# Missha Time Revolution The First Treatment Essence RX for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/nl/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Missha](https://lovi.care/skincare/nl/brands/missha)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few serums fit it even better.

## Why this fit

- Offers excellent skin treatment for your combination skin, as Saccharomyces Ferment Filtrate and Bifida Lysate Ferment enhance barrier resilience and provide humectant action. Niacinamide and lactic acid further support skin renewal and pore refinement, addressing your concerns with acne, blemishes, and breakouts.
- The formula is highly suitable for your combination skin, with Saccharomyces Ferment Filtrate and Bifida Lysate Ferment offering good barrier repair and humectant action.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/missha/time-revolution-the-first-treatment-essence-rx/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/missha/time-revolution-the-first-treatment-essence-rx/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/missha/time-revolution-the-first-treatment-essence-rx/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/missha/time-revolution-the-first-treatment-essence-rx/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/nl/p/missha/time-revolution-the-first-treatment-essence-rx/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/missha/time-revolution-the-first-treatment-essence-rx/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/missha/time-revolution-the-first-treatment-essence-rx/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/missha/time-revolution-the-first-treatment-essence-rx/for/oily-acne-prone-skin): High

## Key ingredients

Saccharomyces Ferment Filtrate, Bifida Lysate Ferment, Niacinamide, Hordeum Vulgare Extract, Pro Ferment

## What the research says

- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Application of Galactomyces ferment filtrate skin care formula significantly reduced the net values and daily fluctuation of facial pore area, roughness, and redness in young Japanese women. ([Journal of Clinical Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34198790/))
- Topical moisturizers improved skin barrier function and surface moisture, while a postbiotic moisturizer with yeast extract uniquely supported microbiome balance and modulated biomarkers of skin barrier, structure, and inflammation in participants and ex vivo explants exposed to environmental aggressors. ([Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/37763018/))
- A maintenance therapy with a cosmeceutical formulation containing hydroxyphenoxy propionic acid, ellagic acid, yeast extract, and salicylic acid over 20 weeks significantly improved even skin tone, spot intensity, spot size, and overall hyperpigmentation in 33 healthy subjects with moderate facial dyspigmentation. ([Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25844613/))
- A methanol yeast extract increases proliferation and migration while decreasing entrance into senescence and apoptosis phases in 3T3 fibroblast cells. ([Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/25898765/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))

## What reviewers say

Based on a very large amount of data, users consistently praise this essence for its ability to deeply hydrate and brighten dull skin, often citing it as a cost-effective alternative to luxury products. While it effectively smooths texture and strengthens the moisture barrier for most, a minority of users with fungal acne-prone skin report breakouts due to the fermented ingredients.

- Liked: Brightening Glow (often mentioned)
- Liked: Deep Hydration (often mentioned)
- Liked: Fast Absorption (often mentioned)
- Liked: Texture Refinement (sometimes noted)
- Liked: Value for Money (sometimes noted)
- Disliked: Lack of Results (sometimes noted)
- Disliked: Acne Breakouts (rarely noted)
- Disliked: Sticky Residue (rarely noted)
- Disliked: Unpleasant Scent (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Missha Time Revolution Essence RX a great fit for acne-prone skin?

Missha Time Revolution The First Treatment Essence RX is a great fit because Saccharomyces Ferment Filtrate and Bifida Lysate Ferment strengthen your skin barrier while niacinamide and lactic acid help clear breakouts and refine pores. This formula has an excellent safety profile with soothing ingredients that are unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which ingredients make this treatment a good fit for acne-prone skin?

Saccharomyces Ferment Filtrate and Bifida Lysate Ferment make this treatment a great fit by strengthening your skin barrier and keeping it hydrated. Niacinamide and lactic acid further help by clearing pores and managing breakouts.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### What does Saccharomyces Ferment Filtrate do for acne-prone skin?

Saccharomyces ferment filtrate helps balance oily skin and keeps pores clear, while also calming redness. A product of this type needs soothing ingredients like Centella asiatica and barrier-strengthening fermented components to properly care for acne-prone skin.

### What does Bifida Ferment Lysate do for acne-prone skin?

Bifida Ferment Lysate helps acne-prone skin by calming redness and keeping the skin barrier strong. This ingredient may also support the skin's defenses against irritation, making it less likely to flare up.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/)

### Where does this treatment go in a skincare routine for acne-prone skin?

This treatment goes in your evening routine, applied after cleansing and before your moisturizer. It is very unlikely to cause irritation thanks to soothing components and the absence of harsh ingredients.

### Can I use this treatment with retinol, and in what order?

Yes, you can use this treatment with retinol by applying the treatment first and following with your retinol once it is absorbed. Niacinamide and fermented ingredients help support skin renewal and strengthen the skin barrier, which may reduce the irritation sometimes caused by retinoids.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### How often should I use this treatment?

You can use this treatment in your evening routine, applying it after cleansing and toning. The formula has an excellent safety profile with soothing components and no harsh ingredients, making it very gentle for regular use.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Can this treatment clog pores, cause breakouts or purging for acne-prone skin?

This treatment is unlikely to clog pores or cause breakouts for acne-prone skin, as it has an excellent safety profile with soothing components and no harsh ingredients. Ingredients like Saccharomyces Ferment Filtrate and Bifida Lysate Ferment help strengthen the skin barrier while niacinamide and lactic acid support skin renewal and pore refinement.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — €10.20 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €35.80 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/nl/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/acne-prone-skin) — Superior fit — €99.41 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/nl/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.99 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €19.20 at Amazon

## Where to buy

- Amazon.nl: €36.06 (https://www.amazon.nl/dp/B07MPB27B1?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Notino: €43.50 (https://www.notino.nl/missha/time-revolution-the-first-treatment-essence-5x-extreme-ferment-geconcentreerde-hydraterende-essentie-voor-regeneratie-en-huid-herstel/p-16105472/)
Prices checked 17 Oct – 5 Nov 2026.

## Ingredients

Saccharomyces Ferment Filtrate, Bifida Lysate Ferment, Water, Diethoxyethyl Succinate, Niacinamide, Hordeum Vulgare Extract, Cassia Alata Leaf Extract, Glycerin, Dipropylene Glycol, Dimethicone, Polyquaternium-51, 1,2-Hexanediol, Adenosine, Lecithin, Lactic Acid, Acetic Acid, Phenoxyethanol, Potassium Sorbate
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin (this page)
- Spain: https://lovi.care/skincare/es/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/missha/time-revolution-the-first-treatment-essence-rx/for/acne-prone-skin