# Medicube Zero Pore One-Day Cream for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-cream/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Medicube](https://lovi.care/skincare/nl/brands/medicube)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/nl/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your combination skin, this product effectively minimizes pores and smooths texture with salicylic acid and niacinamide, which also help regulate oil production in your oily shine areas.
- Glycerin and hyaluronic acid provide essential hydration and soothing benefits, supporting your overall skin health.
- The formula is safe for your combination skin, with no risks of irritation due to the absence of harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-cream/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-cream/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-cream/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-cream/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-cream/for/oily-acne-prone-skin): High

## Key ingredients

Panthenol, Bha, Glycerin, Niacinamide, Sodium Hyaluronate

## What the research says

- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical 5% benzoyl peroxide plus salicylic acid achieved the greatest lesion reduction at early 2 to 4 week time points compared to benzoyl peroxide, clindamycin, and combination benzoyl peroxide/clindamycin, while 5% benzoyl peroxide plus salicylic acid and combination benzoyl peroxide/clindamycin showed similar efficacy at 10 to 12 weeks in acne patients. ([Journal of the American Academy of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20488582/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Users with oily and combination skin appreciate this cream's lightweight, non-sticky texture that effectively balances moisture and controls sebum. Many report smoother skin texture and a reduction in the appearance of pores over time, though some find the "one-day" pore-shrinking claims to be exaggerated, suggesting it functions better as a daily moisturizer than a rapid treatment.

- Liked: Lightweight texture (often mentioned)
- Disliked: Strong fragrance (often mentioned)
- Liked: Oil control (sometimes noted)
- Liked: Skin smoothing (sometimes noted)
- Disliked: Slow results (sometimes noted)
- Disliked: Unsanitary packaging (sometimes noted)
- Liked: Pore maintenance (rarely noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes medicube Zero Pore One-Day Cream a great fit for combination skin?

This cream is a great fit because salicylic acid and niacinamide smooth your skin texture and help control oil in your shiny areas, while glycerin and hyaluronic acid provide essential hydration. The formula is safe for your skin type and is unlikely to cause irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/)

### Which ingredients make this cream a good fit for combination skin?

Salicylic acid and niacinamide make this cream a great fit by minimizing pores, smoothing texture, and helping control oil in your shiny areas. Glycerin and hyaluronic acid add essential hydration, while the gentle formula is safe and unlikely to cause irritation.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Panthenol do for combination skin?

Panthenol helps balance combination skin by boosting moisture while keeping redness and irritation calm. It is unlikely to cause breakouts and may help repair the skin barrier safely.
Sources: [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/), [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29577586/)

### What does Bha do for combination skin?

BHA helps clear breakouts and calms oily areas while keeping combination skin smooth, as it reduces blemishes and excess oil with a low risk of irritation. A product of this type needs soothing ingredients and gentle hydrators to balance combination skin.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/37941097/), [Experimental Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30972839/)

### Where does this cream go in a skincare routine for combination skin?

This cream goes in the evening routine as a treatment step after cleansing and before your moisturizer. It helps minimize pores and smooth texture safely without irritation.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying it after your retinol treatment to help soothe your skin and keep it hydrated. Using a moisturizing treatment alongside retinol is unlikely to cause irritation and helps support your skin barrier while you use active ingredients.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment in your evening routine, as treatments fit best at night for simplicity and extra safety around sun exposure. Once your skin adjusts well, you may carefully use it more often if you like.

### Can this cream clog pores, cause breakouts or purging for combination skin?

This cream is unlikely to clog pores or cause breakouts for combination skin, as it features salicylic acid and niacinamide to help clear pores and balance oil. It is well-suited to keep your skin smooth and calm without harsh ingredients.
Sources: [BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/)

### Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment on your body, but the skin around the eyes is much thinner and more delicate than facial and body skin, so use caution there. Because the formula lacks harsh ingredients, it is unlikely to cause irritation on normal areas, but test a small spot first if you apply it near the eyes.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/nl/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — €13.02 at Amazon
- [Anua Heartleaf 78% Soothing Cream](https://lovi.care/skincare/nl/p/anua/heartleaf-78-soothing-cream/for/combination-skin) — High fit — €25.29 at Amazon
- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/nl/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/combination-skin) — High fit — €104.95 at Amazon

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/nl/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €16.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/nl/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- SPF: [make p:rem UV Defense Me Blue Ray Sun Cream](https://lovi.care/skincare/nl/p/make-p-rem/uv-defense-me-blue-ray-sun-cream/for/combination-skin) — Superior fit — €33.70 at Amazon

## Where to buy

- Amazon.nl: €20.38 (https://www.amazon.nl/dp/B0BCK9G74Q?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Notino: €24.90 (https://www.notino.nl/medicube/zero-pore-one-day-cream-lichte-hydraterende-creme-voor-porie-minimalisatie/p-16299752/)
Prices checked 10 Oct – 5 Nov 2026.

## Ingredients

Water, Glycerin, Witch Hazel Extract, Panthenol, Allantoin, Melaleuca Alternifolia Tree Leaf Extract, Butylene Glycol, 12-Hexanediol, Hyaluronic Acid, Salicylic Acid, Niacinamide, Vitis Vinifera Fruit Extract Grape Fruit Extract, Camellia Sinensis Leaf Extract, Peptides, Sorbitan Olivate, Beta-Glucan
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-pore-one-day-cream/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-pore-one-day-cream/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-pore-one-day-cream/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-cream/for/combination-skin
- France: https://lovi.care/skincare/fr/p/medicube/zero-pore-one-day-cream/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-cream/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-cream/for/combination-skin (this page)
- Spain: https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-cream/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-pore-one-day-cream/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-pore-one-day-cream/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-cream/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-pore-one-day-cream/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-pore-one-day-cream/for/combination-skin