# Medicube EXOSOME CICA CALMING PAD for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Medicube](https://lovi.care/skincare/nl/brands/medicube)
Category: [Toners](https://lovi.care/skincare/nl/best/toners)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other toners fit it better.

## Why this fit

- Offers moderate soothing for your combination skin as Exosome Cica and Niacinamide work to reduce redness and calm inflammation, though they do not directly target acne concerns.
- Niacinamide aids in seboregulation, which is beneficial for combination skin, while Exosome Cica provides anti-inflammatory action.
- The product is safe for your acne-prone skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/mature-skin): Low
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/oily-acne-prone-skin): Average

## Key ingredients

Exosome Cica, Tree, Niacinamide

## What the research says

- Topical 5% tea tree oil gel significantly improved total acne lesions and acne severity index compared to placebo in 60 patients with mild to moderate acne vulgaris, showing 3.55 times and 5.75 times greater efficacy respectively. ([Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Tea tree oil nanoemulsion containing adapalene gel demonstrated significantly greater reductions in total, inflammatory, and non-inflammatory acne lesions as well as acne severity index compared to adapalene marketed gel in 100 patients with acne vulgaris over 12 weeks. ([Archives of Dermatological Research, 2022](https://pubmed.ncbi.nlm.nih.gov/34251536/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Dermocosmetic loaded with plant extract significantly improved skin texture and surface parameters including roughness, scaliness, smoothness, and wrinkles compared to a base without extract in Asian male volunteers over three months. ([Pakistan Journal of Pharmaceutical Sciences, 2020](https://pubmed.ncbi.nlm.nih.gov/32276894/))
- A cosmetic cream containing Harungana madagascariensis plant extract induces similar anti-aging effects to a retinol-containing cream on 46 human subjects, improving wrinkles, ptosis, color homogeneity, smoothness, plumpness, firmness, and elasticity. ([Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37155516/))
- An OTC topical formulation containing a plant extract complex improved skin extensibility and firmness significantly (P < 0.02) compared to placebo in 20 volunteers, with no adverse reactions. ([International Journal of Cosmetic Science, 2000](https://pubmed.ncbi.nlm.nih.gov/18503475/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))

## Why other toners fit acne-prone skin better

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))

## What reviewers say

Based on a very large amount of data, users with sensitive and acne-prone skin frequently praise these pads for their immediate cooling and redness-reducing effects, often noting significant relief from facial heat and irritation. While most find them highly hydrating and effective for smoothing skin texture, a minority of users felt they were less effective for active blemishes or found the pad material slightly rough.

- Liked: Rapid soothing cooling (mostly mentioned)
- Liked: Hydrating non-sticky (often mentioned)
- Liked: Generous essence (sometimes noted)
- Liked: Gentle exfoliation (sometimes noted)
- Liked: High adherence (sometimes noted)
- Disliked: High price point (rarely noted)
- Disliked: Ineffective on acne (rarely noted)
- Disliked: Pad texture rough (rarely noted)
- Disliked: Strong scent (rarely noted)

## How to apply

- Use your soothing toner AM and PM daily to help keep breakouts under control.
- Apply this soothing toner right after cleansing and before your moisturizer or SPF.
- Gently press 2-3 drops of the soothing toner into your skin and let it absorb.
- Pat the soothing toner onto clean, slightly damp skin for the best absorption.
- Always do a patch test before first use and avoid getting the soothing toner in your eyes.
- Video: https://storage.pora.ai/25abe7eb181ba53153fd15de2058c2a9.mp4

## Questions and answers

### How well does the medicube Exosome Cica Calming Pad work for acne-prone skin?

This product works moderately well for acne-prone skin, as it calms inflammation and reduces redness without directly targeting breakouts. A soothing toner for this skin needs ingredients that provide strong acne-fighting benefits and intensive blemish care while keeping the skin calm and hydrated.

