NATURIUM Multi-Peptide Advanced Serum for oily acne-prone skin
Multi-Peptide Blend
Ferulic Acid
Hydrolyzed Collagen
Squalane
Acetyl Hexapeptide-8
Average
- AverageOily Skin Fit
- AverageEffectiveness
- HighSafety
Works for oily acne-prone skin; other serums fit it better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- American Journal of Clinical Dermatology, 2013
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for your oily skin, as Ferulic Acid and Glycerin provide antioxidant and humectant benefits, but it lacks sufficient ingredients for optimal oil control to address your primary concerns of acne, blemishes, and breakouts.
- While peptides like Acetyl Hexapeptide-8 and Copper Palmitoyl Heptapeptide-14 are present to minimize fine lines and wrinkles, their concentration is not ideal for your main goals.
- The product is safe for your oily skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing agents like sunflower extract and rosemary leaf extract.
How to apply
- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
People Say
★4.4Overall rating based on 400+ reviewsUsers with dry, mature, and sensitive skin frequently praise this serum for its ability to visibly plump fine lines and deliver a "glass-skin" radiance without irritation. Many report smoother texture and improved hydration, while a minority of users experienced breakouts or frustration with the packaging design.
Highlights
Elegant texture Often Mentioned
- “silky application”
- “absorbs quickly”
- “layers well”
- “non-sticky finish”
Hydrating and plumping Often Mentioned
- “deeply moisturizing”
- “skin feels bouncy”
- “lightweight hydration”
- “non-greasy feel”
Improves skin texture Often Mentioned
- “smoother complexion”
- “softer skin”
- “reduces roughness”
- “glass-like finish”
Great value Sometimes Noted
- “affordable price”
- “high-quality ingredients”
- “beats expensive brands”
- “good size”
Visible anti-aging Sometimes Noted
- “fine lines softened”
- “firmer appearance”
- “youthful glow”
- “less tired-looking”
Poor pump design Sometimes Noted
- “pump stops working”
- “hard to dispense”
- “product left at bottom”
- “cap breaks easily”
Caused breakouts Rarely Noted
- “cystic acne”
- “small bumps”
- “clogged pores”
- “skin reaction”
Runs out quickly Rarely Noted
- “bottle empties fast”
- “small quantity”
- “opaque bottle hides level”
- “used up in weeks”
Skin irritation Rarely Noted
- “stinging sensation”
- “burning upon application”
- “redness”
- “sensitivity flare-up”
Sources: lovi.care, naturium.com, space nk.com, target.com, ulta.com, reddit.com, and more
Questions and answers
How well does the Multi-Peptide Advanced Serum work for oily acne-prone skin?
This serum offers moderate suitability for oily skin, but it lacks sufficient ingredients for oil control to effectively address blemishes and breakouts. Treatments that fit this skin better need ingredients like niacinamide and propolis to target excess oil and acne while keeping the skin comfortable.
Which ingredients make this serum a good fit for oily acne-prone skin?
Ferulic acid and glycerin help provide antioxidant and moisture benefits for oily skin. A product for this skin needs effective ingredients like niacinamide and propolis that manage excess oil and target blemishes.
What do Peptides do for oily acne-prone skin?
Peptides help oily, acne-prone skin by fighting the bacteria that cause breakouts and calming swelling. These ingredients target acne-causing germs while keeping your skin calm, smooth, and healthy without clogging pores.
What does Ferulic Acid do for oily acne-prone skin?
Ferulic acid helps protect oily, acne-prone skin from sun damage and supports recovery after breakouts or treatments. This ingredient reduces redness and dark marks while helping to calm irritation.
Journal of the American Academy of Dermatology, 2008Journal of Cosmetic Dermatology, 2008
Where does this serum go in a skincare routine for oily acne-prone skin?
This treatment serum goes in the evening routine after cleansing and before moisturizing, keeping it simple and safe around sun exposure. It is safe for oily skin and unlikely to cause irritation because it lacks harsh ingredients and contains soothing plant extracts. However, because it offers only moderate suitability for this skin type, an oily acne-prone product needs powerful oil-controlling ingredients like salicylic acid or niacinamide to properly address blemishes and breakouts.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol, applying the treatment after your cleanser and before your moisturizer. It is unlikely to cause irritation on oily skin, but an ideal product for this skin type needs targeted ingredients for oil control to better manage breakouts.
How often should I use this serum?
You can use this treatment serum in the evening. This product works for your oily acne-prone skin, though an oily acne-prone skin needs a product with strong oil-controlling and breakout-clearing ingredients.
Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?
This serum is unlikely to cause breakouts on oily skin, as it has a safe formula with soothing plant extracts and no harsh ingredients, though a few reviewers have reported occasional blemishes. For better results with acne and breakouts, oily acne-prone skin needs a product with targeted oil-controlling ingredients to manage excess oil effectively.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.
American Journal of Clinical Dermatology, 2013Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.
Journal of Cosmetic and Laser Therapy, 2013Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.
Journal of Cosmetic Dermatology, 2017A topical serum with a peptide blend showed superior or comparable skin recovery to a moisturizer following fractional CO2 laser and radiofrequency microneedling in Asian subjects.
Dermatology and Therapy, 2026Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening.
Dermatologic Therapy, 2022Combining fractional microneedle radiofrequency with a topical antioxidant serum significantly reduced wrinkle severity by 29.9% versus 18.0%, increased elasticity by 12.9% versus 2.3%, and improved aesthetic outcomes in 31 participants compared to radiofrequency and placebo.
The Journal of Dermatological Treatment, 2025Pretreatment with a topical antioxidant mixture of vitamin C, ferulic acid, and phloretin attenuated ultraviolet-induced sunburn cell formation, thymine dimer formation, matrix metalloproteinase-9 expression, p53 protein expression, and the suppression of CD1a-expressing Langerhans cells in human skin compared to vehicle control.
Journal of Cosmetic Dermatology, 2008Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.
Journal of Cosmetic Dermatology, 2022Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.
International Journal of Molecular Sciences, 2022Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.
Marine Drugs, 2023Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.
Annals of Dermatology, 2019Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.
European Journal of Neurology, 2013Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.
International Journal of Biological Macromolecules, 2026
Why other serums fit oily acne-prone skin better
A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo.
Clinical Pharmacology, 2018
Ingredients
Water, Propanediol, Caprylic Capric Triglyceride, Isopentyldiol, Ethylhexyl Polyhydroxystearate, Squalane, Tetradecane, Glyceryl Stearate Citrate, Butyrospermum Parkii Butter Shea Butter, Polyglyceryl-3 Stearate, Helianthus Annuus Extract Sunflower Extract, Rice Bran Extract, Mannitol, Phosphatidylcholine, Ferulic Acid, Arginine, Acetyl Hexapeptide-8, Copper Palmitoyl Heptapeptide-14, Palmitoyl Sh-Hexapeptide-13 Serine Sp Amide, Hydrolyzed Collagen, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Lactic Acid Glycolic Acid Copolymer, Glycerin, Tocopherol, Pullulan, Lysolecithin, Sclerotium Gum, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Dimethicone, Sodium Phytate, Diglycerin, Hydrogenated Lecithin, Silica, Cetyl Alcohol, Hydroxyacetophenone, Polysorbate 60, Sorbitan Isostearate, Sodium Hydroxide, Sodium Benzoate, Potassium Sorbate, Polyvinyl Alcohol, Decyl Glucoside, Xanthan Gum, Tocopheryl Acetate, Sodium Chloride, Citric Acid, Phenoxyethanol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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