# Le Mieux Bio Cell Rejuvenating Cream for dry skin

**Lovi Fit: High fit for dry skin.**
Dry Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/nl/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [Le Mieux](https://lovi.care/skincare/nl/brands/le-mieux)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/nl/best/moisturizers)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for dry skin.

## Why this fit

- Highly suitable for your dry skin as sodium hyaluronate and squalane offer excellent humectant and emollient actions, respectively, to hydrate and enhance barrier resilience.
- The inclusion of ceramides further supports barrier function, addressing dryness and flakiness effectively.
- The product is safe for your dry skin, containing no harsh ingredients and featuring soothing components like shea butter.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/le-mieux/bio-cell-rejuvenating-cream/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin): High (this page)
- [Combination skin](https://lovi.care/skincare/nl/p/le-mieux/bio-cell-rejuvenating-cream/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/le-mieux/bio-cell-rejuvenating-cream/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/nl/p/le-mieux/bio-cell-rejuvenating-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/le-mieux/bio-cell-rejuvenating-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/le-mieux/bio-cell-rejuvenating-cream/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/le-mieux/bio-cell-rejuvenating-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Squalane, Argan Oil, Acetyl Hexapeptide-8, Ceramide Np

## What the research says

- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Emulsions containing ceramides 1 and 3 improved skin hydration and reduced transepidermal water loss in sodium lauryl sulfate-irritated skin of fifteen healthy Asian women compared to a control emulsion. ([International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/))
- A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin. ([Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events. ([Lasers in Medical Science, 2025](https://pubmed.ncbi.nlm.nih.gov/41134387/))
- Topical application of an argan oil NLC-based hydrogel formulation increased skin hydration in healthy volunteers over a one-month period through a synergistic effect of NLC occlusion and argan oil hydration. ([International Journal of Nanomedicine, 2014](https://pubmed.ncbi.nlm.nih.gov/25143733/))
- Incorporating allantoin into argan oil enriched liposomes improved its accumulation in the dermis (~8.7μg/cm(2)) and permeation through the skin (~33μg/cm(2)) compared to conventional liposomes, water dispersion, and a commercial gel. ([International Journal of Pharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27063848/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))

## What reviewers say

This moisturizer is widely celebrated for its rich, non-greasy formula that effectively targets dehydration, loss of firmness, and fine lines. It is particularly favored by users with dry or mature skin types who seek a product that leaves the complexion feeling soft, supple, and visibly rejuvenated.

- Liked: Deep hydration (mostly mentioned)
- Liked: Radiant finish (often mentioned)
- Liked: Silky texture (often mentioned)
- Liked: Improves lines (sometimes noted)
- Disliked: Irritation risk (rarely noted)
- Disliked: Price point (rarely noted)
- Disliked: Too rich (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using it 3 times a week and work your way up to daily use.
- Apply your moisturizer after your toner and before your sunscreen in the morning. At night, use it as the final step after your serum.
- Gently press a small amount of the moisturizer into your skin. Avoid rubbing to keep your dry skin happy.
- Apply the moisturizer on slightly damp skin to help lock in extra hydration. This is great for soothing dry and flaky areas .
- Avoid the sensitive eye area and do a patch test before your first use .
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Le Mieux Bio Cell Rejuvenating Cream a great fit for dry skin?

This cream is a great fit for dry skin because sodium hyaluronate and squalane hydrate and keep your skin soft and smooth, while ceramides and shea butter help calm dryness and flakiness. It has a very safe profile with no harsh ingredients.
Sources: [International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/)

### Which ingredients make this cream a good fit for dry skin?

Sodium hyaluronate and squalane help hydrate your skin and strengthen its outer layer. Additionally, ceramides and shea butter work to soothe dryness and flakiness while supporting overall skin barrier function.
Sources: [International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/)

### What does Hyaluronic Acid do for dry skin?

Hyaluronic acid draws moisture into dry skin, giving an immediate and lasting boost in hydration that helps smooth out fine lines and soften rough patches. It is very gentle and unlikely to cause irritation while improving overall skin smoothness and plumpness.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### What does Squalane do for dry skin?

