# MEDIHEAL AGE-R for combination skin

**Lovi Fit: Low fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/mediheal/age-r/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [MEDIHEAL](https://lovi.care/skincare/nl/brands/mediheal)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for combination skin; the serums alongside fit it better.

## Why this fit

- Offers moderate skin firming for your combination skin due to collagen and peptides, which support elasticity and hydration without exacerbating oiliness.
- While the formula is safe and free of harsh ingredients for your combination skin, it lacks specialized ingredients to effectively target oily shine.
- The product is safe for your combination skin as it contains no prohibited or harsh ingredients, minimizing irritation risks.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/mediheal/age-r/for/oily-skin): Caution
- [Dry skin](https://lovi.care/skincare/nl/p/mediheal/age-r/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/nl/p/mediheal/age-r/for/combination-skin): Low (this page)
- [Sensitive skin](https://lovi.care/skincare/nl/p/mediheal/age-r/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/mediheal/age-r/for/acne-prone-skin): Low
- [Skin with dark spots](https://lovi.care/skincare/nl/p/mediheal/age-r/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/nl/p/mediheal/age-r/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/mediheal/age-r/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/mediheal/age-r/for/oily-acne-prone-skin): Caution

## Key ingredients

Glutathione, Collagen, Peptides

## What the research says

- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## What reviewers say

Based on a very large amount of data, users frequently achieve a 'glass skin' appearance and improved facial contouring, with many reporting enhanced product absorption and a more radiant complexion. While effective for dullness and mild sagging, results are highly dependent on consistent daily use, which some users find difficult to maintain. The device is also noted for improving skin texture and reducing pore visibility.

- Liked: Enhanced absorption (mostly mentioned)
- Liked: Glass skin glow (often mentioned)
- Disliked: Time-consuming routine (often mentioned)
- Liked: Improved texture (sometimes noted)
- Liked: Visible lifting (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Unpleasant sensation (sometimes noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### Why is Mediheal AGE-R a weak match for combination skin?

Mediheal AGE-R is a weak match for your combination skin because it lacks specialized ingredients to effectively target oily shine. A treatment of this type needs ingredients like niacinamide, propolis, or zinc PCA to balance oiliness and maintain skin health.
Sources: [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/), [Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/)

### Which ingredients make this treatment a poor fit for combination skin?

This treatment is a weak match for your combination skin because it lacks specialized ingredients like niacinamide, zinc PCA, or propolis to effectively target and regulate oily shine. To truly fit combination skin, a product of this type needs ingredients that balance moisture and manage oiliness without causing excess shine or dryness.
Sources: [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/), [Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/)

### What does Glutathione do for combination skin?

Glutathione helps brighten sun-exposed areas and reduce dark spots for combination skin, while also improving moisture and smoothness. It is unlikely to cause irritation and maintains a safe profile for regular use.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [International Journal of Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39444151/)

### What does Collagen do for combination skin?

Collagen helps keep combination skin smooth and hydrated by improving moisture and supporting elasticity. It is unlikely to cause irritation and may help reduce the appearance of fine lines while keeping the skin barrier balanced.
Sources: [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/), [Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/)

### Where does this treatment go in a skincare routine for combination skin?

This treatment goes in your evening routine, specifically after cleansing and before your moisturizer. A product of this type needs specialized ingredients like niacinamide to help manage oily shine while supporting your combination skin.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol, applying the treatment first and following with your retinol product. Because this product lacks oil-controlling ingredients, combination skin also needs lightweight balancing ingredients and oil-absorbing minerals to manage shine.

### How often should I use this treatment?

You can use this treatment in your evening routine, applying it after your cleansing toner and before your moisturizer. It is a weak match for combination skin, so this type of product needs added oil-absorbing ingredients to help manage oily shine while keeping the skin soft and smooth.
Sources: [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/), [Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/)

### Can it clog pores, cause breakouts or purging for combination skin?

Mediheal AGE-R is unlikely to clog pores or cause breakouts for your combination skin because it contains no harsh or heavy ingredients that typically trigger blemishes. However, since this weak match lacks specialized ingredients to control oily shine, combination skin that is prone to breakouts still needs oil-balancing ingredients like niacinamide or salicylic acid to stay clear.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — €10.20 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €35.80 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/nl/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €474.90 at Amazon

## Routine for combination skin

### AM

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/nl/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €16.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/nl/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/combination-skin) — Superior fit — €19.20 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/nl/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/combination-skin) — Superior fit — €33.70 at Amazon

### PM

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/nl/p/missha/ultra-hyalon-cleansing-cream/for/combination-skin) — Superior fit — €11.83 at Amazon
- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/nl/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €16.50 at Amazon
- Cleansing Toner: [Medicube Zero Pore Pad 2.0](https://lovi.care/skincare/nl/p/medicube/zero-pore-pad-2-0/for/combination-skin) — Superior fit — €16.99 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/nl/p/peach-and-lily/glass-skin-refining-serum/for/combination-skin) — Superior fit — €86.59 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/combination-skin) — Superior fit — €19.20 at Amazon

### Weekly

- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/nl/p/missha/ultra-hyalon-cleansing-cream/for/combination-skin) — Superior fit — €11.83 at Amazon
- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/nl/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €16.50 at Amazon
- Cleansing Toner: [Medicube Zero Pore Pad 2.0](https://lovi.care/skincare/nl/p/medicube/zero-pore-pad-2-0/for/combination-skin) — Superior fit — €16.99 at Amazon
- Cleansing Mask: [VT Cosmetics Cica Purifying Mask](https://lovi.care/skincare/nl/p/vt-cosmetics/cica-purifying-mask/for/combination-skin) — High fit — €15.72 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/nl/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Serum or Treatment: [Peach & Lily Glass Skin Refining Serum](https://lovi.care/skincare/nl/p/peach-and-lily/glass-skin-refining-serum/for/combination-skin) — Superior fit — €86.59 at Amazon

## Where to buy

- Amazon.nl: €369.95 (https://www.amazon.nl/dp/B0DQVVYXSJ?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Glutathione, Collagen, Peptides
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/mediheal/age-r/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/mediheal/age-r/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/mediheal/age-r/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/mediheal/age-r/for/combination-skin
- France: https://lovi.care/skincare/fr/p/mediheal/age-r/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/mediheal/age-r/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/mediheal/age-r/for/combination-skin (this page)
- Spain: https://lovi.care/skincare/es/p/mediheal/age-r/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/mediheal/age-r/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/mediheal/age-r/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/mediheal/age-r/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/mediheal/age-r/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/mediheal/age-r/for/combination-skin