# Medi-Peel Bor-Tox Peptide Ampoule for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/nl/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Medi-Peel](https://lovi.care/skincare/nl/brands/medi-peel)
Category: [Serums and treatments](https://lovi.care/skincare/nl/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for skin with dark spots.

## Why this fit

- Offers excellent wrinkle reduction for your normal skin due to peptides like copper tripeptide-1 and acetyl hexapeptide-8, which help plump and improve elasticity.
- The inclusion of hydrolyzed collagen and sodium hyaluronate provides beneficial hydration and supports collagen stimulation, aligning well with your normal skin type.
- The product is safe for your skin, as it contains no harsh or irritating ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/medi-peel/bor-tox-peptide-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/nl/p/medi-peel/bor-tox-peptide-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/nl/p/medi-peel/bor-tox-peptide-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/nl/p/medi-peel/bor-tox-peptide-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/medi-peel/bor-tox-peptide-ampoule/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/nl/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/nl/p/medi-peel/bor-tox-peptide-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/medi-peel/bor-tox-peptide-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/medi-peel/bor-tox-peptide-ampoule/for/oily-acne-prone-skin): High

## Key ingredients

5 Peptide Complex, Hydrolyzed Collagen, Sodium Hyaluronate, Copper Tripeptide-1, Fermentation Complex

## What the research says

- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- A peptide complex stimulated basement membrane protein expressions and significantly improved skin wrinkles at all five measured sites after two weeks in 22 healthy Asian female volunteers older than 40 years. ([International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31861912/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- A combination serum containing galactomyces ferment filtrate, dexpanthenol, and Centella asiatica effectively treated post-acne hyperpigmentation in subjects with colored skin by significantly increasing lightness scores in Fitzpatrick skin type V and reducing the melanin index in Fitzpatrick skin type IV compared to placebo. ([Skinmed, 2021](https://pubmed.ncbi.nlm.nih.gov/33938432/))
- Application of Galactomyces ferment filtrate skin care formula significantly reduced the net values and daily fluctuation of facial pore area, roughness, and redness in young Japanese women. ([Journal of Clinical Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34198790/))
- Galactomyces ferment filtrate promotes epidermal interconnectivity, barrier development, cell adhesion, keratinocyte differentiation and proliferation, and protects cellular bioenergetics against stress in keratinocytes and ex vivo skin explants compared to untreated controls. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38924095/))

## What reviewers say

Based on a very large amount of data, this ampoule is widely praised for its ability to deeply hydrate and plump the skin, resulting in a bouncy, youthful glow that softens fine lines. Many users appreciate its milky, non-sticky texture and suitability for sensitive skin. Some users find the anti-aging claims exaggerated and struggle with the inefficient dropper packaging.

- Liked: Deep hydration & plumping (mostly mentioned)
- Liked: Elegant texture (often mentioned)
- Liked: Smoother skin texture (often mentioned)
- Disliked: Poor dropper design (often mentioned)
- Liked: Gentle on sensitive skin (sometimes noted)
- Disliked: Divisive scent (sometimes noted)
- Disliked: Lack of dramatic anti-aging (sometimes noted)
- Disliked: Small quantity/value (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medi-Peel Bor-Tox Peptide Ampoule a great fit for skin with dark spots?

Medi-Peel Bor-Tox Peptide Ampoule is a great fit because it helps plump and improve elasticity for smooth skin using peptides like copper tripeptide-1 and acetyl hexapeptide-8. It also provides beneficial hydration with hydrolyzed collagen and sodium hyaluronate while maintaining a safe profile without harsh or irritating ingredients.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Which ingredients make this serum a good fit for skin with dark spots?

Sodium hyaluronate and hydrolyzed collagen make this serum a good fit by providing beneficial hydration to help keep skin smooth. Additionally, peptides like copper tripeptide-1 and acetyl hexapeptide-8 help plump and improve elasticity for a more youthful look.
Sources: [International Journal of Molecular Sciences, 2019](https://pubmed.ncbi.nlm.nih.gov/31861912/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Peptide Complex do for skin with dark spots?