Squalane helps keep dry skin soft and smooth by acting as a hydrating agent that locks in moisture and prevents water loss. It is unlikely to cause irritation and may protect the skin from damage while improving overall hydration.
Sources: [Advances in Food and Nutrition Research, 2012](https://pubmed.ncbi.nlm.nih.gov/22361190/), [Molecules, 2009](https://pubmed.ncbi.nlm.nih.gov/19169201/)

### Where does this cream go in a skincare routine for dry skin?

This moisturizing treatment goes after your cleanser, hydrating toner, and before your SPF in the morning, or as your final moisturizing step in the evening routine. Consistently using a dedicated moisturizer helps improve visual dryness and overall skin comfort.
Sources: [The Journal of Dermatological Treatment, 2022](https://pubmed.ncbi.nlm.nih.gov/32239984/)

### Can I use this cream with retinol, and in what order?

You can use this cream with retinol by applying the cream after your retinol to help calm irritation and keep your dry skin soft. Using a barrier-supporting moisturizer alongside retinol helps reduce dryness and flakiness while supporting your skin barrier.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment twice a day as part of your morning and evening routine to keep your skin hydrated. Regular daily application helps improve skin moisture and softness while protecting against dryness and flakiness.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this cream clog pores, cause breakouts or purging for dry skin?

This cream is unlikely to clog pores or cause breakouts on dry skin because it features soothing components like shea butter and has a negligible risk of irritation. Reviewers rarely mention the product being too rich, supporting its suitability for your skin type.

### Can I use this cream around the eyes or on my body?

This cream works well for dry skin around the eyes and on the body because sodium hyaluronate and squalane hydrate the skin while ceramides protect against dryness and flakiness. Regular use in these areas is unlikely to cause irritation and helps improve skin texture.
Sources: [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/), [International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for dry skin

- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/nl/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/dry-skin) — High fit — €104.95 at Amazon
- [Medi-Peel Peptide 9 Volume Tox Cream](https://lovi.care/skincare/nl/p/medi-peel/peptide-9-volume-tox-cream/for/dry-skin) — High fit — €24.95 at Amazon
- [StriVectin SD Advanced Plus Intensive Moisturizing Concentrate](https://lovi.care/skincare/nl/p/strivectin/sd-advanced-plus-intensive-moisturizing-concentrate/for/dry-skin) — High fit — €76.63 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/nl/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — €21.95 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/nl/p/dear-klairs/supple-preparation-unscented-toner/for/dry-skin) — Superior fit — €16.89 at Amazon
- SPF: [Purito Daily Soft Touch Sunscreen](https://lovi.care/skincare/nl/p/purito/daily-soft-touch-sunscreen/for/dry-skin) — Superior fit — €20.01 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Sodium Hyaluronate, Acetyl Hexapeptide-8, Dipalmitoyl Hydroxyproline, Palmitoyl Pentapeptide-4, Palmitoyl Tripeptide-5, Ceramide Eop, Ceramide Np, Squalane, Cimicifuga Racemosa Root Extract Black Cohosh Root Extract, Saccharomyces Lysate Extract, Glyceryl Polymethacrylate, Jojoba Seed Oil, Argania Spinosa Oil Argan Oil, Plukenetia Volubilis Seed Oil, Butyrospermum Parkii Butter Shea Butter, Cetyl Alcohol, Tocotrienols Vitamin E, Tocopheryl Linoleate, Sodium Carboxymethyl Beta-Glucan, Vitis Vinifera Seed Extract Grape Seed Extract, Oenothera Biennis Oil, Rosa Canina Oil Rosehip Oil, Proprietary Blend Essential Oil, Caprylyl Glycol, Ethylhexylglycerin, Undecylenoyl Glycine, Capryloyl Glycine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin
- France: https://lovi.care/skincare/fr/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin (this page)
- Spain: https://lovi.care/skincare/es/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/le-mieux/bio-cell-rejuvenating-cream/for/dry-skin