# Natura Bissé C+C Vitamin Complex for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Natura Bissé](https://lovi.care/skincare/nl/brands/natura-bisse)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate brightening and evening of skin tone for your normal skin due to Sodium Ascorbyl Phosphate, which provides antioxidant activity and supports barrier repair. Glycerin and Rosa Canina Oil Fruit offer general hydration, but lack specialized ingredients to effectively target your wrinkles and fine lines.
- The formula is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.
- The presence of Tocopheryl Acetate further supports barrier repair, contributing to overall skin health.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/acne-prone-skin): Low
- [Skin with dark spots](https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/oily-acne-prone-skin): Low

## Key ingredients

Ascorbic Acid, Vitamin E, Rosa Canina Oil Fruit, Hydrolyzed Collagen, Tocopherol

## What the research says

- The tetrapeptide PKEK exerts skin whitening effects by reducing UVB-stimulated mRNA expression of pigmentation-inducing mediators like POMC and tyrosinase, and significantly fades facial pigment spots when combined with sodium ascorbyl phosphate. ([Experimental Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22142309/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Co-encapsulation of alpha-tocopherol and alpha-tocopheryl acetate in nanostructured lipid carrier gel formulations significantly enhanced moisture retention up to 68% and improved skin elasticity in human volunteers compared to a solution gel. ([Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))
- A topical antioxidant serum significantly reduced air pollution-induced skin pigmentation and proinflammatory gene expression ex vivo, and improved skin aging signs in 40 healthy adult females after 90 days of daily use. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/))
- Topical treatments containing rosehip extract may reduce the size and erythema of postsurgical scars through macrophage polarization and inflammatory cytokine inhibition, though current clinical evidence remains insufficient to recommend its routine use. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37605366/))
- Sunflower and rosehip oil nanoemulsions prepared with a mix of phospholipids and synthetic emulsifiers permeated intact skin to the dermis and showed a more prominent healing effect in a human organotypic skin explant culture wound model compared to nanoemulsions prepared only with phospholipids. ([Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/36986857/))
- A nanoemulsion containing 1 mg/mL kojic dipalmitate and 5% rosehip oil demonstrated high incorporation efficiency, suitable physicochemical stability, antioxidant and depigmenting efficacy close to 1 mM ascorbic acid, and no cytotoxicity at concentrations from 0.06% to 1% in vitro. ([Pharmaceutics, 2023](https://pubmed.ncbi.nlm.nih.gov/36839792/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))

## What reviewers say

Based on limited data, users consistently praise this serum for its potent brightening abilities, noting that it effectively revitalizes dull, tired-looking skin and improves overall radiance. The lightweight, fast-absorbing texture is a hit, though some users with sensitive skin caution against potential irritation due to the high concentration of Vitamin C and strong citrus fragrance.

- Liked: Brightens dull skin (often mentioned)
- Disliked: High price (often mentioned)
- Liked: Lightweight texture (sometimes noted)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Potential irritation (sometimes noted)
- Liked: Firming effect (rarely noted)
- Disliked: Availability issues (rarely noted)
- Disliked: Strong fragrance (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Natura Bissé C+C Vitamin Complex work for mature skin?

Natura Bissé C+C Vitamin Complex works moderately well for mature skin, providing basic hydration and brightening while safely avoiding irritation. However, it lacks specialized ingredients to effectively target wrinkles and fine lines. A product of this type needs high-quality anti-aging ingredients, potent antioxidants, peptides, and humectants that improve skin elasticity and smooth out lines for mature skin.
Sources: [Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/)

### Which ingredients make this serum a good fit for mature skin?

Ascorbic Acid and Tocopherol help brighten skin and support overall skin health, while Rosa Canina Oil Fruit and Glycerin provide general hydration. However, to truly fit mature skin, a product of this type needs specialized ingredients that effectively target wrinkles and fine lines and improve skin elasticity.
Sources: [Scientific Reports, 2025](https://pubmed.ncbi.nlm.nih.gov/41309687/)

### What does Vitamin C do for mature skin?

Vitamin C helps mature skin by smoothing out wrinkles, brightening dark spots, and boosting firmness. It works by encouraging collagen production to keep skin looking youthful and radiant.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Vitamin E do for mature skin?

Vitamin E helps mature skin by improving moisture, smoothing fine lines, and keeping it feeling soft and firm. It works as an antioxidant to protect against daily stress and may help support collagen to keep skin looking youthful.
Sources: [Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35150043/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32129554/)

### Where does this serum go in a skincare routine for mature skin?

Apply this treatment in the evening after cleansing and toning, followed by your moisturizer. Mature skin needs specialized ingredients like firming peptides, retinoids, or targeted antioxidants to effectively reduce wrinkles and fine lines.

### Can I use this serum with retinol, and in what order?

You can use this treatment with retinol by applying the retinol first and following it with this serum, or by using retinol at night and this serum in the morning. This formula is safe for your skin with no risks of irritation. To better care for mature skin, a product of this type needs specialized ingredients that target wrinkles and fine lines.

### How often should I use this serum?

This treatment is used in the evening in your routine for simplicity and extra safety around sun exposure. Mature skin needs a product with collagen-boosting ingredients and targeted anti-aging actives to effectively smooth fine lines and wrinkles.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as its ingredients have a safe profile with no harsh irritants. However, to truly care for mature skin, a product of this type needs specialized ingredients like firming peptides or retinoids to effectively target wrinkles and fine lines.
Sources: [Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum, limonene, and linalool).

## Alternatives for mature skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €160.00 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vita-c-serum/for/mature-skin) — High fit — €35.50 at Amazon
- [La Mer The Regenerating Serum](https://lovi.care/skincare/nl/p/la-mer/the-regenerating-serum/for/mature-skin) — High fit — €419.00 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/nl/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €48.84 at Amazon

## Where to buy

- Amazon.nl: €131.00 (https://www.amazon.nl/dp/B0B7B9KDCZ?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Notino: €94.90 (https://www.notino.nl/natura-bisse/cc-vitamin-oil-free-gel-hydraterende-gel-creme-met-verstevigende-werking/p-16271341/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Sodium Ascorbyl Phosphate, Sodium Acrylates Copolymer, Propanediol, Glycerin, Hydrogenated Polyisobutene, Rosa Canina Oil Fruit, Hydrolyzed Opuntia Ficus-Indica Flower Extract, Citric Acid, Tocopheryl Acetate, Anogeissus Leiocarpus Bark Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Hydrolyzed Collagen, Sodium Chondroitin Sulfate, Prunus Amygdalus Dulcis Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Polysorbate 60, Sorbitan Stearate, Disodium Edta, Tocopherol, Potassium Sorbate, Phenoxyethanol, Parfum, Limonene, Linalool, Citrus Nobilis Oil Mandarin Orange Oil, Citrus Aurantium Dulcis Oil, Amyl Cinnamal, Yellow 5 Ci 19140
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/natura-bisse/c-c-vitamin-complex/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/natura-bisse/c-c-vitamin-complex/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/natura-bisse/c-c-vitamin-complex/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/natura-bisse/c-c-vitamin-complex/for/mature-skin
- France: https://lovi.care/skincare/fr/p/natura-bisse/c-c-vitamin-complex/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/natura-bisse/c-c-vitamin-complex/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/natura-bisse/c-c-vitamin-complex/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/natura-bisse/c-c-vitamin-complex/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/natura-bisse/c-c-vitamin-complex/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/natura-bisse/c-c-vitamin-complex/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/natura-bisse/c-c-vitamin-complex/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/natura-bisse/c-c-vitamin-complex/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/natura-bisse/c-c-vitamin-complex/for/mature-skin