# La Mer Genaissance de la Mer The Infused Lotion for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/nl/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for the Netherlands.

Brand: [La Mer](https://lovi.care/skincare/nl/brands/la-mer)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/nl/best/moisturizers)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few moisturizers fit it even better.

## Why this fit

- Offers excellent moisturizing treatment for your normal skin, as glycerin and sodium hyaluronate provide effective hydration and plumping. Squalane further supports your skin's natural moisture barrier, enhancing overall suppleness.
- The inclusion of acetyl hexapeptide-8 and tetrahexyldecyl ascorbate addresses your concerns about wrinkles and fine lines by supporting anti-aging benefits.
- This formula is safe for your normal skin, featuring soothing ingredients like Laminaria Digitata Extract and Blueberry Fruit Extract with no harsh components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/nl/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/nl/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/nl/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/nl/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/nl/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/nl/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/nl/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/nl/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/nl/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/oily-acne-prone-skin): Average

## Key ingredients

Squalane, Niacin, Sodium Hyaluronate, Algae Extract, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Bog blueberry anthocyanin-rich extract attenuated ultraviolet-B-induced toxicity, DNA damage, collagen degradation, and inflammatory cytokine release in human dermal fibroblasts by modulating NF-kappaB and MAPK signaling pathways. ([Molecular Nutrition & Food Research, 2009](https://pubmed.ncbi.nlm.nih.gov/19199288/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Treatment with lipid algae extract reduced the level of oxidized proteins in human keratinocytes and stratum corneum skin cells. ([Annals of the New York Academy of Sciences, 2004](https://pubmed.ncbi.nlm.nih.gov/15247018/))
- Topical astaxanthin-loaded algae extract hydrogel and lipogel formulations exhibited the highest antioxidant activity and successful in vitro release, suggesting their potential as anti-aging formulations. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29745467/))
- Antarctic marine algae extracts increased cell viability, protected against inflammation, and enhanced the barrier integrity of human intestinal and keratinocyte cell lines damaged by lipopolysaccharide or ultraviolet radiation. ([Marine Drugs, 2022](https://pubmed.ncbi.nlm.nih.gov/36135751/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

Based on limited data, users frequently highlight this lotion's luxurious, velvety texture that provides deep hydration and leaves skin feeling plump and soft. Many also appreciate its soothing properties and ability to impart a healthy radiance. However, a significant number of users find the extremely high price point to be a major drawback, and a smaller group has experienced breakouts or felt the results did not justify the cost.

- Liked: Deep hydration (mostly mentioned)
- Liked: Luxurious texture (often mentioned)
- Disliked: Exorbitant price (often mentioned)
- Liked: Radiance and glow (sometimes noted)
- Liked: Soothing and calming (sometimes noted)
- Disliked: Bottle design issues (sometimes noted)
- Disliked: Diminishing returns (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help smooth fine lines.
- Apply this product after your toner and serum, but before your SPF in the morning. Follow your cleanser and toner steps to keep your skin balanced.
- Gently press a small amount into your face and neck. Avoid rubbing the skin too harshly to prevent extra tension.
- Apply the moisturizer on slightly damp skin to help lock in extra moisture. Clean skin helps the product absorb much more evenly.
- Avoid the sensitive eye area during application. Do a quick patch test before your very first use to stay safe.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes La Mer The Infused Lotion a great fit for mature skin?

This moisturizing treatment is a great fit for mature skin because glycerin and sodium hyaluronate provide effective hydration, while squalane supports your moisture barrier to help keep skin soft and smooth. Additionally, acetyl hexapeptide-8 and vitamin c address wrinkles and fine lines for helpful anti-aging benefits.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Which ingredients make this treatment a good fit for mature skin?

This treatment is a great fit for mature skin because ingredients like acetyl hexapeptide-8 and tetrahexyldecyl ascorbate help smooth fine lines and wrinkles. Additionally, sodium hyaluronate, glycerin, and squalane provide deep hydration and help keep the skin plump and soft.
Sources: [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/), [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/)

### What does Squalane do for mature skin?

Squalane helps keep mature skin feeling soft and smooth by boosting moisture and protecting the skin barrier. It also provides antioxidant support that helps improve the look of fine lines and wrinkles over time.
Sources: [Journal of Nanobiotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40001122/), [Journal of Nanoscience and Nanotechnology, 2010](https://pubmed.ncbi.nlm.nih.gov/21137794/)

### What does Niacinamide do for mature skin?

Niacinamide helps mature skin by smoothing fine lines and wrinkles while improving elasticity and overall surface structure. It also supports skin barrier strength and can reduce the appearance of dark spots and red blotches.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/)

### Where does this treatment go in a skincare routine for mature skin?

This moisturizing treatment is used in the evening as part of your routine for mature skin. Applying treatments at night helps keep things simple and offers extra safety around sun exposure.

### Can I use this treatment with retinol, and in what order?

Yes, you can use this treatment alongside retinol to help keep your skin soft and smooth while reducing dryness and irritation. Apply your retinol product first, let it absorb, and then follow with this moisturizing treatment to support your skin barrier.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this treatment?

