# Medicube PDRN Pink Collagen Gel Mask for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/nl/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Medicube](https://lovi.care/skincare/nl/brands/medicube)
Category: [Face masks](https://lovi.care/skincare/nl/best/face-masks)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other nourishing masks fit it better.

## Why this fit

- Suitable for normal skin, this mask offers excellent nourishing benefits due to sodium DNA and hydrolyzed collagen, which promote skin hydration and elasticity. Niacinamide further supports barrier repair and melanogenesis regulation, aligning well with your skin type.
- While it provides general skincare benefits, the concentrations of sodium DNA and hydrolyzed collagen are mostly supportive and not directly targeted for your primary concern of wrinkles and fine lines.
- The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/medicube/pdrn-pink-collagen-gel-mask/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/nl/p/medicube/pdrn-pink-collagen-gel-mask/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/nl/p/medicube/pdrn-pink-collagen-gel-mask/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/medicube/pdrn-pink-collagen-gel-mask/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/medicube/pdrn-pink-collagen-gel-mask/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/medicube/pdrn-pink-collagen-gel-mask/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/medicube/pdrn-pink-collagen-gel-mask/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/medicube/pdrn-pink-collagen-gel-mask/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Dna, Niacinamide, Hydrolyzed Collagen

## What the research says

- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- Polydeoxyribonucleotide treatment induces mitochondrial biogenesis while reducing melanin biosynthesis, tyrosinase activity, MITF expression, elastase activity, and MMP-1 gene expression in cultured skin cells. ([Applied Biochemistry and Biotechnology, 2020](https://pubmed.ncbi.nlm.nih.gov/31811642/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))

## Why other nourishing masks fit mature skin better

- Daily application of Galactomyces ferment filtrate-containing skin products for 12 months significantly and cumulatively reversed 11-year facial skin aging parameters of wrinkles, hyperpigmented spots, and roughness, and increased skin hydration in 86 female volunteers. ([Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/36769815/))
- Cordyceps sinensis mycelium hydroethanolic extract increased sirtuin expression, NAD+ synthesis, ATP production, collagen synthesis, and reduced ROS and wrinkles in in vitro assays and human subjects compared to controls. ([International Journal of Molecular Sciences, 2024](https://pubmed.ncbi.nlm.nih.gov/38673866/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))

## What reviewers say

Based on a very large amount of data, users with dry, dull, or aging skin frequently praise this mask for delivering a "glass skin" glow and deep hydration that plumps fine lines and revitalizes the complexion. The cooling effect and post-facial radiance are highly rated by many users. Some users find the application messy, the price point high, and the required wear time inconvenient.

- Liked: Hydration and glow (mostly mentioned)
- Liked: Soothing and cooling (often mentioned)
- Disliked: Expensive product (often mentioned)
- Disliked: Messy application (often mentioned)
- Liked: Good adherence (sometimes noted)
- Liked: Plumping effect (sometimes noted)
- Disliked: Poor fit (sometimes noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- You can use this sheet mask in your PM routine about 2-3 times a week. Smooth it gently over your face and relax.
- Apply the sheet mask right after cleansing and toning, but before putting on your moisturizer.
- Place the sheet mask flat on your face and smooth it out gently with your fingers. Leave it on for ten to fifteen minutes before removing.
- Put the sheet mask on clean and dry skin for the best comfort. Gently pat any remaining essence into your skin after taking it off.
- Avoid getting the product into your eyes and do a quick patch test before your very first use.
- Video: https://storage.pora.ai/cf9cbc1593b43309df7ca9cfe4fbbdae.mp4

## Questions and answers

### How well does medicube PDRN Pink Collagen Gel Mask work for mature skin?

This mask works for mature skin, though other products fit it better because its ingredients are mostly supportive rather than directly targeted for wrinkles and fine lines. To better help mature skin, a product of this type needs effective ingredients that directly address wrinkles and fine lines while providing rich hydration and nourishment.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### Which ingredients make this mask a good fit for mature skin?

Sodium DNA, niacinamide, and hydrolyzed collagen make this mask a good fit because they help keep mature skin hydrated and supported. While these ingredients provide general nourishment, a product for this skin needs higher concentrations targeted directly at reducing wrinkles and fine lines.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/), [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### What does Sodium DNA do for mature skin?

Sodium DNA helps smooth out fine lines, improve elasticity, and restore a firm feel for mature skin. Clinical reviews show it is effective at reducing wrinkles and improving overall skin texture with mild side effects.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39645667/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this mask go in a skincare routine for mature skin?

This mask goes in your weekly routine after the enzyme powder and before your treatment and moisturizer. It is very safe and unlikely to cause irritation, but a mature skin type needs targeted ingredients like potent peptides and retinoids to effectively smooth fine lines and wrinkles.
Sources: [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### Can I use this mask with retinol, and in what order?

You can use this mask along with retinol, applying the mask first in your weekly routine and following it with your treatment. This nourishing mask is very safe and unlikely to cause irritation for your skin. However, since its ingredients are mostly supportive rather than directly targeted for wrinkles and fine lines, mature skin also needs a targeted anti-aging treatment like retinol to address those concerns effectively.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this mask?

This nourishing mask fits into your weekly routine as a once-a-week step, since it is designed for weekly use rather than daily application. It is unlikely to cause irritation on normal skin, though mature skin often benefits more from targeted anti-aging treatments containing potent peptides or retinoids.

### Can this mask clog pores, cause breakouts or purging for mature skin?

This mask is unlikely to clog pores or cause breakouts for mature skin due to its gentle formulation without harsh ingredients. To better target wrinkles and fine lines, mature skin needs products with higher concentrations of active ingredients like retinoids or peptides that actively boost collagen production.

## Alternatives for mature skin

- [Allies of Skin 1A Retinal + Peptides Overnight Mask](https://lovi.care/skincare/nl/p/allies-of-skin/1a-retinal-and-peptides-overnight-mask/for/mature-skin) — High fit — €98.00 at Amazon
- [Saturday Skin Yuzu Vitamin C Sleep Mask](https://lovi.care/skincare/nl/p/saturday-skin/yuzu-vitamin-c-sleep-mask/for/mature-skin) — High fit — €87.92 at Amazon
- [Some By Mi Glow Luminous Ampoule Mask](https://lovi.care/skincare/nl/p/some-by-mi/glow-luminous-ampoule-mask/for/mature-skin) — High fit — €12.39 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/nl/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €48.84 at Amazon

## Where to buy

- Amazon.nl: €9.97 (https://www.amazon.nl/dp/B0DBF52CLJ?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €17.24 (https://www.lookfantastic.nl/p/medicube-pdrn-pink-collagen-gel-mask-4ea/17724798/)
- Notino: €19.50 (https://www.notino.nl/medicube/pdrn-pink-collagen-gel-mask-lifting-en-verstevigende-masker-met-collageen/p-16325844/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Sodium Dna, Niacinamide, Hydrolyzed Collagen
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/pdrn-pink-collagen-gel-mask/for/mature-skin