increases viable epidermal thickness and dermal glycosaminoglycan content in sun-damaged skin compared to vehicle alone. ([Dermatologic Surgery, 1997](https://pubmed.ncbi.nlm.nih.gov/9256916/))

## Why other serums fit dry skin better

- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))

## What reviewers say

Based on limited data, users describe the serum as a lightweight, hydrating formula that leaves skin feeling smooth and looking radiant. While many report improvements in skin texture and a healthy glow, some users feel the anti-aging results are subtle rather than dramatic, especially when weighed against the product's premium price point.

- Disliked: High price (mostly mentioned)
- Liked: Hydrating effect (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Radiant glow (sometimes noted)
- Liked: Smoother skin (sometimes noted)
- Disliked: MLM model (sometimes noted)
- Disliked: Subtle results (sometimes noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does the Neora Advanced SIG-1273 Concentrated Serum work for dry skin?

Neora Advanced SIG-1273 Concentrated Serum works for dry skin by offering moderate hydration through glycerin, sodium hyaluronate, and pentylene glycol, though it lacks enough smoothing ingredients to be an ideal match. A treatment for dry skin needs rich hydrators, soothing ingredients, and skin barrier supporters like ceramides, niacinamide, and peptides.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry skin?

Glycerin, sodium hyaluronate, and pentylene glycol make this serum a fit for dry skin by providing moderate hydration through moisture-binding effects. However, this product needs additional softening ingredients like ceramides, niacinamide, or plant oils to properly care for dry skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Hyaluronic Acid do for dry skin?

Hyaluronic acid draws moisture into dry skin, giving an immediate and lasting boost in hydration that helps smooth out fine lines and soften rough patches. It is very gentle and unlikely to cause irritation while improving overall skin smoothness and plumpness.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### What does Glycerin do for dry skin?

Glycerin helps dry skin by drawing in moisture and keeping it locked in, which makes the skin feel much softer and smoother. It also supports your natural skin barrier to stop water from escaping easily. A product for dry skin needs extra ingredients like hyaluronic acid and soothing plant extracts to truly calm and hydrate dry patches.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The British Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18510666/)

### Where does this serum go in a skincare routine for dry skin?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps the routine simple and safe. Dry skin of this type needs rich moisturizing ingredients and softening oils to lock in hydration and smooth rough spots.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum before your retinol product at night, or by using the serum in the morning and retinol at night to keep your dry skin comfortable. This product provides moderate hydration through glycerin and sodium hyaluronate, but dry skin also needs rich softening ingredients like plant oils or butters to lock in moisture and prevent dryness.

### How often should I use this serum?

Use this serum in the evening. It provides moderate hydration for dry skin, but dry skin needs extra rich smoothing ingredients like petrolatum or plant oils to truly lock in moisture.

### Can this serum clog pores, cause breakouts or purging for dry skin?

This serum is unlikely to clog pores, cause breakouts, or lead to purging on dry skin because it contains no harsh or heavy ingredients that typically trigger irritation or congestion. It is safe to use, though dry skin generally needs richer ingredients like heavy oils or butters to lock in moisture and smooth rough patches.

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — €10.20 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/nl/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €25.00 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/nl/p/augustinus-bader/the-serum/for/dry-skin) — Superior fit — €474.90 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/nl/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — €21.95 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/nl/p/dear-klairs/supple-preparation-unscented-toner/for/dry-skin) — Superior fit — €16.89 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/nl/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/dry-skin) — Superior fit — €48.84 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Pentylene Glycol, Glycerin, Sodium Hyaluronate, Disodium Tetramethylhexadecenyl Succinoyl Cysteine, Pentasodum Pentetate, Citric Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin
- France: https://lovi.care/skincare/fr/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin (this page)
- Spain: https://lovi.care/skincare/es/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/neora/advanced-sig-1273-concentrated-serum/for/dry-skin