# Medicube Deep Peptide Radiance Mask for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/nl/p/medicube/deep-peptide-radiance-mask/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Medicube](https://lovi.care/skincare/nl/brands/medicube)
Category: [Face masks](https://lovi.care/skincare/nl/best/face-masks)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best nourishing masks for combination skin.

## Why this fit

- Offers excellent nourishing benefits for your combination skin, as peptides like Acetyl Hexapeptide-1 and Palmitoyl Tripeptide-5 work to plump and improve elasticity, while niacinamide helps regulate sebum for oily shine.
- Hyaluronic acid and Centella Asiatica Leaf Extract further support hydration and soothing, making it a well-rounded choice for your skin type.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the inclusion of calming components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/medicube/deep-peptide-radiance-mask/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/medicube/deep-peptide-radiance-mask/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/medicube/deep-peptide-radiance-mask/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/nl/p/medicube/deep-peptide-radiance-mask/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/medicube/deep-peptide-radiance-mask/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/nl/p/medicube/deep-peptide-radiance-mask/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/medicube/deep-peptide-radiance-mask/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/medicube/deep-peptide-radiance-mask/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/medicube/deep-peptide-radiance-mask/for/oily-acne-prone-skin): Superior

## Key ingredients

Peptide Complex, Niacinamide, Centella Asiatica Leaf Extract, Hydrolyzed Hyaluronic Acid, Ceramide Np

## What the research says

- Supramolecular collagen nanoparticles composed of lactoferrin, recombinant human collagen, and palmitoyl tripeptide-5 improved transdermal efficiency by 69.90% and demonstrated moisturizing, whitening, wrinkle reduction, and firming effects. ([Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Treatment with an asiaticoside-containing cream applied twice daily for 12 weeks significantly improved periorbital wrinkles in 65% of 27 female volunteers compared to a vehicle control cream. ([International Journal of Cosmetic Science, 2008](https://pubmed.ncbi.nlm.nih.gov/18452433/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))

## What reviewers say

Based on limited data, users love this mask for its intense hydration and ability to provide an instant glow, making it ideal for dry, dull, or sensitive skin. The peptide-rich essence is praised for plumping fine lines and soothing irritation without a sticky feel. Some users find the price high for frequent use and note the sheet size can be slightly small.

- Liked: Intense hydration (mostly mentioned)
- Liked: Instant radiance (often mentioned)
- Liked: Non-sticky finish (sometimes noted)
- Liked: Soothing and plumping (sometimes noted)
- Disliked: High price point (sometimes noted)
- Disliked: Handling difficulty (rarely noted)
- Disliked: Sheet fit issues (rarely noted)

## How to apply

- You can use this sheet mask PM or AM to control oily shine. Start 3 times a week and increase if your skin likes it.
- Apply this sheet mask after cleansing and toning, and before putting on your moisturizer.
- Unfold the sheet mask and gently press it onto your face, smoothing it out without rubbing. Leave it on for ten to fifteen minutes before removing.
- Put the sheet mask on clean skin to help your face absorb the essence better. Pat any remaining liquid gently into your skin.
- Avoid getting the product too close to your eyes. Do a quick patch test before your very first use.
- Video: https://storage.pora.ai/cf9cbc1593b43309df7ca9cfe4fbbdae.mp4

## Questions and answers

### What makes the Deep Peptide Radiance Mask a great fit for combination skin?

This mask is a great fit because peptides like Acetyl Hexapeptide-1 and Palmitoyl Tripeptide-5 help plump and improve elasticity, while niacinamide regulates oily shine. Hyaluronic acid and Centella Asiatica Leaf Extract further support hydration and keep skin calm and soft.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/)

### Which ingredients make this mask a good fit for combination skin?

This mask is a great fit for your combination skin because peptides like acetyl hexapeptide-1 and palmitoyl tripeptide-5 help plump and improve elasticity, while niacinamide regulates oily shine. Hyaluronic acid and centella asiatica leaf extract further support hydration and calm the skin without any irritation.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/)

### What does Peptide Complex do for combination skin?

Peptide Complex helps hydrate combination skin, improve elasticity, and smooth the look of lines with daily use. It is unlikely to cause irritation and may also help firm the skin over time.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30834689/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37335808/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this mask go in a skincare routine for combination skin?

