# Medicube Deep Vita A Retinol Serum for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Medicube](https://lovi.care/skincare/nl/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate anti-aging benefits for your normal skin due to the presence of retinol and retinal, which help minimize fine lines and wrinkles.
- Centella Asiatica Extract and Dipotassium Glycyrrhizate provide supportive soothing effects for your redness and irritation.
- The product is safe for your normal skin with sensitivity, as it lacks prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/medicube/deep-vita-a-retinol-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/medicube/deep-vita-a-retinol-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/nl/p/medicube/deep-vita-a-retinol-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/nl/p/medicube/deep-vita-a-retinol-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/medicube/deep-vita-a-retinol-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/medicube/deep-vita-a-retinol-serum/for/mature-skin): Low
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/medicube/deep-vita-a-retinol-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/medicube/deep-vita-a-retinol-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Hydroxypinacolone Retinoate, Collagen Complex, Niacinamide, Squalane

## What the research says

- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- A topical serum containing hydroxypinacolone retinoate and peptides used twice daily for 16 weeks achieved parity or statistically significantly better improvement in facial aging parameters compared to a single fractional CO2 laser treatment in women with moderate global photodamage. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39394831/))
- Combined probiotic supplementation and topical azelaic acid with hydroxypinacolone retinoate reduced non-inflammatory lesions from 11.5 to 7.3 and decreased microscopic acne features measured by reflectance confocal microscopy and dynamic optical coherence tomography in 20 patients over 12 weeks. ([Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/37510902/))
- Hydroxypinacolone retinoate and retinyl propionate at a 5:9 weight ratio synergistically enhanced antiaging gene expressions in vitro and improved skin wrinkles, smoothness, transepidermal water loss, and elasticity in 42 Chinese urban women over an 8-week period without adverse reactions compared to retinol. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36762391/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Based on limited data, users find this serum to be an excellent beginner retinol, appreciated for its gentle and hydrating formula that minimizes irritation. It effectively smooths skin texture and refines pores, with many users reporting immediate brightening and a 'glass skin' effect. Deeper wrinkles are noted to improve with consistent, long-term use.

- Liked: Gentle, low irritation (mostly mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Hydrating, non-drying (sometimes noted)
- Liked: Pleasant texture (sometimes noted)
- Disliked: Slow wrinkle results (sometimes noted)
- Disliked: Mild purging (rarely noted)
- Disliked: Slightly sticky (rarely noted)
- Disliked: Small bottle size (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does medicube Deep Vita A Retinol work for sensitive skin?

This product works for sensitive skin, though other treatments fit it better. To work well for this skin type, a treatment needs soothing ingredients like Centella asiatica extract and niacinamide, along with gentle hydrators that calm redness and irritation without causing stinging.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Which ingredients make this serum a good fit for sensitive skin?

This serum fits sensitive skin moderately well thanks to Centella Asiatica Extract and Dipotassium Glycyrrhizate, which provide supportive soothing effects for redness and irritation. Retinol and retinal also help minimize fine lines and wrinkles. For this skin type, a product of this type needs soothing ingredients, potent antioxidants, hydrating components, and skin-repairing ingredients that calm redness while posing no risk of irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Retinol do for sensitive skin?

Retinol is generally too harsh for sensitive skin and may cause stinging, scaling, and irritation. A product for this skin needs gentle ingredients that smooth and calm without causing redness.
Sources: [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/), [Toxicology Letters, 2003](https://pubmed.ncbi.nlm.nih.gov/14615068/)

### What does Hydroxypinacolone Retinoate do for sensitive skin?

Hydroxypinacolone retinoate helps smooth lines and firm skin while keeping irritation low, making it a gentle choice for sensitive skin. Clinical studies show it improves wrinkles and elasticity without the redness often caused by traditional retinoids.
Sources: [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41450017/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36762391/)

### Where does this serum go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after your soothing toner and before your moisturizer. A product of this type needs gentle calming ingredients and soothing hydrators to keep sensitive skin comfortable.

