# NATURIUM Multi-Peptide Moisturizer for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/nl/p/naturium/multi-peptide-moisturizer/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [NATURIUM](https://lovi.care/skincare/nl/brands/naturium)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/nl/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your combination skin, the presence of niacinamide and sodium hyaluronate supports barrier repair and hydration, while glycerin and squalane offer excellent moisturizing benefits to enhance barrier resilience.
- The formula provides general skincare benefits like hydration and soothing, which can be supportive for managing oily shine on combination skin.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/naturium/multi-peptide-moisturizer/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/naturium/multi-peptide-moisturizer/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/naturium/multi-peptide-moisturizer/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/nl/p/naturium/multi-peptide-moisturizer/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/naturium/multi-peptide-moisturizer/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/naturium/multi-peptide-moisturizer/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/naturium/multi-peptide-moisturizer/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/naturium/multi-peptide-moisturizer/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/naturium/multi-peptide-moisturizer/for/oily-acne-prone-skin): High

## Key ingredients

Multi-Peptide Blend, 3-O-Ethyl Ascorbic Acid Ethylated Vitamin C, Panthenol Vitamin B5, Squalane, Niacinamide

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- A topical serum with a peptide blend showed superior or comparable skin recovery to a moisturizer following fractional CO2 laser and radiofrequency microneedling in Asian subjects. ([Dermatology and Therapy, 2026](https://pubmed.ncbi.nlm.nih.gov/42322532/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))

## What reviewers say

This moisturizer is highly praised for its lightweight and absorbent texture, making it suitable for oily and combination skin types. It effectively plumps fine lines and improves skin texture, providing a smooth base for makeup. However, users with very dry skin may find it insufficient for their hydration needs and might require additional layering. A small number of reviews mention issues with the pump packaging or experiencing breakouts.

- Liked: Lightweight & Absorbent (mostly mentioned)
- Liked: Makeup Compatibility (often mentioned)
- Liked: Sanitary Packaging (sometimes noted)
- Liked: Skin Texture & Plumping (sometimes noted)
- Liked: Value for Money (sometimes noted)
- Disliked: Not hydrating enough (sometimes noted)
- Disliked: Breakouts/Irritation (rarely noted)
- Disliked: Packaging malfunctions (rarely noted)
- Disliked: Pilling issues (rarely noted)
- Disliked: Small quantity (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Naturium Multi-Peptide Moisturizer a great fit for combination skin?

This moisturizer is a great fit because ingredients like niacinamide and sodium hyaluronate help keep skin hydrated and repair the skin barrier. Glycerin and squalane provide great moisturizing benefits that make the skin soft, while the formula helps manage oily shine and has an excellent safety profile without harsh ingredients.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for combination skin?

This cream is a great fit for combination skin because it contains niacinamide and sodium hyaluronate to support moisture and barrier repair, alongside glycerin and squalane to keep the skin soft. These ingredients provide balanced hydration while helping to manage oily shine safely without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What do Peptides do for combination skin?

Peptides help combination skin by supporting firmness, smoothing out wrinkles, and improving hydration without feeling heavy. They work by encouraging collagen production, which may help keep the skin looking smooth and bouncy.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40565185/), [International Journal of Molecular Medicine, 2017](https://pubmed.ncbi.nlm.nih.gov/27878236/)

### What does 3-O-Ethyl Ascorbic Acid do for combination skin?

3-O-Ethyl Ascorbic Acid helps brighten combination skin and may reduce dark spots and uneven tone. Laser pretreatment can further boost how well this vitamin C derivative sinks into the skin.
Sources: [Lasers in Medical Science, 2011](https://pubmed.ncbi.nlm.nih.gov/21120566/)

### Where does this cream go in a skincare routine for combination skin?

This cream goes as the third step in your morning routine after your cleanser and hydrating toner, and as the last step in your evening routine after your cleanser, toner, and treatment. It is a great fit for your skin because ingredients like niacinamide, sodium hyaluronate, glycerin, and squalane support hydration and barrier repair while helping manage oily shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the moisturizer either before or after your retinol treatment to help keep your skin comfortable and hydrated. Using a barrier-enhancing moisturizer alongside retinoids is unlikely to cause irritation and may support your skin during treatment.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this cream twice daily as part of your morning and evening routine to keep your skin hydrated and supported. Regular application helps maintain moisture and is unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to cause breakouts or irritation for combination skin, as it has a very safe profile and lacks harsh ingredients. It also helps manage oily shine while keeping your skin hydrated.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around your eyes and on your body, as its gentle ingredients are suitable for thinner skin areas. The formula provides good hydration and has an excellent safety profile, making it unlikely to cause irritation.

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol and stearyl alcohol are fatty alcohols, which soften the skin.

## Alternatives for combination skin

- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/nl/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — €13.02 at Amazon
- [Anua Heartleaf 78% Soothing Cream](https://lovi.care/skincare/nl/p/anua/heartleaf-78-soothing-cream/for/combination-skin) — High fit — €25.29 at Amazon
- [ANUA Heartleaf 70% Soothing Cream](https://lovi.care/skincare/nl/p/anua/heartleaf-70-soothing-cream/for/combination-skin) — High fit — €25.29 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/nl/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €16.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/nl/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/nl/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/combination-skin) — Superior fit — €33.70 at Amazon

## Where to buy

- Amazon.nl: €49.99 (https://www.amazon.nl/dp/B09BG477N1?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Dimethicone, Jojoba Seed Oil, Squalane, Glyceryl Stearate, Cetyl Alcohol, Niacinamide, Stearyl Alcohol, Palmitoyl Tripeptide-5, Pantolactone, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Hydrolyzed Plukenetia Volubilis Seed Extract, Dunaliella Salina Extract, Sodium Hyaluronate, 3-O-Ethyl Ascorbic Acid, Panthenol, Caryodendron Orinocense Seed Oil, Honokiol, Magnolol, Palmitic Acid, Sorbitan Oleate, Aluminum Octenylsuccinate Starch, Hydroxyacetophenone, Stearic Acid, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, Polyglyceryl-6 Laurate, 1,2-Hexanediol, Boron Nitride, Caprylyl Glycol, Polyglyceryl-10 Oleate, Isohexadecane, Butylene Glycol, Chlorphenesin, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tocopheryl Acetate, Polysorbate 80, Sorbitan Palmitate, Sodium Hydroxide, Sodium Benzoate, Carbomer, Sodium Lactate, Phenoxyethanol, Polysorbate 20, Citric Acid, Ethylhexylglycerin, Potassium Sorbate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/naturium/multi-peptide-moisturizer/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/naturium/multi-peptide-moisturizer/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/naturium/multi-peptide-moisturizer/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/naturium/multi-peptide-moisturizer/for/combination-skin
- France: https://lovi.care/skincare/fr/p/naturium/multi-peptide-moisturizer/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/naturium/multi-peptide-moisturizer/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/naturium/multi-peptide-moisturizer/for/combination-skin (this page)
- Spain: https://lovi.care/skincare/es/p/naturium/multi-peptide-moisturizer/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/naturium/multi-peptide-moisturizer/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/naturium/multi-peptide-moisturizer/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/naturium/multi-peptide-moisturizer/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/naturium/multi-peptide-moisturizer/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/naturium/multi-peptide-moisturizer/for/combination-skin