# Medicube Collagen Jelly Cream for mature skin

**Lovi Fit: Superior fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/nl/p/medicube/collagen-jelly-cream/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Medicube](https://lovi.care/skincare/nl/brands/medicube)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/nl/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for mature skin.

## Why this fit

- Excellent for your normal skin, this formula leverages collagen and hydrolyzed collagen to effectively hydrate and improve skin elasticity, addressing your concerns about wrinkles and fine lines. Niacinamide and trehalose further support your skin by providing humectant action and barrier repair, enhancing overall skin health.
- The inclusion of adenosine and glycerin contributes to reducing the appearance of wrinkles and maintaining skin hydration, complementing the primary ingredients.
- This product is safe for your skin, as it contains soothing ingredients like glycerin and tocopherol and lacks harsh or prohibited substances.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/medicube/collagen-jelly-cream/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/medicube/collagen-jelly-cream/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/medicube/collagen-jelly-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/medicube/collagen-jelly-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/medicube/collagen-jelly-cream/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/nl/p/medicube/collagen-jelly-cream/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/nl/p/medicube/collagen-jelly-cream/for/mature-skin): Superior (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/medicube/collagen-jelly-cream/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/medicube/collagen-jelly-cream/for/oily-acne-prone-skin): High

## Key ingredients

Collagen, Niacinamide, Hydrolyzed Collagen, Trehalose, Squalane

## What the research says

- Sodium trehalose sulfate decreased transepidermal water loss and increased stratum corneum water content in participants with low stratum corneum water content when applied for 4 weeks compared to placebo. ([Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38606717/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects. ([International Journal of Cosmetic Science, 2018](https://pubmed.ncbi.nlm.nih.gov/29574973/))
- Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30160014/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical chloramphenicol-betamethasone combined with sodium hyaluronate/trehalose/carbomer gel compared to chloramphenicol-betamethasone alone reduced most subjective symptoms at 1 week but increased blurred vision at 4 weeks following strabismus surgery in 31 patients, with no significant differences in conjunctival inflammation between treatments. ([Journal of Ocular Pharmacology and Therapeutics, 2019](https://pubmed.ncbi.nlm.nih.gov/31298607/))
- Topical treatment with Thealoz Duo significantly improved dry eye disease symptoms, tear break-up time, and restored tear lipid layer functionality by reducing inflammatory response proteins in moderate to severe dry eye patients over 56 days. ([Journal of Clinical Medicine, 2025](https://pubmed.ncbi.nlm.nih.gov/40807147/))
- An injectable product combining different molecular weights of hyaluronic acid and trehalose reduced CML formation by 45% at baseline and 30% under methylglyoxal-induced stress while preserving cell viability in human skin explants compared to untreated controls. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/40244036/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Based on a very large amount of data, this moisturizer is highly regarded for providing an immediate radiant glow and deep hydration, resulting in a plump and dewy complexion. Its unique jelly texture is a point of division; while many appreciate its cooling and bouncy feel, a notable number of users, particularly those with oily or sensitive skin, find it unpleasantly sticky and slow to absorb.

- Liked: Glass skin glow (mostly mentioned)
- Liked: Hydration and plumping (often mentioned)
- Disliked: Stickiness and tackiness (often mentioned)
- Liked: Cooling jelly texture (sometimes noted)
- Liked: Device compatibility (sometimes noted)
- Disliked: Slow absorption (sometimes noted)
- Disliked: Strong fragrance (sometimes noted)
- Disliked: Breakouts or congestion (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Medicube Collagen Jelly Cream one of the best fits for mature skin?

Medicube Collagen Jelly Cream is an exceptional fit for mature skin because it utilizes collagen and hydrolyzed collagen to hydrate and improve skin elasticity, which helps address wrinkles and fine lines. Niacinamide and trehalose further support this by providing barrier repair and helping to keep the skin plump and healthy. Glycerin and tocopherol add soothing hydration while ensuring the formula remains gentle and safe for daily use.
Sources: [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38606717/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a good fit for mature skin?

This cream is a great fit for mature skin because it uses collagen and hydrolyzed collagen to hydrate and improve skin elasticity, while niacinamide, trehalose, adenosine, and glycerin help smooth out wrinkles and keep the skin feeling soft. These ingredients work together safely to improve firmness and maintain daily moisture without harsh additives.
Sources: [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38606717/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Collagen do for mature skin?