Peptide complex helps improve skin tone and smooths out dark spots on the face. Formulas with peptides and antioxidants are unlikely to cause irritation while brightening the skin.
Sources: [Dermatology and Therapy, 2025](https://pubmed.ncbi.nlm.nih.gov/39720967/), [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39761149/)

### What does Hydrolyzed Collagen do for skin with dark spots?

Hydrolyzed collagen helps improve overall skin health and texture, but for dark spots, a product of this type needs added brightening ingredients like vitamin C or niacinamide to help fade discoloration.
Sources: [Cureus, 2023](https://pubmed.ncbi.nlm.nih.gov/38192916/), [International Journal of Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33742704/)

### Where does this serum go in a skincare routine for skin with dark spots?

This treatment goes in the evening routine after cleansing and toning, and before moisturizing. Putting it at night keeps it simple and safe around sun exposure, though some serums can also be used in the morning or twice a day.

### Can I use this serum with retinol, and in what order?

Yes, you can use this serum with retinol by applying the serum first to keep your skin hydrated and smooth, followed by your retinol. This approach is unlikely to irritate your skin since the formula contains gentle, soothing ingredients.

### How often should I use this serum?

This serum fits well into your evening routine as a treatment step, used as often as your skin tolerates it safely. Peptides like acetyl hexapeptide-8 help smooth and soften the skin with a very safe profile.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to clog pores or cause breakouts for skin with dark spots because it contains no harsh or irritating ingredients. It has a safe profile that works gently to help keep skin smooth and clear.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for skin with dark spots

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/nl/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dark-spots) — High fit — €10.20 at Amazon
- [Clinique Fresh Pressed Daily Booster with Pure Vitamin C 10%](https://lovi.care/skincare/nl/p/clinique/fresh-pressed-daily-booster-with-pure-vitamin-c-10/for/dark-spots) — High fit — €99.41 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/nl/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — €203.88 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/nl/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €21.00 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/nl/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €14.31 at Amazon
- Moisturizer: [SKIN1004 Centella Cream](https://lovi.care/skincare/nl/p/skin1004/centella-cream/for/dark-spots) — Superior fit — €19.20 at Amazon

## Where to buy

- Amazon.nl: €18.95 (https://www.amazon.nl/dp/B08M14P5TK?tag=lovi-care-web-product085-21&linkCode=osi&th=1&psc=1)
- Notino: €23.50 (https://www.notino.nl/medi-peel/peptide-tox-serum-met-peptiden/p-16306395/)
Prices checked 10 Oct – 5 Nov 2026.

## Ingredients

Hydrolyzed Collagen, Water, Butylene Glycol, Hydrogenated Polyisobutene, 1,2-Hexanediol, Polyacrylamide, Lactobacillus Pumpkin Extract Ferment, Lactobacillus Soybean Extract Ferment, C13-14 Isoparaffin, Polysorbate 20, Arginine, Lactobacillus Punica Granatum Extract Fruit Ferment, Lactobacillus Wasabia Japonica Extract Root Ferment, Sodium Hyaluronate, Ethylhexylglycerin, Saccharomyces Grape Extract Ferment, Carbomer, Allantoin, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Saccharomyces Ferment Filtrate, Laureth-7, Bifida Lysate Ferment, Disodium Edta, Adenosine, Leontopodium Alpinum Callus Culture Extract, Hydrolyzed Elastin, Gardenia Florida Fruit Extract, Anemarrhena Asphodeloides Root Extract, Inonotus Obliquus Extract Mushroom Extract, Palm Oil, Copper Tripeptide-1, Acetyl Hexapeptide-8, Oligopeptide-32, Oligopeptide-29, Palmitoyl Pentapeptide-4
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots
- France: https://lovi.care/skincare/fr/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots (this page)
- Spain: https://lovi.care/skincare/es/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/medi-peel/bor-tox-peptide-ampoule/for/dark-spots