This moisturizing treatment is a great fit for your mature skin and is safe to use daily. Applying it twice a day helps improve hydration, fine lines, and overall skin smoothness.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26151786/)

### Can this treatment clog pores, cause breakouts or purging for mature skin?

This moisturizing treatment is unlikely to clog pores or cause breakouts for mature skin. It features a safe formula with soothing ingredients and no harsh components that could disrupt your skin.

### Can I use this treatment around the eyes or on my body?

This moisturizing treatment is well-suited for mature skin, but you should check with your dermatologist before applying it to the very thin skin around your eyes or on large areas of your body. Because the skin in these areas can react differently, products used there generally need extra-gentle, highly compatible hydration and soothing ingredients to avoid irritation.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this treatment fragrance-free and alcohol-free?

It contains fragrance (parfum, linalool, citronellol, geraniol, and limonene) and drying alcohol (alcohol denat).

## Alternatives for mature skin

- [L'Occitane Immortelle Divine Cream](https://lovi.care/skincare/nl/p/l-occitane/immortelle-divine-cream/for/mature-skin) — Superior fit — €69.99 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/nl/p/the-ordinary/natural-moisturizing-factors-ha/for/mature-skin) — High fit — €13.02 at Amazon
- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/nl/p/revision-skincare/hydrating-serum/for/mature-skin) — High fit — €252.17 at Amazon

## Pairs well with

- Cleanser: [d'Alba White Truffle Return Oil Cream Cleanser](https://lovi.care/skincare/nl/p/d-alba/white-truffle-return-oil-cream-cleanser/for/mature-skin) — Superior fit — €25.07 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/nl/p/some-by-mi/snail-truecica-miracle-repair-toner/for/mature-skin) — Superior fit — €19.90 at Amazon
- SPF: [SKIN1004 MADAGASCAR CENTELLA AIR-FIT SUNCREAM PLUS](https://lovi.care/skincare/nl/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/mature-skin) — Superior fit — €14.70 at Amazon

## Where to buy

No store in Netherlands has a checked price for this product, so the page shows none.

## Ingredients

Water, Dimethicone, Methyl Trimethicone, Isododecane, Phenyl Trimethicone, Polysilicone-11, Squalane, Glycerin, Glycereth-26, Propanediol, Algae Extract, Sesamum Indicum Seed Oil, Medicago Sativa Seed Powder, Helianthus Annuus Seedcake Sunflower Seedcake, Prunus Amygdalus Dulcis Seed Meal Seed, Eucalyptus Globulus Oil Leaf Eucalyptus Oil Leaf, Sodium Gluconate, Copper Gluconate, Calcium Gluconate, Magnesium Gluconate, Zinc Gluconate, Tocopheryl Succinate, Niacin, Sesamum Indicum Seed Powder, Sapindus Mukorossi Fruit Extract, Linoleic Acid, Garcinia Mangostana Peel Extract, Citrus Aurantifolia Peel Extract, Helichrysum Italicum Extract, Laminaria Digitata Extract, Cranberry Fruit Extract, Blueberry Fruit Extract, Lycium Chinense Fruit Extract Wolfberry Fruit Extract, Whey Lactis Proteine Du Petit-Lait Protein, Jania Rubens Extract, Yeast Faex Extrait De Levure Extract, Citrus Reticulata Peel Extract Tangerine Peel Extract, Cladosiphon Okamuranus Extract, Sucrose, Bis-Stearyl Dimethicone, Cetyl Dimethicone, Persea Gratissima Oil Avocado Oil, Caffeine, Chondrus Crispus, Lactobacillus Ferment, Yeast Polysaccharides, Sodium Hyaluronate, Trehalose, Acetyl Hexapeptide-8, Caprylic Capric Triglyceride, Isononyl Isononanoate, Acetyl Glucosamine, Triolein, Phytosteryl Canola Glycerides, Hydrolyzed Wheat Protein, Caesalpinia Spinosa Gum, Tourmaline, Peg-40 Hydrogenated Castor Oil, Gold, Peg-75, Butylene Glycol, Ethylhexyl Isononanoate, Caprylyl Glycol, Saccharide Isomerate, Peg-7m, Dextrin, Tocopheryl Acetate, Tetrahexyldecyl Ascorbate, Citric Acid, Sodium Hydroxide, Maltodextrin, Hexylene Glycol, Oleic Acid, Palmitic Acid, Stearic Acid, Polymethylsilsesquioxane, Alcohol Denat, Vinyl Dimethicone Methicone Silsesquioxane Crosspolymer, Parfum, Trimethylsiloxysilicate, Disodium Edta, Bht, Sodium Benzoate, Chlorphenesin, Phenoxyethanol, Linalool, Citronellol, Geraniol, Hydroxycitronellal, Limonene, Red 4 Ci 14700
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin
- France: https://lovi.care/skincare/fr/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin (this page)
- Spain: https://lovi.care/skincare/es/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/la-mer/genaissance-de-la-mer-the-infused-lotion/for/mature-skin