### Can I use it with vitamin C, and in what order?

It is best to use vitamin C in your morning routine and this treatment at night to help prevent dryness and stinging on sensitive skin. To better fit sensitive skin, a treatment of this type needs calming ingredients and soothing agents like Centella Asiatica to keep the skin calm and comfortable.

### How often should I use this serum?

This serum works for sensitive skin in the evening, used in your routine after your toner and before your moisturizer. It helps smooth fine lines, but because sensitive skin needs extra care, a product of this type needs calming ingredients like centella asiatica and soothing plant extracts to keep the skin calm and comfortable.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36798538/), [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### Can it clog pores, cause breakouts or purging for sensitive skin?

This serum may cause mild purging for sensitive skin as it contains retinol and other vitamin A ingredients that speed up skin cell turnover. A product for this skin needs soothing and calming ingredients like Centella Asiatica extract and squalane to help keep irritation low.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum).

## Alternatives for sensitive skin

- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/nl/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €160.00 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/nl/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €35.50 at Amazon
- [COSRX The Vitamin C 23 Serum](https://lovi.care/skincare/nl/p/cosrx/the-vitamin-c-23-serum/for/sensitive-skin) — High fit — €19.00 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/nl/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/sensitive-skin) — Superior fit — €21.95 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/nl/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €17.96 at Amazon
- Moisturizer with Sun Protection: [Bioderma Bioderma Photoderm Mineral SPF 50+](https://lovi.care/skincare/nl/p/bioderma/photoderm-mineral-fluide-spf50/for/sensitive-skin) — Superior fit — €19.79 at Amazon

## Where to buy

- Amazon.nl: €28.75 (https://www.amazon.nl/dp/B0H7JHK95G?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €22.43 (https://www.lookfantastic.nl/p/medicube-deep-vita-a-retinol-serum-30ml/17902006/)
- Notino: €23.20 (https://www.notino.nl/medicube/deep-vita-a-retinol-serum-antirimpel-retinolserum-met-voedende-werking/p-16329862/)
Prices checked 10 Oct – 5 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Butylene Glycol, Glycerin, Propanediol, 1,2-Hexanediol, Niacinamide, Coco-Caprylate Caprate, Squalane, Polyglyceryl-3 Distearate, Dimethyl Isosorbide, Pentylene Glycol, Panthenol, 4-T-Butylcyclohexanol, Parfum, Hydrogenated Lecithin, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Sucrose Palmitate, Caprylic Capric Triglyceride, Hydroxypinacolone Retinoate, Diethylhexyl Syringylidenemalonate, Tromethamine, Ethylhexylglycerin, Glyceryl Stearate Citrate, Allantoin, Biosaccharide Gum-1, Dipotassium Glycyrrhizate, Xanthan Gum, Macadamia Ternifolia Seed Oil, Olea Europaea Oil Fruit Olive Oil Fruit, Jojoba Seed Oil, Vitis Vinifera Seed Oil Grape Seed Oil, Adenosine, Retinal, Sodium Hyaluronate, Disodium Edta, Retinol, Bakuchiol, Retinyl Palmitate, Brassica Campestris Sterols, Linoleic Acid, Cholesterol, Polyglyceryl-10 Laurate, Ceramide Np, Ppg-13-Decyltetradeceth-24, Retinyl Linoleate, Phytosteryl Behenyl Octyldodecyl Lauroyl Glutamate, Beta-Glucan, Aluminum Magnesium Hydroxide Stearate, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Potassium Cetyl Phosphate, Polyglyceryl-3 Methylglucose Distearate, Silica, Isopropyl Lauroyl Sarcosinate, Tocopherol, Hydrolyzed Collagen, Retinyl Retinoate, Chitosan, Centella Asiatica Extract, Centella Asiatica Leaf Extract, Centella Asiatica Root Extract, Tris Tetramethylhydroxypiperidinol Citrate, Benzotriazolyl Dodecyl P-Cresol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin
- France: https://lovi.care/skincare/fr/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin (this page)
- Spain: https://lovi.care/skincare/es/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/deep-vita-a-retinol-serum/for/sensitive-skin