### Which ingredients make this toner a good fit for acne-prone skin?

Exosome Cica, Tree, and Niacinamide make this toner a good fit by helping to calm redness and keep oil balanced on acne-prone skin. Because other products fit this skin better, a toner of this type needs ingredients that directly target breakouts along with soothing extracts and hydrating agents to manage both dry and oily areas effectively.
Sources: [Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/), [Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/)

### What do Exosomes do for acne-prone skin?

Exosomes help calm acne-prone skin by reducing inflammation and supporting healing from breakouts and marks. They are unlikely to cause major issues when used properly, though proper application method matters to avoid unwanted reactions.
Sources: [FASEB Journal, 2026](https://pubmed.ncbi.nlm.nih.gov/41474360/), [The Journal of Craniofacial Surgery, 2025](https://pubmed.ncbi.nlm.nih.gov/40257450/)

### What does Tea Tree Oil do for acne-prone skin?

Tea tree oil helps clear up blemishes and calms redness on acne-prone skin. It fights the bacteria that cause breakouts, making it a useful spot treatment for mild to moderate pimples with a low likelihood of irritation.
Sources: [Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/), [Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/)

### Where does this toner go in a skincare routine for acne-prone skin?

This soothing toner fits into your routine after cleansing and before moisturizing. To best care for acne-prone skin, a routine like this needs gentle exfoliating and targeted blemish-fighting ingredients.

### Can I use this toner with retinol, and in what order?

You can use this toner with retinol by applying it right after cleansing to calm your skin, and then following with your retinol treatment. This type of skin also needs targeted acne-fighting ingredients like salicylic acid or benzoyl peroxide to truly clear breakouts.

### How often should I use this toner?

You can use this soothing toner daily to help calm redness and inflammation, as it is safe for acne-prone skin with no risk of harsh irritation. However, because it only offers moderate soothing and does not directly target acne, this skin type also needs products with blemish-clearing ingredients like tea tree oil or acne-fighting actives to achieve the best results.
Sources: [Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/), [Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/)

### Can this toner clog pores, cause breakouts or purging for acne-prone skin?

This toner is safe for your acne-prone skin and is unlikely to clog pores or cause breakouts because it lacks harsh ingredients that trigger irritation. However, since it only offers moderate soothing and does not directly target acne, acne-prone skin typically needs products with ingredients like tea tree oil to actively clear blemishes and prevent breakouts.
Sources: [Indian Journal of Dermatology, Venereology and Leprology, 2007](https://pubmed.ncbi.nlm.nih.gov/17314442/), [Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/)

## Alternatives for acne-prone skin

- [Medicube Super Cica Pad](https://lovi.care/skincare/nl/p/medicube/super-cica-pad/for/acne-prone-skin) — Superior fit — €16.32 at Amazon
- [iUnik Tea Tree Relief Toner](https://lovi.care/skincare/nl/p/iunik/tea-tree-relief-toner/for/acne-prone-skin) — High fit — €19.89 at Amazon
- [Dr.G R.E.D Blemish Clear Soothing Toner](https://lovi.care/skincare/nl/p/dr-g/r-e-d-blemish-clear-soothing-toner/for/acne-prone-skin) — High fit — €36.90 at Amazon

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/nl/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €13.99 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/acne-prone-skin) — Superior fit — €19.20 at Amazon
- SPF: [d'Alba Piedmont Waterfull Mild Sunscreen](https://lovi.care/skincare/nl/p/d-alba/piedmont-waterfull-mild-sunscreen/for/acne-prone-skin) — Superior fit — €16.75 at Amazon

## Where to buy

- Amazon.nl: €46.96 (https://www.amazon.nl/dp/B0DFG4MRC9?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Notino: €26.50 (https://www.notino.nl/medicube/exosome-cica-calming-pad-toner-pads-met-kalmerend-effect/p-16359263/)
Prices checked 10 Oct – 4 Nov 2026.

## Ingredients

Exosome Cica, Tree, Niacinamide
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin (this page)
- Spain: https://lovi.care/skincare/es/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/exosome-cica-calming-pad/for/acne-prone-skin