Collagen helps smooth mature skin by reducing wrinkles, improving hydration, and keeping the skin firm and plump. It is a weak fit for your skin, so a product of this type needs added hyaluronic acid, antioxidants, and peptides to properly nourish and support aging skin.
Sources: [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/), [Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing out fine lines and wrinkles, reducing dark spots, and improving overall skin elasticity. It is also very well tolerated and supports a strong skin barrier to keep skin looking healthy.
Sources: [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this cream go in a skincare routine for mature skin?

This moisturizing treatment goes in your morning routine after a hydrating toner and before SPF, and in your evening routine as your final step after a treatment. It helps hydrate and improve skin elasticity to address wrinkles and fine lines using collagen, niacinamide, and trehalose.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/), [International Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/31461548/)

### Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying the cream first to help your skin tolerate the retinol better. Using a moisturizer with barrier-supporting ingredients is unlikely to cause irritation and may help reduce the dryness often linked to retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment twice daily to help keep mature skin hydrated and smooth. Regular daily application supports skin elasticity and helps reduce the look of fine lines and wrinkles over time.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for mature skin?

This moisturizing treatment is unlikely to clog pores or cause breakouts for mature skin, as it has a low risk for causing congestion. Its gentle formula helps keep skin soft without heavy oils that typically trigger breakouts.

### Can I use this cream around the eyes or on my body?

This cream is suitable for mature skin on the face, but its formula and heavy texture are not specifically tailored for the very thin skin around the eyes or general body use. For those areas, mature skin typically benefits from lightweight, specialized treatments with targeted moisturizers and barrier-repairing ingredients.

### Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (parfum).

## Alternatives for mature skin

- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/nl/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — €69.99 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/nl/p/the-ordinary/natural-moisturizing-factors-ha/for/mature-skin) — High fit — €13.02 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Cream](https://lovi.care/skincare/nl/p/missha/super-aqua-ultra-hyalron-cream/for/mature-skin) — High fit — €39.42 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- SPF: [SKIN1004 MADAGASCAR CENTELLA AIR-FIT SUNCREAM PLUS](https://lovi.care/skincare/nl/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/mature-skin) — Superior fit — €14.70 at Amazon

## Where to buy

- Amazon.nl: €19.21 (https://www.amazon.nl/dp/B0CM2PPNMW?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Notino: €15.50 (https://www.notino.nl/medicube/collagen-jelly-cream-intensief-gelcreme-met-collageen/p-16301264/)
- Lookfantastic: €21.74 (https://www.lookfantastic.nl/p/medicube-collagen-jelly-cream-110ml/16858534/)
Prices checked 10 Oct – 5 Nov 2026.

## Ingredients

Water, Propanediol, Dipropylene Glycol, Butylene Glycol, Methylpropanediol, Diethoxyethyl Succinate, Ethoxydiglycol, Ammonium Acryloyldimethyltaurate Beheneth-25 Methacrylate Crosspolymer, Niacinamide, Trehalose, 1,2-Hexanediol, Chlorella Vulgaris Extract, Collagen, Hydrolyzed Collagen, Cynanchum Atratum Extract, Althaea Rosea Flower Extract, Water-Soluble Collagen, Allium Sativum Bulb Extract, Avena Sativa Kernel Extract Oat Kernel Extract, Bertholletia Excelsa Seed Extract, Brassica Oleracea Italica Extract, Camellia Sinensis Seed Extract, Salmon Egg Extract, Solanum Lycopersicum Fruit Extract Tomato Fruit Extract, Spinach Leaf Extract, Blueberry Fruit Extract, Wine Extract, Polyglyceryl-10 Isostearate, Tromethamine, Glucose, Polyglyceryl-10 Oleate, Ethylhexylglycerin, Fructooligosaccharides, Fructose, Adenosine, Sodium Phytate, Cyanocobalamin, Tocopherol, Pullulan, Glycerin, Hydroxypropyltrimonium Hyaluronate, Squalane, Soluble Proteoglycan, Hydrolyzed Elastin, Sodium Dna, Carbomer, Xanthan Gum, Parfum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/collagen-jelly-cream/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/collagen-jelly-cream/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/collagen-jelly-cream/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medicube/collagen-jelly-cream/for/mature-skin
- France: https://lovi.care/skincare/fr/p/medicube/collagen-jelly-cream/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medicube/collagen-jelly-cream/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/collagen-jelly-cream/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/medicube/collagen-jelly-cream/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/collagen-jelly-cream/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medicube/collagen-jelly-cream/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/collagen-jelly-cream/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/collagen-jelly-cream/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/collagen-jelly-cream/for/mature-skin