This nourishing mask is a great fit for your combination skin because it helps plump and improve elasticity while managing oily shine. It is unlikely to cause irritation and works well to keep your skin hydrated and calm.
Sources: [Colloids and Surfaces. B, Biointerfaces, 2025](https://pubmed.ncbi.nlm.nih.gov/39383579/)

### Can I use this mask with retinol, and in what order?

You can use this mask alongside retinol, applying the mask after your retinol treatment to help soothe and hydrate your skin. This combination is unlikely to cause irritation because the mask contains calming ingredients that support your skin barrier.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this mask?

This mask is a great fit for your combination skin and can be used regularly to keep your face plump and smooth. It offers nourishing benefits and helps manage oily shine while providing comforting hydration.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this mask clog pores, cause breakouts or purging for combination skin?

This mask is unlikely to clog pores, cause breakouts, or lead to purging on combination skin. It features soothing ingredients like Centella Asiatica Leaf Extract and niacinamide, which helps regulate oil, along with a very safe makeup that avoids harsh irritants.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### Is this mask fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Behenyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Anua Heartleaf 77% Soothing Sheet Mask](https://lovi.care/skincare/nl/p/anua/heartleaf-77-soothing-sheet-mask/for/combination-skin) — High fit — €24.00 at Amazon
- [Pyunkang Yul Ceramide Calming Mask Pack](https://lovi.care/skincare/nl/p/pyunkang-yul/ceramide-calming-mask-pack/for/combination-skin) — High fit — €25.99 at Amazon
- [Dr. Jart+ Ceramidin Facial Barrier Mask](https://lovi.care/skincare/nl/p/dr-jart/ceramidin-facial-barrier-mask/for/combination-skin) — High fit — €33.35 at Lookfantastic

## Pairs well with

- Cleanser: [Dr. Althea Amino Acid Gentle Bubble Cleanser](https://lovi.care/skincare/nl/p/dr-althea/amino-acid-gentle-bubble-cleanser/for/combination-skin) — Superior fit — €16.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/nl/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/combination-skin) — Superior fit — €19.20 at Amazon

## Where to buy

- Amazon.nl: €5.99 (https://www.amazon.nl/dp/B0HGBQSTDY?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Notino: €5.20 (https://www.notino.nl/medicube/deep-peptide-radiance-mask-hydraterende-sheet-mask-voor-verhoging-van-de-huidelasticiteit/p-16364197/)
Prices checked 16 Oct – 4 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, Butylene Glycol, Niacinamide, 1,2-Hexanediol, Cetyl Ethylhexanoate, Panthenol, Allantoin, Xylitol, Centella Asiatica Leaf Extract, Lactobacillus Lysate Ferment, Lactococcus Lysate Ferment, Bifida Lysate Ferment, Caprylyl Glycol, Sorbitan Laurate, Hydrogenated Lecithin, Hydrolyzed Hyaluronic Acid, Tocopherol, Asiaticoside, Madecassic Acid, Asiatic Acid, Acetyl Dipeptide-1, Cetyl Ester, Acetyl Hexapeptide-1, Palmitoyl Tripeptide-5, Beta-Glucan, Ceramide Np, Acetyl Octapeptide-3, Hydrogenated Oil, Behenyl Alcohol, Polyglyceryl-3 Methylglucose Distearate, Arginine, Carbomer, Adenosine, Hydroxyethylcellulose, Ethylhexylglycerin, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/deep-peptide-radiance-mask/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/deep-peptide-radiance-mask/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/deep-peptide-radiance-mask/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/medicube/deep-peptide-radiance-mask/for/combination-skin
- France: https://lovi.care/skincare/fr/p/medicube/deep-peptide-radiance-mask/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/medicube/deep-peptide-radiance-mask/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/deep-peptide-radiance-mask/for/combination-skin (this page)
- Spain: https://lovi.care/skincare/es/p/medicube/deep-peptide-radiance-mask/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/deep-peptide-radiance-mask/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/medicube/deep-peptide-radiance-mask/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/deep-peptide-radiance-mask/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/deep-peptide-radiance-mask/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/deep-peptide-radiance-mask/for/combination-skin